Multifunctional photo-thermal diagnosis and treatment agent based on 2DTi3C2MXene nanosheet as well as preparation method and application of multifunctional photo-thermal diagnosis and treatment agent

A nano-sheet, multifunctional technology, applied in the field of medicine, can solve the problems of deep tissue imaging, high background interference, small penetration depth, etc., and achieve the effects of low side effects, significant tumor growth, and good application prospects

Pending Publication Date: 2022-05-06
JILIN UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the commonly used fluorescence imaging method is imaging in the near-infrared region, and its emission wavelength is maintained between 750 and 900nm, which coincides with the tissue autofluorescence emission region in the organism, resulting in high background interference, high scattering, and penetration depth. Small size, inability to perform deep tissue imaging, etc.

Method used

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  • Multifunctional photo-thermal diagnosis and treatment agent based on 2DTi3C2MXene nanosheet as well as preparation method and application of multifunctional photo-thermal diagnosis and treatment agent
  • Multifunctional photo-thermal diagnosis and treatment agent based on 2DTi3C2MXene nanosheet as well as preparation method and application of multifunctional photo-thermal diagnosis and treatment agent
  • Multifunctional photo-thermal diagnosis and treatment agent based on 2DTi3C2MXene nanosheet as well as preparation method and application of multifunctional photo-thermal diagnosis and treatment agent

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] Embodiment 1: obtain Ti 3 C 2 Preparation of nanosheets

[0037] (1) Mix 20 mL of 9M HCl with 1 g of LiF and stir slowly at 40 °C for 15 minutes until the LiF is completely dissolved. 1 g Ti 3 AlC 2 The crystals were slowly added to the mixture of HCl and LiF, stirred at 45 °C for 25 hours, and then washed alternately with deionized water and ethanol until the pH of the supernatant obtained by centrifugation was ≈ 6, then centrifuged at 4500 rpm for 10 minutes, and collected to obtain is precipitated, resulting in layered Ti 3 C 2 , with a size between 3 and 5 μm.

[0038] (2) the layered Ti obtained in step (1) 3 C 2 The wet precipitate was dissolved in 40 ml of absolute ethanol, and ultrasonically treated in a 200W water bath for 90 minutes to make Ti 3 C 2 The aggregates were preliminarily delaminated, and the final product was dissolved in deionized water after repeated washing with deionized water and absolute ethanol. The resulting solution was sonicate...

Embodiment 2

[0039] Example 2: NaErF 4 :0.5% Tm@NaLuF 4 Preparation of Rare Earth Fluorescent Nanoparticles

[0040] (1) Add 6 mL of oleic acid and 15 mL of octadecene into a three-necked flask, and add 0.382 g of ErCl 3 with 0.00191 g TmCl 3 Add it to dissolve; under the protection of argon, deoxygenate for 30 minutes, then gradually increase the temperature to 160 ° C and stir for 30 minutes to ErCl 3 Dissolve completely, and after the solution is completely clear, cool the system to room temperature; add 5 mL containing 0.1 g NaOH and 0.148 g NH 4 F in methanol solution, gradually heated to 70°C and maintained for 25 minutes to remove the methanol solution; then heated to 300°C under argon protection, and then maintained for 90 minutes to obtain Tm 3+ NaErF with a molar doping concentration of 0.5% 4 : 0.5% Tm nanoparticle luminous nucleus solution;

[0041] (2) NaErF obtained in step (1) 4 After the 0.5% Tm nanoparticle luminescent core solution is cooled to room temperature, it i...

Embodiment 3

[0044] Embodiment 3: Based on 2D Ti 3 C 2 Preparation of multifunctional photothermal diagnostic agent of MXene nanosheets

[0045] (1) Surface modification of oily nanoparticles with poor water solubility, 4mL 0.1M HCl, 2mL cyclohexane and 2mLNaErF 4 :0.5% Tm@NaLuF 4 The nanoparticle cyclohexane solution was mixed and stirred vigorously for 9 hours. The obtained solution showed obvious layering phenomenon, the lower aqueous phase solution was mixed with 2mL acetone solution, centrifuged at 10,000rmp for 15 minutes, the obtained wet precipitate was dissolved in 2mL deionized water, and finally the surface-modified NaErF 4 :0.5% Tm@NaLuF 4 Aqueous solution of nanoparticles.

[0046] (2) Add 500 μL of surface-modified NaErF 4 :0.5% Tm@NaLuF 4 Nanoparticle aqueous solution, 30mg polyacrylic acid (PAA) and 4.5mL deionized water were mixed, and ultrasonically treated in a water bath for 20 minutes to fully compound the system. After several times of centrifugation to remove...

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Abstract

The invention discloses preparation of a multifunctional photo-thermal diagnosis and treatment agent based on a 2D Ti3C2MXene nanosheet and application of the multifunctional photo-thermal diagnosis and treatment agent to preparation of a photo-thermal medicine for tumor treatment, and belongs to the technical field of medicine. The multifunctional photo-thermal diagnosis and treatment agent is a Ti3C2 nanosheet loaded with NaErF4: 0.5% Tm and NaLuF4 nano particles of a core-shell structure, and the surface of the photosensitizer Ti3C2 nanosheet is modified with the NaErF4: 0.5% Tm and NaLuF4 nano particles subjected to surface modification to obtain the multifunctional photo-thermal diagnosis and treatment agent. The multifunctional photo-thermal diagnosis and treatment agent has high photo-thermal conversion efficiency (eta = 43.62%) and good photo-thermal stability and biocompatibility, and growth inhibition and ablation of tumors can be effectively completed; meanwhile, efficient MR / NIR-IIb multi-mode imaging can be guided, the treatment process can be guided and monitored, and a diagnosis and treatment agent can be better applied to clinical medicine treatment.

Description

technical field [0001] The invention belongs to the technical field of medicine, in particular to a two-dimensional (2D) Ti 3 C 2 A multifunctional photothermal diagnostic and therapeutic agent of MXene nanosheets, a preparation method and a photothermal drug for preparing tumor treatment. Background technique [0002] Cancer (malignant tumor) is currently one of the most important diseases that threaten human survival and health. At the same time, the incidence and mortality of cancer worldwide are also increasing rapidly. Although the world has invested a lot of energy in the field of cancer treatment in recent years , but the results achieved are still insufficient to effectively curb the growing burden of cancer. Traditional tumor treatment methods are mainly divided into surgery, radiotherapy and chemotherapy. Although the tumor can be removed by surgery, it cannot effectively prevent cancer recurrence caused by the spread of cancer cells and is accompanied by posto...

Claims

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Application Information

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IPC IPC(8): A61K41/00A61K49/00A61K49/08A61K49/18A61K49/12A61P35/00
CPCA61K41/0052A61K41/0057A61K49/0004A61K49/0013A61K49/08A61K49/18A61K49/126A61P35/00A61K2300/00
Inventor 潘嘉林卢革宇刘晓敏
Owner JILIN UNIV
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