Bone repair material as well as preparation method and application thereof

A technology for bone repair and scaffold materials, applied in the field of medical materials, can solve the problems of poor bone induction, increased surgical procedures, implantation risks and medical expenses, and inability to guarantee three-dimensional three-dimensionality, so as to promote regeneration and reconstruction, simplify Clinical treatment steps, the effect of shortening treatment time

Active Publication Date: 2022-06-03
健诺维(成都)生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

These materials can be used as a calcium source and osteoinductive effect during bone repair, but the osteoinductive effect is poor
Moreover, this kind of material is filled in the form of powder, and the three-dimensional shape cannot be guaranteed. Other materials need to be added to maintain the three-dimensional shape, which increases more surgical steps, implantation risks, and medical expenses.

Method used

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  • Bone repair material as well as preparation method and application thereof
  • Bone repair material as well as preparation method and application thereof
  • Bone repair material as well as preparation method and application thereof

Examples

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preparation example Construction

[0075] A preparation method of the above-mentioned bone repair material, comprising the following steps:

[0076] (1) mixing the bone meal, gelatin microspheres and collagen scaffold material in the core material raw material with water, putting it into a mold, and freeze-drying to obtain a core material;

[0077] (2) Mixing the gelatin microspheres and the collagen scaffold material in the raw material of the coating layer with water, adding the core material obtained in step (1), and performing freeze-drying after mixing. Further, the volume ratio of the core material and the raw material of the wrapping layer in step (2) is 1:(0.5-1.5).

[0078] Further, the preparation method of the bone repair material comprises the following steps:

[0079] (1) mixing the bone meal, gelatin microspheres and collagen scaffold material aqueous solution in the core material raw material, putting it into a mold, and freeze-drying to obtain a core material;

[0080] (2) Mixing the gelatin m...

Embodiment 1

[0092] 1) The bovine cancellous bone is cut into bone blocks, soaked in a calcium hydroxide solution with a concentration of 1.0 mol / L at 55° C. for 24 hours, detergent (triton-100) (mass ratio of bone block to triton-100 is 50: 1) Soak at room temperature for 24 hours, repeat once. After repeated rinsing with deionized water, immersed in 0.5mol / L hydrochloric acid solution for 24 hours, after repeated rinsing with deionized water, soaked in 3wt% alkaline phosphatase aqueous solution at 37°C for 24 hours, rinsed repeatedly with phosphate balanced salt solution, dried and pulverized Molecular sieve, made into bone meal with a particle size of 0.5-1.0mm;

[0093]2) Mix carboxymethyl cellulose, sodium alginate and collagen in proportion (mass ratio 1:1:2), add distilled water (the ratio of polymer mixture mass (gram) to solvent volume (ml) is 4:50-75 ) is made into a viscous solution as a stent material solution;

[0094] 3) Add medicinal gelatin to 10wt% lidocaine aqueous solu...

Embodiment 2

[0098] 1) Cut bovine cancellous bone into bone blocks, soak them in a sodium hydroxide solution with a concentration of 0.5 mol / L for 24 hours at 45° C. 10:1) Soak in solution for 24 hours at room temperature, repeat once. After repeated rinsing with deionized water, immersed in 0.5mol / L hydrochloric acid solution for 24 hours, after repeated rinsing with deionized water, immersed in 3wt% alkaline phosphatase solution at 37°C for 24 hours, rinsed repeatedly with phosphate balanced salt solution, dried and crushed Molecular sieve, made into bone meal with a particle size of 0.5-1.0mm;

[0099] 2) Mix carboxymethyl cellulose, sodium alginate and collagen in proportion (mass ratio 1:2:2), add distilled water (the ratio of polymer mixture mass grams to solvent volume milliliters is 4 grams: 50-75 milliliters) to make Viscous solution, as a solution for stent material;

[0100] 3) Add medicinal gelatin to 10wt% lidocaine solution (weight of gelatin (g): volume of lidocaine soluti...

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Abstract

The invention relates to a bone repair material as well as a preparation method and application thereof. The bone repair material comprises a core material and a wrapping layer wrapping the core material, the core material is prepared from raw materials including bone meal, gelatin microspheres and a collagen scaffold material; the wrapping layer is prepared from raw materials including gelatin microspheres and a collagen scaffold material; the collagen scaffold material is prepared from a macromolecular substance containing amino groups and a macromolecular substance containing carboxyl groups, the macromolecular substance containing the amino group is one or more of amino oligosaccharide, collagen, chitosan, a chitosan derivative and gelatin; the carboxyl-containing macromolecular substance is one or more of carboxymethyl cellulose, pectin or a derivative thereof, alginic acid or a derivative thereof, and hyaluronic acid or a derivative thereof. The bone repair material disclosed by the invention can effectively promote regeneration and reconstruction of bone tissue at a bone defect part, can effectively maintain a local three-dimensional space structure, and can also be used for in-situ hemostasis and pain relief pretreatment.

Description

technical field [0001] The invention relates to the field of medical materials, in particular to a bone repair material and a preparation method and application thereof. Background technique [0002] Bone is one of the largest tissues and organs in the human body. It bears the important responsibility of life activities, but it is the most easily damaged part. Every year, millions of patients with bone tissue defects need to undergo surgical treatment. However, the problem of bone defect repair has always been an orthopaedic problem. One of the problems doctors face. Bone transplantation is usually used to treat bone defects, but the materials for bone transplantation mainly include autologous bone, allogeneic bone, xenograft and various artificial bone graft substitutes. Allogeneic bone and xenogeneic bone have clinical rejection, cross infection and ethical issues; traditional bioceramics and polymer bone materials have good biocompatibility and certain osteoconductivity,...

Claims

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Application Information

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IPC IPC(8): A61L27/10A61L27/12A61L27/20A61L27/22A61L27/24A61L27/36A61L27/54A61L27/58A61L27/52
CPCA61L27/3608A61L27/365A61L27/222A61L27/24A61L27/10A61L27/12A61L27/20A61L27/54A61L27/58A61L27/52A61L2430/02A61L2300/402A61L2400/04A61L2430/12C08L89/00
Inventor 林永亮何海娜刘艳丽吴有陵罗锦荣
Owner 健诺维(成都)生物科技有限公司
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