Preparation of new drug delivery system based on liquid surface spray method

A technology of delivery system and spray method, which is applied in the application of liquid surface spray method in drug delivery system, and the application field of preparing a new type of drug delivery system based on liquid surface spray method in industrialized large-scale production, which can solve the problem of unseen liquid In order to achieve the effect of similar in vitro release properties, good reproducibility, and uniform particle size distribution

Inactive Publication Date: 2011-12-14
SHENYANG PHARMA UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

As can be seen above, there is no mention of the application of the liquid surface spray method in microsphere preparations in the literature, nor is there any mention of the application of the liquid surface spray method in microparticle preparations, especially the industrialized production problems that this method emphasizes to solve. various reports

Method used

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  • Preparation of new drug delivery system based on liquid surface spray method
  • Preparation of new drug delivery system based on liquid surface spray method
  • Preparation of new drug delivery system based on liquid surface spray method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] The preparation of embodiment 1 vinpocetine lactic acid-glycolic acid copolymer (PLGA) microsphere

[0016] At room temperature, accurately weigh 50 mg of the drug Vinpocetine and 200 mg of the polymer PLGA dissolved in 10 ml of dichloromethane as the atomization phase, and measure 50 ml of 1% PVA aqueous solution as the aqueous phase receiving solution. Spray the atomized phase into the receiving solution at a flow rate of 2.0ml / min and a pressure of 0.15MPa through a spray device, stir and volatilize at room temperature, centrifuge at 3000r / min, and wash to collect. The particle size distribution of the microspheres was determined to be narrow, and the encapsulation efficiency was 83.3%.

Embodiment 2

[0017] The preparation of embodiment 2 metformin hydrochloride gelatin microspheres

[0018] Weigh 180mg of metformin hydrochloride and add it to 10ml of 20% gelatin aqueous solution kept in a 50°C water bath as an atomization phase; at the same time, add an appropriate amount of glutaraldehyde to 50ml of a liquid containing 1% Span-80 kept in a 50°C water bath In paraffin, as the receiving liquid; spray the atomized phase into the receiving liquid at a flow rate of 15.0ml / min and a pressure of 0.35MPa through a spray device, and at the same time stir at room temperature, after cross-linking, add 20ml of isopropanol, fully dehydrated, pump rate, washed with isopropanol, anhydrous ether, and anhydrous ethanol, respectively, and dried in vacuum. Compared with the traditional method, the particle size distribution of microspheres is narrow, and the encapsulation efficiency and drug dosage are both improved.

Embodiment 3

[0019] The preparation of embodiment 3 intravenous injection fat emulsion (blank emulsion)

[0020]

[0021] Operation: Add phospholipid (Lecithin170) to soybean oil kept warm in a water bath at 70°C to form an oil phase (receiving solution). Add glycerin to an appropriate amount of water and keep warm in a water bath at 70°C to form a water phase (atomized phase); Spray the atomized phase into the receiving liquid at a flow rate of 4ml / min and a pressure of 0.2MPa to form colostrum, and then disperse it by ultrasonic to form a stable emulsion. Compared with the traditional method, the prepared emulsion is more stable.

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Abstract

The invention provides a delivery system for preparing novel drugs based on a liquid surface spraying method, which is a novel microparticle preparation method with great industrialization prospects. The delivery system of the new drug is prepared based on the liquid surface spray method. The solution containing the carrier material is miscible or suspended with the drug or the drug solution, and then atomized, and sprayed into the receiving liquid to form a particle preparation. The flow rate of the atomized liquid is 0.01-100ml / min, spray pressure 0.1-0.5MPa, preparation temperature 5-100°C. The invention has high yield and good method stability, and the whole preparation process of the invention is completed by instruments, which avoids the difference of human factors and greatly improves the yield. The particle size distribution is uniform and reproducible.

Description

technical field [0001] The present invention relates to the application of a new preparation method in the drug delivery system, specifically the application of the liquid surface spray method in the drug delivery system, especially the application of a new drug delivery system based on the liquid surface spray method in industrialized mass production. in the application. Background technique [0002] With the continuous progress and development of science and technology, the status of microparticle preparations in drug delivery systems is becoming more and more important. Microparticle preparations have a certain degree of sustained release and passive targeting, and these characteristics are mainly achieved by controlling the particle size of the microparticle preparations. Therefore, in order to realize some characteristics of the microparticle preparation, it is necessary to strictly and effectively control the particle size distribution of the microparticle preparation...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/107A61K9/127A61K9/14A61K9/16A61K9/50A61K9/20A61K9/48A61J3/00
Inventor 潘卫三唐海孟晋
Owner SHENYANG PHARMA UNIVERSITY
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