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Preparation method and use of single, compound arsenic with bio-effect

A biological and elemental arsenic technology, applied in botanical equipment and methods, medical preparations containing active ingredients, applications, etc., can solve the problems of low bioavailability, large toxic and side effects, and large particles, and achieve good stability. , the use of a wide range, the effect of small particle size

Inactive Publication Date: 2007-02-14
ZHEJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there are still many problems in the clinical application of traditional arsenic preparations, such as large toxic and side effects, large particles, and low bioavailability. Therefore, while seeing the clinical application value of arsenic-containing traditional Chinese medicines,

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] 1) Diarsenic trioxide (As 2 o 3 ) dissolved in 0.1moL / L aqueous sodium hydroxide solution, As 2 o 3 The solid-to-liquid ratio with sodium hydroxide solution is 1g: 1L;

[0020] 2) Set the weight to As 2 o 3 10 times of sodium carboxymethyl cellulose, prepared into an aqueous solution of sodium carboxymethyl cellulose with a weight volume concentration of 0.1g: 1L, slowly adding the As in step 1) 2 o 3 In the aqueous solution, under stirring, slowly add the molar ratio of As 2 o 3 3 times vitamin C, adjust the pH of the reaction system to 4, and react at room temperature for 1 hour;

[0021] 3) The reaction solution in step 2) is an elemental arsenic sol with biological effects.

Embodiment 2

[0023] 1) Arsenic trisulfide (As 2 S 3 ) is dissolved in 10moL / L sodium hydroxide aqueous solution, the solid-liquid ratio of arsenide and sodium hydroxide solution is 100g: 1L;

[0024] 2) Set the weight to As 2 S 3 1000 times of polyvinylpyrrolidone, prepared into an aqueous solution of polyvinylpyrrolidone with a weight volume concentration of 100g: 1L, slowly adding the As in step 1) 2 S 3 In the aqueous solution, under stirring, slowly add the molar ratio of As 2 S 3 10 times of potassium borohydride, adjust the pH of the reaction system to 9, and react at room temperature for 10 hours;

[0025] 3) Centrifuge the reaction solution obtained in step 2) under a nitrogen atmosphere, wash it with water, and then dehydrate it by centrifugation. The obtained filter cake is vacuum-dried at a temperature below 80° C. and crushed to 400 meshes to obtain elemental arsenic with biological effects. .

Embodiment 3

[0027] 1) Diarsenic disulfide (As 2 S 2 ) dissolved in 5moL / L aqueous sodium hydroxide solution, As 2 S 2 The solid-to-liquid ratio with sodium hydroxide solution is 50g: 1L;

[0028] 2) Set the weight to As 2 S 2 100 times of chitosan is prepared into the chitosan acetic acid aqueous solution whose weight volume concentration is 10g: 1L, and slowly adds the As of step 1) 2 S 2 In the aqueous solution, under stirring, slowly add the molar ratio of As 2 S 2 7 times of hydrazine hydrate, adjust the pH of the reaction system to 8.5, and react at room temperature for 5 hours;

[0029] 3) The reaction solution obtained in step 2) is filtered and separated under an argon atmosphere, washed with water, filtered and dehydrated, and the obtained filter cake is vacuum-dried at a temperature below 80°C and crushed to 500 mesh to obtain a simple substance with biological effects arsenic.

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Abstract

The invention discloses a method for simple substance arsenic with biology effect and the application. It generates simple substance arsenic by reduction reaction in the colloid system with the existence of protection agent that plays a role of bi-template, dispersing and stabilizing simple substance. The mineral used as carrier supplies large scale surface for the dispersing of simple substance to make it has small diameter, narrow distribution and good stability. The invention has the advantages of low toxicity, high efficiency. It could be used as feed additive or pesticide, and also could be used to make health products and medication for cure tumor.

Description

technical field [0001] The invention relates to a preparation method and application of elemental arsenic with biological effects. Background technique [0002] Arsenic is a metalloid element, which has the properties of amphoteric elements, and the non-metallic properties are stronger. Arsenic is a very dispersed element, and it is rarely found in natural state in nature, mainly in the form of sulfide ore. The toxicity of arsenic compounds is related to its solubility in water. Elemental arsenic is insoluble in water, so it is non-toxic. Arsenic disulfide and arsenic trisulfide have little water solubility and low toxicity. Arsenic trioxide is easily soluble in water and extremely toxic. The toxicity of arsenic compounds decreases in the following order: arsine>As 2 o 3 > Arsenous acid > Arsenic acid > Compounds of arsenic (arsenic with four positively charged organic groups) > Elemental arsenic. Trivalent arsenic compounds are more toxic than pentavalent...

Claims

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Application Information

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IPC IPC(8): C22B30/04C22B3/00A01N59/22A61K33/36
CPCY02P10/20
Inventor 胡彩虹徐勇夏枚生张红梅朱兴一
Owner ZHEJIANG UNIV