Mesoporous biological glass fiber material and its prepn and application

A glass fiber and mesoporous technology, applied in the field of biomedical materials, achieves the effects of simple and easy operation, mild reaction conditions, and cheap and easy-to-obtain raw materials

Inactive Publication Date: 2007-01-03
FUDAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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  • Mesoporous biological glass fiber material and its prepn and application
  • Mesoporous biological glass fiber material and its prepn and application
  • Mesoporous biological glass fiber material and its prepn and application

Examples

Experimental program
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Example Embodiment

[0031] Example 1

[0032] Add 4.0g non-ionic surfactant EO 20 PO 70 EO 20 (P123), 1.4g calcium nitrate (Ca(NO 3 ) 4 ·4H 2O), 6.7g of ethyl orthosilicate (TEOS), 0.72g of triethyl phosphate (TEP) were dissolved in 60g of ethanol, and 1.3g of 4M hydrochloric acid solution was added and stirred at room temperature for 24h to obtain a stable sol; Open and volatilize at room temperature until the viscosity of the solution reaches the level of spraying fibers; pour the sol into the spray gun, spray the fibers onto the silicon wafer, and age for about 72 hours to allow the hydrolysis-polycondensation reaction to proceed fully to form a gel and condense The glue is placed in a desiccator. After drying, the obtained gel block is calcined in a muffle furnace at 700°C for 5 hours to obtain a mesoporous bioglass fiber material with a two-dimensional hexagonal phase (p6mm structure).

Example Embodiment

[0033] Example 2

[0034] Add 4.0g non-ionic surfactant EO 20 PO 70 EO 20 (P123), 0.95g calcium nitrate (Ca(NO 3 ) 4 ·4H 2 O), 6.7g ethyl orthosilicate (TEOS), 0.72g triethyl phosphate (TEP), 0.40g magnesium chloride (MgCl 2 ·6H 2 O) Dissolve in 60g ethanol, add 1.3g 2M hydrochloric acid solution, and stir at room temperature for 20 hours to obtain a stable sol; open the sol at room temperature to volatilize until the viscosity of the sol reaches the level of spraying fibers, pour the sol into the spray gun , The fiber is sprayed onto a silicon wafer that can withstand high temperatures, and aged for about 80 hours to fully carry out the hydrolysis-polycondensation reaction to form a gel, and place the gel in a dryer. After drying, the obtained gel block is calcined in a muffle furnace at 600°C for 4 hours to obtain a mesoporous bioglass fiber material with a two-dimensional hexagonal phase (p6mm structure).

Example Embodiment

[0035] Example 3

[0036] Add 4.0g non-ionic surfactant EO 20 PO 70 EO 20 (P123), 0.95g calcium nitrate (Ca(NO 3 ) 4 ·4H 2 O), 6.7g ethyl orthosilicate (TEOS), 0.72g triethyl phosphate (TEP), 0.681g n-butyl titanate dissolved in 60g ethanol, and added 1.3g 3M hydrochloric acid solution, stirred at room temperature for 28h, A stable sol is obtained. Open the sol at room temperature to volatilize until the viscosity of the solution reaches the level of spraying fibers. Pour the sol into the spray gun to spray the fibers, spray the fibers on the silicon wafers that can withstand high temperature, and age for about 60 hours to hydrolyze and polycondensate. The reaction proceeds sufficiently to form a gel, and the gel is placed in a desiccator to fully dry. After drying, the gel block is calcined in a muffle furnace at 550°C for 6 hours, and a two-dimensional hexagonal phase (p6mm structure) mesoporous bioglass fiber material can be obtained, but TiO is not added. 2 The order of time s...

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Abstract

The present invention belongs to the field of biomedical material technology, and is especially one kind of mesoporous biological glass fiber material with bone repairing bioactivity and its preparation process. The mesoporous biological glass fiber material is prepared through spraying sol in controlled viscosity by means of template of surfactant. It has controllable composition, has the main components of SiO2, CaO and P2O5 and may have also TiO2, MgO, etc. added. It has controllable mesoporous structure of pore size 1-30 nm, specific surface area 100-1000 sq m/g, pore volume 0.3-1.5 cu cm/g. It possesses controllable macroscopic fiber shape, excellent osteogenesis activity and cell activity, and excellent biocompatibility and degrading performance. Therefore, the mesoporous biological glass fiber material may be used as bone repairing filler material and rack material.

Description

technical field [0001] The invention belongs to the technical field of biomedical materials, and in particular relates to a mesoporous biological glass fiber material with controllable chemical composition, macroscopic size and mesoscopic structure, and a preparation method and application thereof. Background technique [0002] Bone defect is a common clinical disease in trauma surgery, orthopedics and oral and maxillofacial surgery. In modern medicine, artificial bone materials are intersected with other bone substitute materials and have many advantages: completely excluding the possibility of immune rejection and disease transmission, convenient for standardized mass production, and easier to control the quality, so it is an ideal bone defect Restoration materials. [0003] Among the inorganic biomaterials with the function of repairing bone defects, there are currently two types of inorganic biomaterials that have been studied more——hydroxyapatite (HA) and bioglass (BG)...

Claims

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Application Information

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IPC IPC(8): A61L27/28C03C3/097C03C3/06C03B37/06
Inventor 余承忠易静黄晓辉严晓霞
Owner FUDAN UNIV
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