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Method for producing organic acid ammonium salt solution

A technology of ammonium organic acid and organic acid, applied in fermentation and other directions, can solve the problem of few evaluation of neutralizers

Inactive Publication Date: 2006-12-13
MITSUBISHI CHEM CORP +1
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0017] As mentioned above, magnesium, although an essential metal ion for microbial reactions, is only permitted for very limited purifications and has therefore been little evaluated as a neutralizing agent

Method used

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  • Method for producing organic acid ammonium salt solution
  • Method for producing organic acid ammonium salt solution
  • Method for producing organic acid ammonium salt solution

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0095] Embodiment 1 adopts the salt exchange of ammonia

[0096] (1) Preparation of magnesium succinate solution (magnesium succinate concentration 12.3% by weight, 30kg)

[0097] 25.35 kg of distilled water was added to a 100 L stirred vessel and stirred with an anchor blade at 30 rpm. The stirring vessel was controlled to normal temperature by passing water through the interlayer. A suspension was prepared by adding 1.54 kg of magnesium hydroxide (Wako Pure Chemical Industries, Ltd.) to the stirring tank. While monitoring the temperature of the suspension, 3.12 kg of succinic acid (Wako Pure Chemical Industries, Ltd.) was gradually added to the suspension. The neutralization reaction provided 30 kg of an aqueous solution of magnesium succinate.

[0098] (2) Salt exchange reaction using ammonia

[0099]After the above operation, 25% ammonia water (Wako Pure Chemical Industries, Ltd.) was mixed into the magnesium succinate aqueous solution (30 kg) for salt exchange. The m...

Embodiment 2

[0113] Embodiment 2 adopts the salt exchange of ammonium carbonate

[0114] (1) Synthesis of magnesium succinate solution (magnesium succinate concentration 12.3%, 10kg)

[0115] 8.45 kg of distilled water was added to a 15 L stirred vessel and stirred with a paddle blade at 200 rpm. The stirring container was controlled at normal temperature by passing water through the interlayer. A suspension was prepared by adding 0.51 kg of magnesium hydroxide (Wako Pure Chemical Industries, Ltd.) to the stirring tank. While monitoring the temperature of the suspension, 1.04 kg of succinic acid (Wako Pure Chemical Industries, Ltd.) was gradually added to the suspension. This neutralization reaction provided 10 kg of an aqueous solution of magnesium succinate.

[0116] (2) Salt exchange reaction using ammonium carbonate

[0117] After the above operation, ammonium carbonate (Wako Pure Chemical Industries, Ltd.) was mixed into the magnesium succinate aqueous solution (10 kg) for salt ex...

Embodiment 3

[0133] Embodiment 3 utilizes fermentation to carry out the preparation of magnesium succinate solution and the preparation of double salt

[0134] (1) Preparation of bacterial cells

[0135] Add 100 mL of culture medium into a 500 mL Erlenmeyer flask, and heat the culture medium at 120°C for 20 minutes to sterilize, then cool to room temperature. The culture medium contains 4 g of urea, 14 g of ammonium sulfate, 0.5 g of diphosphate Potassium hydrogen, 0.5g dipotassium hydrogenphosphate, 0.5g magnesium sulfate heptahydrate, 20mg ferrous sulfate heptahydrate, 20mg manganese sulfate hydrate, 200μg D-biotin, 200μg thiamine chloride, 1g yeast extract and 1g casamino acids. Then, 4 mL of pre-sterilized 50% glucose aqueous solution and 50 μL of filter-sterilized 5% kanamycin solution were added thereto. The Brevibacterium flavum MJ233 / FRD / PC / ΔLDH strain constructed in the following Reference Example was inoculated therein, and seed culture was performed at 30° C. for 24 hours. In...

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Abstract

Organic acid ammonium solution is produced by the steps of obtaining a fermentation broth containing organic acid magnesium by using an organic acid-producing microorganism in the presence of a magnesium compound, producing organic acid ammonium and a magnesium compound by subjecting the organic acid magnesium contained in the fermentation broth to salt-exchange using an ammonia compound, and separating the produced magnesium compound to obtain organic acid ammonium solution.

Description

technical field [0001] The present invention relates to a method of making ammonium organic acid solutions, such as ammonium succinate solutions. More specifically, the present invention relates to a process for the manufacture of ammonium solutions of organic acids suitable for the manufacture of organic acids by microbial conversion from raw materials of biological origin such as glucose, dextrose and cellulose. Background technique [0002] Organic acids include fumaric acid, maleic acid, malic acid, and succinic acid, among others. Among them, succinic acid and its derivatives are widely used as raw materials for polymers such as biodegradable polyesters and polyamides or as raw materials for foods, medicines, or cosmetics. [0003] Currently, organic acids such as succinic acid can be produced industrially by hydrogenation of maleic acid, which is a raw material derived from petroleum. Recently, there has been research on the production of organic acids from plant-der...

Claims

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Application Information

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IPC IPC(8): C12P7/46
Inventor 磯谷笃志池田英雄山岸兼治青山龙介
Owner MITSUBISHI CHEM CORP
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