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Mesoporous biological glass fiber material and its prepn and application

A glass fiber and mesoporous technology, applied in the field of biomedical materials, achieves the effects of simple and easy operation, mild reaction conditions, and cheap and easy-to-obtain raw materials

Inactive Publication Date: 2007-01-03
FUDAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there is no report on the preparation of MBG fiber materials at home and abroad.

Method used

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  • Mesoporous biological glass fiber material and its prepn and application
  • Mesoporous biological glass fiber material and its prepn and application
  • Mesoporous biological glass fiber material and its prepn and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] 4.0g nonionic surfactant EO 20 PO 70 EO 20 (P123), 1.4g calcium nitrate (Ca(NO 3 ) 4 4H 2(2), 6.7g tetraethyl orthosilicate (TEOS), 0.72g triethyl phosphate (TEP) is dissolved in 60g ethanol, and adds 1.3g 4M hydrochloric acid solution, stirs 24h at room temperature, obtains stable sol; Open and volatilize at room temperature until the viscosity of the solution reaches the level where fibers can be sprayed; pour the sol into the spray gun, spray the fibers onto the silicon wafer, and age for about 72 hours to make the hydrolysis-polycondensation reaction fully proceed and form a gel. The glue is placed in a desiccator. The gel block obtained after drying is calcined at 700° C. for 5 hours in a muffle furnace to obtain a two-dimensional hexagonal phase (p6mm structure) mesoporous bioglass fiber material.

Embodiment 2

[0034] 4.0g nonionic surfactant EO 20 PO 70 EO 20 (P123), 0.95g calcium nitrate (Ca(NO 3 ) 4 4H 2 O), 6.7g tetraethyl orthosilicate (TEOS), 0.72g triethyl phosphate (TEP), 0.40g magnesium chloride (MgCl 2 ·6H 2 O) Dissolve in 60g of ethanol, add 1.3g of 2M hydrochloric acid solution, stir at room temperature for 20 hours to obtain a stable sol; volatilize the sol at room temperature until the viscosity of the sol reaches the level where fibers can be sprayed, and pour the sol into the spray gun , Spray the fiber onto a silicon wafer that can withstand high temperature, and age it for about 80 hours to make the hydrolysis-polycondensation reaction fully proceed to form a gel, and place the gel in a desiccator. The gel block obtained after drying is calcined at 600° C. for 4 hours in a muffle furnace to obtain a two-dimensional hexagonal phase (p6mm structure) mesoporous bioglass fiber material.

Embodiment 3

[0036] 4.0g nonionic surfactant EO 20 PO 70 EO 20 (P123), 0.95g calcium nitrate (Ca(NO 3 ) 4 4H 2 O), 6.7g tetraethyl orthosilicate (TEOS), 0.72g triethyl phosphate (TEP), 0.681g n-butyl titanate were dissolved in 60g ethanol, and 1.3g 3M hydrochloric acid solution was added, stirred at room temperature for 28h, A stable sol was obtained. Volatilize the sol at room temperature until the viscosity of the solution reaches the level where fibers can be sprayed. Pour the sol into a spray gun to spray fibers. Spray the fibers onto silicon wafers that can withstand high temperatures. Aging for about 60 hours, hydrolysis-polycondensation The reaction fully proceeds to form a gel, which is placed in a desiccator and fully dried. The gel block obtained after drying was calcined at 550°C for 6 hours in a muffle furnace to obtain a two-dimensional hexagonal phase (p6mm structure) mesoporous bioglass fiber material, but without the addition of TiO 2 The order of the time structure ...

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PUM

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Abstract

The present invention belongs to the field of biomedical material technology, and is especially one kind of mesoporous biological glass fiber material with bone repairing bioactivity and its preparation process. The mesoporous biological glass fiber material is prepared through spraying sol in controlled viscosity by means of template of surfactant. It has controllable composition, has the main components of SiO2, CaO and P2O5 and may have also TiO2, MgO, etc. added. It has controllable mesoporous structure of pore size 1-30 nm, specific surface area 100-1000 sq m / g, pore volume 0.3-1.5 cu cm / g. It possesses controllable macroscopic fiber shape, excellent osteogenesis activity and cell activity, and excellent biocompatibility and degrading performance. Therefore, the mesoporous biological glass fiber material may be used as bone repairing filler material and rack material.

Description

technical field [0001] The invention belongs to the technical field of biomedical materials, and in particular relates to a mesoporous biological glass fiber material with controllable chemical composition, macroscopic size and mesoscopic structure, and a preparation method and application thereof. Background technique [0002] Bone defect is a common clinical disease in trauma surgery, orthopedics and oral and maxillofacial surgery. In modern medicine, artificial bone materials are intersected with other bone substitute materials and have many advantages: completely excluding the possibility of immune rejection and disease transmission, convenient for standardized mass production, and easier to control the quality, so it is an ideal bone defect Restoration materials. [0003] Among the inorganic biomaterials with the function of repairing bone defects, there are currently two types of inorganic biomaterials that have been studied more——hydroxyapatite (HA) and bioglass (BG)...

Claims

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Application Information

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IPC IPC(8): A61L27/28C03C3/097C03C3/06C03B37/06
Inventor 余承忠易静黄晓辉严晓霞
Owner FUDAN UNIV
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