Policresulen foam aerosol and its prepn process

A technology of polycresol and foam aerosol, which is applied in the direction of aerosol delivery, disease, drug combination, etc., and can solve problems such as unsanitary, patient discomfort, and inconvenient use

Inactive Publication Date: 2006-08-02
YANGTAI PHARMA SHANDONG
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, the commonly used dosage forms of polycresol sulfaldehyde in gynecology are suppositories, concentrates and sprays. Suppositories are solid preparations, which soften and dissolve slowly in the cavity, and the onset of action is slow, and the drug is not uniformly dispersed, and the local concentration is high. At the same time, it needs to be operated by hand when taking medication, which is unhygienic and easy to cross-contaminate. The patient has a foreign body sensation in the body, which brings discomfort to the patient.
The concentrated solution needs to be wiped with a cotton ball or diluted with water before being administered. The drug cannot fully contact the mucous membrane of the cavity, and the liquid is easy to flow in the cavity, which is also inconvenient to use.
Although the spray with water as the solvent can be directly sprayed on the local wo

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0077] Components: Weight: (%)

[0078] Polycresol 15.000

[0079] Sodium hydroxide 0.025

[0080] Tween-40 2.000

[0081] Sodium lauryl sulfate 4.000

[0082] Dioctyl sodium sulfosuccinate 0.100

[0083] Fragrance 0.025

[0084] Sodium metabisulfite 0.020

[0085] water 68.830

[0086] Difluorodichloromethane 10.000

[0087] method:

[0088] (1) Solution A: Weigh 20g of Tween-40, 40g of sodium lauryl sulfate, 1g of sodium dioctyl sulfosuccinate, and 0.2g of sodium metabisulfite, mix them, heat in a water bath or simmer until dissolved at 60-70°C, stir and mix uniform, spare;

[0089] (2) Solution B: Dissolve 150 g of polycresol raw material in 550 g of water, and slowly heat to the temperature of solution A; slowly add solution A to solution B while it is hot, and stir while adding to form an emulsion;

[0090] (3) When the temperature of the emulsion drops below 40°C, add 0.25g of essence and 0.25g of sodium hydroxide, add water to the full amount, and stir evenly;...

Embodiment 2

[0093] Components: Weight: (%)

[0094] Polycresol 15.000

[0095] Sodium bicarbonate 0.035

[0096] Triethanolamine 1.000

[0097] Stearic acid 3.000

[0098] Fragrance 0.025

[0099] Glycerin 5.000

[0100] Ethylparaben 0.150

[0101] Vitamin E 0.100

[0102] water 63.690

[0103] Dichlorotetrafluoroethane 4.000

[0104] Difluorodichloromethane 8.000

[0105] method:

[0106] (1) Solution A: Weigh 10g of triethanolamine, 30g of stearic acid, 50g of glycerin, and 1.5g of ethylparaben, mix them, heat them in a water bath or simmer until they dissolve at 60-70°C, stir and mix evenly, and set aside;

[0107] (2) Solution B: Dissolve 150 g of polycresol raw material in 510 g of water, and slowly heat to the temperature of solution A; slowly add solution A to solution B while it is hot, and stir while adding to form an emulsion;

[0108] (3) When the temperature of the emulsion drops below 40°C, add 0.25g of essence, 0.35g of sodium bicarbonate, 1.0g of vitamin E, add w...

Embodiment 3

[0111] Components: Weight: (%)

[0112] Polycresol 10.000

[0113] Sodium hydroxide 0.020

[0114] Triethanolamine Palmitate 3.000

[0115] Lanolin 0.200

[0116] Stearic acid 5.000

[0117] PVP 0.500

[0118] Fragrance 0.025

[0119] Propylparaben 0.100

[0120] Disodium salt of ethylenediaminetetraacetic acid 0.100

[0121] water 69.955

[0122] Difluorodichloromethane 12.000

[0123] method:

[0124] (1) Solution A: Weigh 30g of triethanolamine palmitate, 2g of lanolin, 50g of stearic acid, 5g of PVP, 1g of propylparaben, and 1g of disodium edetate, mix them, and heat in a water bath or simmer until dissolved 60-70°C, stir and mix evenly, set aside;

[0125] (2) Solution B: Dissolve 100 g of polycresol raw material in 560 g of water, and slowly heat to the temperature of solution A; slowly add solution A to solution B while it is hot, and stir while adding to form an emulsion;

[0126] (3) When the temperature of the emulsion drops below 40°C, add 0.25g of essen...

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PUM

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Abstract

The present invention discloses one kind of policresulen foam aerosol. The policresulen foam aerosol has softness, fineness, no excitation, excellent adsorption, excellent expansion and other advantages, can penetrate to mucous membrane goffer and other parts common medicine preparation can not reach to, and is suitable for use in body cavity. Clinic application shows that the policresulen foam aerosol is superior to corresponding spraying agent in treating cervicitis and vaginitis. The present invention also provides its preparation process.

Description

technical field [0001] The invention relates to pharmaceutical preparations, in particular to a polycresol foam aerosol and a preparation process. Background technique [0002] Polycresol is a topical drug. Its main functions are: (1) It can selectively act on diseased epithelial cells and ectopic columnar epithelium, causing them to coagulate, degenerate, fall off, and promote tissue repair, but has no effect on normal squamous epithelial cells, No scars are left after the treatment of cervical erosion. (2) Promote the recovery of the vaginal physiological environment, which is conducive to the re-breeding of the natural flora. (3) It can shrink small blood vessels and stop bleeding quickly. (4) It can kill a variety of pathogenic microorganisms, such as bacteria, molds, trichomonas and certain viruses. Clinically used in (1) gynecology, increased vaginal and cervical secretions caused by bacteria, trichomonas, and candida, vaginitis, cervicitis; treatment of bleeding a...

Claims

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Application Information

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IPC IPC(8): A61K31/765A61K9/12A61P15/02A61P15/00
Inventor 李铁军于云涛
Owner YANGTAI PHARMA SHANDONG
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