Method for synthesizing molluscacide (Al pinumisoflavone) of pyrane isoflavone and its product

An isoflavone molluscicide and a synthesis method technology, which are applied in the directions of botanical equipment and methods, biocides, animal repellents, etc. to achieve good social benefits, overcome high toxicity, and improve the performance of molluscicides.

Inactive Publication Date: 2003-07-23
中国人民解放军南京军区联勤部军事医学研究所
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there is little interest in the development of new molluscicides in China at present, and there are even fewer reports on the chemical synthesis of natural plant molluscicides.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] Example 1: Synthesis of pyran-type isoflavone Alpinumisoflavone

[0041] All reagents used are commercially available AR grade reagents. Temperature is not corrected. IR spectrum was measured with SP-100 infrared spectrometer, 1 The H-NMR spectrum was measured with a Bruker-AC-E300 nuclear magnetic resonance instrument.

[0042] 1. Preparation of intermediate (II)

[0043] In a three-neck flask, add 1 mmol of phloroglucinol, 1 mmol of p-hydroxyphenylacetic acid, 1 g of molten anhydrous zinc chloride, and 1.9 ml of phosphorus oxychloride. Stir at room temperature for 5h. After the reaction was completed, the system was poured into crushed ice, and a precipitate precipitated out. Filtration, NaHCO 3 The solution was washed several times and recrystallized to obtain the product with a yield of 60%, mp.256-258°C.

[0044] 2. Preparation of intermediate (III)

[0045] In a three-neck flask, add 1 mmol of intermediate (II) and dissolve in 4 ml of DMF, carefully add 1....

Embodiment 2

[0048] Embodiment 2: Alpinumisoflavone preparation of pyran-type isoflavone

[0049] 1. Materials:

[0050] (1) Drug: pyran isoflavone Alpinumisoflavone original drug sodium salt

[0051] (2) Excipient: industrial gelatin

[0052] (3) Additives: acrylic resin, starch, etc.

[0053] 2. Preparation processing method

[0054] It is processed by pelletizing technology. Mix Alpinumisoflavone original drug and auxiliary agent evenly, roll it in the coating pan, blow it with hot air to keep it at about 25-65°C (preferably 35-40°C), and then spray the excipient solution on the solid mixture with a spray gun , while spraying and blowing, continuous operation.

[0055] 3. Quality inspection method

[0056] (1) Disintegration time limit experiment: a lifting disintegration instrument is used. When inspecting, hang the hanging basket on the metal bracket through the stainless steel shaft at the upper end, immerse it in a 1000ml beaker, and adjust the position of the hanging basket ...

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Abstract

A pyranisoflavone molluscacide "Alpinumisoflavone" is prepared from phloroglucinol and p-hydroxy phenylacetic acid through catalytic condensation to obtain deoxybenzoic acid derivative, closing loop reaction with dimethyl formamide to obtain isoflavone, condensation reaction on the intermediate 3-hydroxy-3-methyl-1,1-dimethoxybutane to obtain Alpinumisoflavone, granulating, and coating by high-molecular gelatin.

Description

technical field [0001] The invention relates to a method for synthesizing a molluscicide and a preparation thereof, in particular to a method for synthesizing a molluscicide of pyranyl isoflavones and a preparation thereof. Background technique [0002] Oncomelania is the only intermediate host of schistosomiasis and an indispensable biological condition for the transmission of schistosomiasis. The regional distribution of snails is consistent with that of schistosomiasis. In the south of my country, the river network is criss-cross, and the paddy fields are in patches. There are snails and the risk of schistosomiasis infection is extremely high. The measures have positive and far-reaching social and military significance for protecting the health of the people and the combat effectiveness of the troops. [0003] Molluscicides have the characteristics of saving manpower and quick effect. Over the past half a century, the research on molluscicides has made some progress. Com...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A01N43/90C07D493/02
Inventor 李洁
Owner 中国人民解放军南京军区联勤部军事医学研究所
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