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Two-dimensional MXene-inorganic-organic hybrid multifunctional hydrogel for promoting wound healing of infectious diabetes mellitus and preparation method of two-dimensional MXene-inorganic-organic hybrid multifunctional hydrogel

A technology of wound healing and organic hybridization, which is applied in the fields of pharmaceutical formulations, bandages, drug delivery, etc., can solve the problems of not being able to effectively improve the wound microenvironment, poor self-healing ability, and poor anti-infection ability, and achieve the purpose of inhibiting the growth of planktonic bacteria , Strong tissue adhesion, good anti-oxidation effect

Pending Publication Date: 2022-05-27
NORTHWESTERN POLYTECHNICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] However, there are still problems in the prior art that hydrogels used for wound repair in infectious diabetes have weak tissue adhesion, poor self-healing ability, poor anti-infection ability, and inability to effectively improve the microenvironment of the wound.

Method used

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  • Two-dimensional MXene-inorganic-organic hybrid multifunctional hydrogel for promoting wound healing of infectious diabetes mellitus and preparation method of two-dimensional MXene-inorganic-organic hybrid multifunctional hydrogel
  • Two-dimensional MXene-inorganic-organic hybrid multifunctional hydrogel for promoting wound healing of infectious diabetes mellitus and preparation method of two-dimensional MXene-inorganic-organic hybrid multifunctional hydrogel
  • Two-dimensional MXene-inorganic-organic hybrid multifunctional hydrogel for promoting wound healing of infectious diabetes mellitus and preparation method of two-dimensional MXene-inorganic-organic hybrid multifunctional hydrogel

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0047] (1) Pluronic F127-methanesulfonate (F127-SO 3 ) preparation: 12.6g of F127 was dissolved in 120mL of anhydrous dichloromethane, then 0.88mL of triethylamine and 0.32mL of methanesulfonyl chloride were added successively, and the mixture was stirred at room temperature for 24h. After the reaction was complete, it was extracted with dichloromethane and the organic phase was washed with 1M hydrochloric acid and saturated sodium chloride. After drying with anhydrous sodium sulfate, it is precipitated in cold ether and dried in vacuo to obtain F127-SO 3 (89% yield).

[0048] (2) Preparation of F127-p-hydroxybenzaldehyde (FCHO): 12.17g F127-SO 3 Dissolve in 120mL DMF, then add 0.52g p-hydroxybenzaldehyde and 0.59g potassium carbonate (K 2 CO 3 ), reacted at 80°C for 72h. After the reaction was completed, it was cooled to room temperature, 150 mL of water was added and extracted with dichloromethane. Then the organic phase was washed with saturated sodium chloride, dried...

Embodiment 2

[0056] (1) P123-methanesulfonate (P123-SO 3 ) preparation: 5.8g of P123 was dissolved in 70mL of anhydrous dichloromethane, then 0.56mL of triethylamine and 0.76g of methanesulfonyl chloride were sequentially added to react at room temperature for 24h. After the reaction was completed, it was extracted with dichloromethane and the organic phase was washed with dilute hydrochloric acid and saturated sodium chloride. After drying with anhydrous sodium sulfate, it is precipitated in cold ether and dried in vacuo to obtain P123-SO 3 (88% yield).

[0057] (2) Preparation of P123-p-hydroxybenzaldehyde (PCHO): 2.5g P123-SO 3 Dissolve in 40mL DMF, then add 0.15g p-hydroxybenzaldehyde and 0.16g potassium carbonate (K 2 CO 3 ) and reacted at 80°C for 72h. After the reaction was completed, it was cooled to room temperature, 50 mL of water was added and extracted with dichloromethane. Then, the organic phase was washed with saturated sodium chloride, dried over anhydrous magnesium s...

Embodiment 3

[0065] (1) Pluronic F127-methanesulfonate (F127-SO 3 ) preparation: 12.6g of F127 was dissolved in 120mL of anhydrous dichloromethane, then 0.88mL of triethylamine and 0.32mL of methanesulfonyl chloride were added successively, and the mixture was stirred at room temperature for 24h. After the reaction was complete, it was extracted with dichloromethane and the organic phase was washed with 1M hydrochloric acid and saturated sodium chloride. After drying with anhydrous sodium sulfate, it is precipitated in cold ether and dried in vacuo to obtain F127-SO 3 (87% yield).

[0066] (2) Preparation of F127-p-hydroxybenzaldehyde (FCHO): 12.17g F127-SO 3 Dissolve in 120mL DMF, then add 0.52g p-hydroxybenzaldehyde and 0.59g potassium carbonate (K 2 CO 3 ), reacted at 80°C for 72h. After the reaction was completed, it was cooled to room temperature, 150 mL of water was added and extracted with dichloromethane. Then, the organic phase was washed with saturated sodium chloride, drie...

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Abstract

The invention relates to a two-dimensional MXene-inorganic-organic hybrid multifunctional hydrogel for promoting wound healing of infectious diabetes mellitus and a preparation method thereof, the two-dimensional MXene-inorganic-organic hybrid multifunctional hydrogel is a polyether-p-hydroxybenzaldehyde aqueous solution, a branched cationic polymer aqueous solution, a 3, 3 '-dihydroxybenzaldehyde aqueous solution, a cationic polymer aqueous solution, a cationic polymer aqueous solution, a cationic polymer aqueous solution, a cationic polymer aqueous solution and a water solution. The preparation method comprises the following steps: mixing a 3, 3 '-dithiobis (propionyl hydrazide) (DTPH) aqueous solution and a dopamine modified MXene-bioactive inorganic material aqueous solution according to a volume ratio of (14-18): (1-6): (1-4): (1-4), and carrying out a Schiff base reaction to obtain the FGDM hydrogel. The FGDM hydrogel is injectable, self-healing and conductive, has temperature and oxidation reduction dual responsiveness, ROS (reactive oxygen species) removal capability, rapid hemostasis capability, good biocompatibility, relatively strong tissue adhesion and antibacterial property, and can promote the repair of infectious skin wounds of diabetic mice. The preparation method is simple, free of organic solvent residues, environment-friendly, convenient to operate and low in raw material cost.

Description

technical field [0001] The invention belongs to the technical field of biomedical materials, and relates to a two-dimensional MXene-inorganic-organic hybrid multifunctional hydrogel for promoting the healing of infectious diabetic wounds and a preparation method. Background technique [0002] The skin is the largest organ of the human body and the first barrier for the human body to protect itself. Impaired skin wound healing in diabetic patients results in high morbidity and mortality worldwide. Thus, restoration of skin integrity, homeostasis, and protective functions after injury is critical for human survival. Currently, dressings for wound treatment include cotton wool, bandages, gauze, and hydrogels. Among them, hydrogel scaffolds are biodegradable due to their rich water content and three-dimensional cross-linked network structure, which can keep the wound environment moist, promote oxygen exchange, absorb wound exudate, and avoid secondary trauma caused by dressing...

Claims

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Application Information

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IPC IPC(8): A61L26/00C08J3/075C08L71/00C08L5/08C08L79/02C08L77/04C08K9/04C08K3/14C08K5/372
CPCA61L26/008A61L26/0061A61L26/0066A61L26/0019A61L26/0023A61L26/0004C08J3/075A61L2300/412A61L2400/06A61L2400/04A61L2300/404C08J2371/00C08J2405/08C08J2479/02C08J2477/04C08K9/08C08K3/14C08K5/3725C08L71/00C08L5/08C08L79/02C08L77/04
Inventor 张秋禹杨作婷张宝亮周丽郑华
Owner NORTHWESTERN POLYTECHNICAL UNIV
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