Multifunctional photo-thermal diagnosis and treatment agent based on 2DTi3C2MXene nanosheet as well as preparation method and application of multifunctional photo-thermal diagnosis and treatment agent
A nano-sheet, multifunctional technology, applied in the field of medicine, can solve the problems of deep tissue imaging, high background interference, small penetration depth, etc., and achieve the effects of low side effects, significant tumor growth, and good application prospects
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Embodiment 1
[0036] Embodiment 1: obtain Ti 3 C 2 Preparation of nanosheets
[0037] (1) Mix 20 mL of 9M HCl with 1 g of LiF and stir slowly at 40 °C for 15 minutes until the LiF is completely dissolved. 1 g Ti 3 AlC 2 The crystals were slowly added to the mixture of HCl and LiF, stirred at 45 °C for 25 hours, and then washed alternately with deionized water and ethanol until the pH of the supernatant obtained by centrifugation was ≈ 6, then centrifuged at 4500 rpm for 10 minutes, and collected to obtain is precipitated, resulting in layered Ti 3 C 2 , with a size between 3 and 5 μm.
[0038] (2) the layered Ti obtained in step (1) 3 C 2 The wet precipitate was dissolved in 40 ml of absolute ethanol, and ultrasonically treated in a 200W water bath for 90 minutes to make Ti 3 C 2 The aggregates were preliminarily delaminated, and the final product was dissolved in deionized water after repeated washing with deionized water and absolute ethanol. The resulting solution was sonicate...
Embodiment 2
[0039] Example 2: NaErF 4 :0.5% Tm@NaLuF 4 Preparation of Rare Earth Fluorescent Nanoparticles
[0040] (1) Add 6 mL of oleic acid and 15 mL of octadecene into a three-necked flask, and add 0.382 g of ErCl 3 with 0.00191 g TmCl 3 Add it to dissolve; under the protection of argon, deoxygenate for 30 minutes, then gradually increase the temperature to 160 ° C and stir for 30 minutes to ErCl 3 Dissolve completely, and after the solution is completely clear, cool the system to room temperature; add 5 mL containing 0.1 g NaOH and 0.148 g NH 4 F in methanol solution, gradually heated to 70°C and maintained for 25 minutes to remove the methanol solution; then heated to 300°C under argon protection, and then maintained for 90 minutes to obtain Tm 3+ NaErF with a molar doping concentration of 0.5% 4 : 0.5% Tm nanoparticle luminous nucleus solution;
[0041] (2) NaErF obtained in step (1) 4 After the 0.5% Tm nanoparticle luminescent core solution is cooled to room temperature, it i...
Embodiment 3
[0044] Embodiment 3: Based on 2D Ti 3 C 2 Preparation of multifunctional photothermal diagnostic agent of MXene nanosheets
[0045] (1) Surface modification of oily nanoparticles with poor water solubility, 4mL 0.1M HCl, 2mL cyclohexane and 2mLNaErF 4 :0.5% Tm@NaLuF 4 The nanoparticle cyclohexane solution was mixed and stirred vigorously for 9 hours. The obtained solution showed obvious layering phenomenon, the lower aqueous phase solution was mixed with 2mL acetone solution, centrifuged at 10,000rmp for 15 minutes, the obtained wet precipitate was dissolved in 2mL deionized water, and finally the surface-modified NaErF 4 :0.5% Tm@NaLuF 4 Aqueous solution of nanoparticles.
[0046] (2) Add 500 μL of surface-modified NaErF 4 :0.5% Tm@NaLuF 4 Nanoparticle aqueous solution, 30mg polyacrylic acid (PAA) and 4.5mL deionized water were mixed, and ultrasonically treated in a water bath for 20 minutes to fully compound the system. After several times of centrifugation to remove...
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