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Pharmaceutical composition, its preparation method and usage

A composition and drug technology, applied to the pharmaceutical composition of angina pectoris and ischemic stroke and its preparation, the treatment of shock, and the field of coronary heart disease, which can solve the problems of difficulty in controlling the quality of injections, easy occurrence of adverse reactions, and unstable efficacy of preparations To achieve the effect of improving drug efficacy and stability, reducing drug dosage, and reliable curative effect

Active Publication Date: 2006-10-11
HEBEI SHINEWAY PHARMA +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Shenmai injection is an injection preparation made from pure medicinal materials after extraction and simple purification. The production process is relatively backward, and the quality of the injection is difficult to control, resulting in unstable efficacy of the preparation, and the ineffective ingredients in the preparation can easily enter the body. produce adverse reactions, and even endanger the lives of patients
In addition, Shenmai injection must be diluted before use in clinical use, which is likely to cause secondary pollution

Method used

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  • Pharmaceutical composition, its preparation method and usage
  • Pharmaceutical composition, its preparation method and usage

Examples

Experimental program
Comparison scheme
Effect test

experiment example 1

[0028] The proportioning screening test of experimental example 1 composition

[0029] (1) Comparison of effects on myocardial ischemia

[0030] 40 SD rats, male, weighing 250-350 g, were randomly divided into 4 groups: blank control group (equal volume normal saline), Shenmai group A (32:1, 20 mg / kg), group B (16:1, 20mg / kg), group C (4:1, 20mg / kg), group D (2:1, 20mg / kg). 6 rats / group were anesthetized by intraperitoneal injection of pentobarbital (30mg / Kg), fixed in supine position, endotracheal intubation, connected to ventilator, tidal volume 1ml, frequency 14 breaths / min, respiratory ratio 3:1. Adjust the physiological recorder, intubate the right common carotid artery, and connect a pressure transducer to measure arterial systolic blood pressure (SBP) and diastolic blood pressure (DBP). Connect limb leads to measure ECGII, and record the normal values ​​of each parameter after stabilization. The left chest was shaved and disinfected. Along the left midline of the cla...

experiment example 2

[0045] Experimental Example 2 Pharmacodynamic Screening

[0046] (1) Effects on cardiogenic shock caused by coronary artery ligation in anesthetized open-chest dogs

[0047] Thirty hybrid dogs were divided into 5 groups, 6 dogs in each group. The control group was given equal volume of vehicle control, the positive drug group was given Shenmai injection 3.2ml / kg (640mg crude drug / kg), and the experimental component was Shenmai composition (red ginseng extract: Ophiopogon japonicus extract 4:1) 4mg / kg dose group, all adopt slow infusion. Anesthetized with pentobarbital sodium 30mg / kg i.v., dorsal position fixed, neck skin incision, endotracheal intubation, connected to an electric ventilator, isolated right carotid artery, connected to an AP-601G amplifier, and measured blood pressure. After the experiment, the heart was removed, and the whole heart was weighed, and the roots of the great vessels and atrium were cut along the coronary sulcus, and the left ventricle was weigh...

Embodiment 1

[0066] Embodiment 1: Preparation of Shenmai Common Tablets

[0067] Take the red ginseng medicinal material, add 6 times the amount of crude drug with 50% ethanol to extract by heating and reflux for 0.5 hour, filter, and the filtrate is set aside, add 6 times the amount of 50% ethanol to the medicinal residue and extract 4 times, each time for 0.5 hour, filter, The four filtrates were combined, concentrated under reduced pressure, and the concentrated solution was placed at room temperature, slowly injected into a D101 macroporous adsorption resin column (the ratio of medicinal materials to dry resin was 3:1), and first eluted with 10 times the column volume of deionized water, and then Use 5 times of column volume for elution with 30% ethanol, discard 30% eluent, then elute with 70% ethanol, collect 60% of column volume for 6 times of column volume, recover ethanol and concentrate, and vacuum dry the concentrate , crushed to obtain red ginseng extract. Take Ophiopogon japon...

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Abstract

The invention discloses a pharmaceutical composition, its preparing process and use, wherein the composition comprises red ginseng extract and ophiopogon root extract by a predetermined proportion, and can be used for treating cardiogenic shock and hemorrhagic shock.

Description

field of invention [0001] The present invention relates to a pharmaceutical composition and its preparation method and application, in particular to a pharmaceutical composition for treating shock, coronary heart disease, angina pectoris and ischemic cerebral apoplexy, its preparation method and application. Background technique [0002] Shenmai injection has been on the market in China for nearly 30 years, and now there are many manufacturers producing this variety, and they have achieved good social and economic benefits. In recent years, the state has increased the intensity of safety requirements for injections, and put forward higher requirements for the production process and quality control of injections. Shenmai injection is an injection preparation made from pure medicinal materials after extraction and simple purification. The production process is relatively backward, and the quality of the injection is difficult to control, resulting in unstable efficacy of the p...

Claims

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Application Information

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IPC IPC(8): A61K36/8968A61K9/08A61K9/16A61K9/19A61K9/20A61K9/48A61P9/02A61P9/10
Inventor 屠鹏飞齐学兵张彤梅姜勇逄剑岳洪利
Owner HEBEI SHINEWAY PHARMA
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