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Biodegradable hydrophilic polymer microsphere for face injection filling and preparation method thereof

A hydrophilic polymer and biodegradable technology, which is applied in the field of biodegradable hydrophilic polymer microspheres for facial injection filling and its preparation, can solve the problem of poor adhesion and adhesion of facial tissues and the impact of polyethylene lactide The use of microspheres is prone to problems such as aggregation and delamination to achieve good water absorption, low ash content, and easy preparation

Active Publication Date: 2022-04-22
苏州踏青医疗科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] The applicant found in practical application that when the polylactide microspheres are used for facial filling, they cannot fit and adhere well in the facial tissue , easy to agglomerate and disperse, and at the same time, when polylactide microspheres are mixed with hyaluronic acid aqueous solution, coagulation and delamination are also easy to occur, which affects the use of polylactide microspheres

Method used

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  • Biodegradable hydrophilic polymer microsphere for face injection filling and preparation method thereof
  • Biodegradable hydrophilic polymer microsphere for face injection filling and preparation method thereof
  • Biodegradable hydrophilic polymer microsphere for face injection filling and preparation method thereof

Examples

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Embodiment 1

[0049] A biodegradable hydrophilic polymer microsphere for facial injection filling, its electron micrograph is shown in figure 1 , figure 2 Shown, its raw material ratio is shown in Table 1.

[0050] Among them, the degradable polymer film-forming polymer is polylactic acid, and is selected from 4032D of NatureWorks in the United States; the hydrophilic phospholipid is lecithin, and the lecithin is soybean lecithin, and is selected from Shenzhen Haisheng Biotechnology Co., Ltd.; The solvent is chloroform; the inverse emulsification water solvent is polyvinyl alcohol aqueous solution, and the mass concentration of the polyvinyl alcohol aqueous solution is 3%, and the polyvinyl alcohol is selected from CP2020 of Shanxi Jinyang Pharmaceutical Excipients Co., Ltd.

[0051] A preparation method of biodegradable hydrophilic polymer microspheres for facial injection filling, comprising the steps of:

[0052] S1. Under the condition of a stirring speed of 500 r / min, add a degradab...

Embodiment 2-8

[0055] A biodegradable hydrophilic polymer microsphere for facial injection filling, the difference between it and Example 1 is that the raw material ratio of the hydrophilic polymer microsphere is different, and the rest are the same as Example 1, and Example 1 The raw material ratio of 2-8 hydrophilic polymer microspheres is shown in Table 1.

Embodiment 9

[0057] A biodegradable hydrophilic polymer microsphere for facial injection filling, the difference between it and Example 2 is that the degradable polymer film-forming polymer in the hydrophilic polymer microsphere is different, and the remaining parts are the same as in Example 2 The same, and the degradable polymer film-forming polymer is polycaprolactone, and is selected from PCL-05 of Shenzhen Boli Biomaterials Co., Ltd.

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Abstract

The invention relates to the technical field of processing of polymer microspheres for face injection and filling, and particularly discloses biodegradable hydrophilic polymer microspheres for face injection and filling and a preparation method of the biodegradable hydrophilic polymer microspheres. The solute of the oil phase mixture is mainly prepared from the following raw materials: a degradable polymer film-forming polymer and hydrophilic phospholipid, and the hydrophilic phospholipid is one or more of lecithin, cephalin, phosphatidylserine, phosphatidylglycerol, cardiolipin and phosphatidylinositol. The hydrophilic polymer microspheres not only have good hydrophilicity and facial tissue compatibility, but also can be stably dispersed in a hyaluronic acid aqueous solution, meanwhile, the raw materials of the polymer microspheres are simple and easy to obtain, the polymer microspheres have the advantages of being easy and convenient to prepare and convenient to process and control, and the safety of the hydrophilic polymer microspheres is also improved.

Description

technical field [0001] This application relates to the technical field of processing polymer microspheres for facial injection filling, more specifically, it relates to a biodegradable hydrophilic polymer microsphere for facial injection filling and a preparation method. Background technique [0002] With the development of society and the advancement of science and technology, people pay more and more attention to the quality of life and the pursuit of beauty, and the cosmetic surgery industry in my country has also entered a stage of rapid development. It is becoming more and more widely accepted to correct soft tissue defects and repair aging and wrinkled skin through plastic surgery technology to maintain the perfect facial shape. Among them, injection beauty technology occupies an important place. Injection beauty technology is to partially modify the human body through injection. It has the advantages of zero repair and quick results, making it the first choice for bea...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/18A61L27/20A61L27/16A61L27/50A61L27/54A61L27/58
CPCA61L27/18A61L27/20A61L27/16A61L27/50A61L27/54A61L27/58A61L2400/06A61L2300/622A61L2300/112C08L67/04C08L5/04C08L5/08C08L29/04
Inventor 杨杨刘振涛杨新广
Owner 苏州踏青医疗科技有限公司
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