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Preparation method of licorice crude extract

A technology of crude extract and licorice, which is applied in the field of preparation of crude extract of licorice, can solve the problems of not being able to adapt to the development trend of active ingredient extraction technology, unstable properties, low extraction rate, etc., and achieve shortening of pretreatment and extraction time, structure And the effect of stable properties and high extraction efficiency

Pending Publication Date: 2022-05-13
漯河汇德生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, these extraction methods in the prior art have defects such as low extraction rate, low purity, high cost, and unstable properties during the extraction process, and cannot adapt to the development trend of modern active ingredient extraction technology.

Method used

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  • Preparation method of licorice crude extract
  • Preparation method of licorice crude extract

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] A preparation method of astragalus crude extract, comprising the following steps:

[0035] (1) Dry and clean licorice roots are pulverized with low-temperature liquid nitrogen; licorice powder is obtained after passing through a 150-mesh sieve; wherein the nitrogen feed rate is 2mL / s during the low-temperature liquid nitrogen pulverization process, and the licorice feed rate is 3g / s; pulverize The temperature is -5°C;

[0036] (2) Put 1 part of astragalus powder, 4 parts of water, 0.1 part of polysorbate, 0.04 part of cellulase, 0.02 part of pectinase, 0.02 part of protease, and 0.02 part of α-amylase at 55 ° C and a pH value of 5.0 Enzymolysis treatment under conditions for 1h;

[0037] (3) Inactivate the enzymatic solution at 90°C for 10 minutes; then extract at 90°C for 75 minutes; filter; concentrate the enzymatic solution under reduced pressure and low temperature to 1 / 4 of the original volume to obtain a concentrated solution;

[0038] (4) Adsorb the concentrate...

Embodiment 2

[0040] A preparation method of astragalus crude extract, comprising the following steps:

[0041] (1) The dry and clean licorice root is pulverized with low-temperature liquid nitrogen; licorice powder is obtained after passing through a 100-mesh sieve; wherein the feed rate of nitrogen during the pulverization process with low-temperature liquid nitrogen is 1mL / s, and the feed rate of licorice is 2g / s; The temperature is -10°C;

[0042] (2) 1 part of astragalus powder, 4 parts of water, 0.1 part of polyoxyethylene fatty acid ester active agent, 0.04 part of cellulase, 0.02 part of pectinase, 0.01 part of protease, 0.01 part of α-amylase at 50 ℃, Enzymolysis treatment for 0.5h under the condition of pH value 4.0;

[0043] (3) Inactivate the enzymatic solution at 80°C for 5 minutes; then extract at 80°C for 60 minutes; filter; concentrate the enzymatic solution under reduced pressure and low temperature to 1 / 3 of the original volume to obtain a concentrated solution;

[0044]...

Embodiment 3

[0046] A preparation method of astragalus crude extract, comprising the following steps:

[0047] (1) Dry and clean licorice roots are pulverized with low-temperature liquid nitrogen; licorice powder is obtained after passing through a 200-mesh sieve; wherein the nitrogen feed rate is 3mL / s during the low-temperature liquid nitrogen pulverization process, and the licorice feed rate is 4g / s; pulverize The temperature is 0°C;

[0048] (2) Put 1 part of astragalus powder, 4 parts of water, 0.1 part of polyoxyethylene fatty alcohol ether active agent, 0.04 part of cellulase, 0.02 part of pectinase, 0.01 part of protease, and 0.02 part of α-amylase at 60 ° C 1. Enzymolysis treatment for 1.5 hours under the condition of pH value 6.0;

[0049] (3) Inactivate the enzymatic solution at 100°C for 15 minutes; then extract at 100°C for 90 minutes; filter; concentrate the enzymatic solution under reduced pressure and low temperature to 1 / 5 of the original volume to obtain a concentrated s...

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Abstract

The invention discloses a preparation method of a licorice crude extract, which belongs to the field of traditional Chinese medicine extraction, and comprises the following steps: crushing licorice with low temperature liquid nitrogen, and sieving to obtain licorice powder; adding water into the licorice powder, uniformly stirring and soaking, and adding a biological enzyme and a nonionic active agent for enzymolysis; carrying out enzyme deactivation, extraction, filtration and concentration on the enzymatic hydrolysate to obtain a concentrated solution; and eluting the concentrated solution, collecting the eluent, and drying to obtain the licorice crude extract. The preparation method is simple, the extraction efficiency is high, the crude licorice extract is high in purity and yield, extraction of active substances and efficient separation of medicinal active components and impurity components are truly achieved, and the activity of the crude licorice extract can be reserved to the maximum extent.

Description

technical field [0001] The invention relates to the field of traditional Chinese medicine extraction, in particular to a preparation method of crude licorice extract. Background technique [0002] Licorice, one of the commonly used Chinese herbal medicines, has the effect of adrenal cortex hormone, anti-inflammatory, anti-ulcer, anti-allergic, anti-cancer, anti-bacterial, anti-virus, promotes pancreatic juice secretion, inhibits isolated intestine, regulates immune function, and antitussive Eliminates phlegm, anti-mutation, detoxification, anti-oxidation, protects ear vestibular function, diuretic, protects liver, prevents arteriosclerosis, resists cerebral ischemia, prevents complications of diabetes, etc. [0003] Licorice extract is a medicinal ingredient extracted from licorice. Licorice extract generally contains: glycyrrhizin, glycyrrhizic acid, glycyrrhizin, licorice flavonoids, bistanol, formononetin, quercetin, etc. It is yellow to brown yellow powder. It has the...

Claims

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Application Information

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IPC IPC(8): A61K36/484
CPCA61K36/484A61K2236/19A61K2236/331A61K2236/55A61K2236/53A61K2236/51
Inventor 李玉龙安彩霞于忠良胡华良韩艳杰付媛媛栗双华李红娟高远高宇
Owner 漯河汇德生物科技有限公司
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