Metal organic framework material with antioxidant activity
A metal-organic framework and anti-oxidant activity technology, which is applied in the direction of medical preparations with non-active ingredients, medical preparations containing active ingredients, anti-toxic agents, etc., to achieve the effect of high specific surface area
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[0031] The preparation process of this metal-organic framework material:
[0032] 1) At atmospheric pressure 28.7 mg HATP·6HCl, 10 mg Ru (PPh 3 ) 3 Cl 2 and 1 mL triethylamine dispersed in 20 mL deionized water, vigorously stirring the mixture to form a uniform dispersion solution;
[0033] 2) The dispersed solution is stirred and heated at 65 °C for two days to produce a black solid precipitation, and the black solid is obtained by centrifugation and filtration, and then the resulting solid is washed with deionized water;
[0034] 3) The solid is refluxed in acetone for 5 hours, and finally the black solid powder Ru-MOF is obtained by vacuum drying at 100 °C.
[0035] X-ray powder diffraction experiments were done with the X diffractometer of the model Rigaku Smartlab, from Figure 2 The X-ray powder diffraction pattern (PXDR) shows that the crystal surface (111), (210), (211), (221), (310), (411), (332), (430) show strong diffraction peaks, and the sharp diffraction peaks indicat...
Embodiment 1
[0038] Example 1 catalytic decomposition of hydrogen peroxide
[0039] 1.0 mg Of Ru-MOF was dispersed in 1 mL deionized water by sonication to prepare a 1 mg / mL sample solution; Take 10 μL of sample solution and add it to 1 mL hydrogen peroxide solution (10 mM) as the experimental group, set the hydrogen peroxide solution without adding sample liquid as the control group, respectively, at different time nodes, take 1 μL of liquid with NANO DROP to detect 240 nm absorbance, record the change of absorbance, and plot the decomposition curve of hydrogen peroxide by the ratio to the initial absorbance.
[0040] See Figure 5 It can be seen that with the passage of time, the content of hydrogen peroxide in the experimental group gradually decreased, and Ru-MOF had a significant effect on hydrogen peroxide decomposition.
Embodiment 2
[0041] Example 2 catalyzes the removal of superoxide anions
[0042] 1.0 mg Of Ru-MOF was dispersed in 1 mL deionized water by sonication to prepare a 1 mg / mL sample solution; Assays containing 200 μM riboflavin, 130 mM methionine and 700 μM nitrotetrazozoline were prepared with 25 mM of phosphate buffer, respectively; Take 0, 20, 40, 60, 80 and 100 μL of sample solution in an EP tube, and then add 350, 330, 310, 290 and 250 μL of phosphate buffer (25 mM) to dilute, followed by 50 μL of each of the above three detection reagents, and the resulting mixture contains 40, 80, 120, 160 and 200 ug / ml Ru-MOF, respectively.
[0043] The mixture is irradiated at room temperature with a lamp of constant light intensity for 5 min, another set of identical samples is kept in the dark as a blank control, detected with a UV-visible spectrophotometer, and a superoxide anion absorption curve is plotted. See absorption curve Figure 6 It can be seen that Ru-MOF has a significant absorption effect o...
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