5-aminolevulinic acid phosphate, method for producing the same and use thereof

A technology of aminolevulinic acid phosphate and aminolevulinic acid, applied in the directions of botanical equipment and methods, chemical instruments and methods, preparation of organic compounds, etc., can solve the problem of not separating 5-aminolevulinic acid nitrate, The color of the fruit is not bright enough, the nozzle of the sprayer is blocked, etc., to achieve the effect of excellent permeability, excellent heat resistance, and high decomposition temperature

Active Publication Date: 2011-04-20
COSMO ALA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] In addition, although 5-aminolevulinic acid hydrochloride is used in the field of plants (see Patent Document 8), when it is used in combination with fungicide ingredients commonly used in plants such as silver nitrate, etc., in some cases, by 5-Aminolevulinic acid hydrochloride reacts with silver nitrate to produce silver chloride precipitate, because there is a possibility that the nozzle of the sprayer is blocked and the spraying cannot be done, so be very careful in operation
Furthermore, in the case where an aqueous solution of 5-aminolevulinic acid hydrochloride is directly applied to the fruit, when chloride ions are present, the color of the fruit sometimes becomes less vivid
[0010] In addition, although an aqueous solution containing 5-aminolevulinic acid ions and nitrate ions has been proposed, 5-aminolevulinic acid nitrate has not been isolated (see Non-Patent Document 6)

Method used

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  • 5-aminolevulinic acid phosphate, method for producing the same and use thereof
  • 5-aminolevulinic acid phosphate, method for producing the same and use thereof
  • 5-aminolevulinic acid phosphate, method for producing the same and use thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0099] Preparation of 5-aminolevulinic acid phosphate

[0100] 180 ml of strongly acidic ion exchange resin (AMBERLITE IR 120B Na, manufactured by Japan Organo Co., Ltd.) was loaded into the column. The used ion exchange resin is an ion exchange resin converted from sodium ion type to hydrogen ion type through hydrochloric acid treatment. Then, 20.00 g (119 mmol) of 5-aminolevulinic acid hydrochloride was dissolved in 1000 ml of ion-exchanged water, and the solution was passed through the column, and then 1000 ml of ion-exchanged water was passed through the column. Next, 1N ammonia water was slowly passed through the column, and 346ml of yellow eluent was collected. The collected eluate was added to 16ml, 85% phosphoric acid (H 3 PO 4 , 238mmol), and concentrated using an evaporator. 400 ml of acetone was added to the concentrate, vigorously stirred with a stirrer, and then left to stand at 4°C for 16 hours. The precipitated solid was recovered by suction filtration, and...

Embodiment 2

[0112] Preparation of 5-aminolevulinic acid (di-n-butyl phosphate) salt

[0113] 180 ml of strongly acidic ion exchange resin (AMBERLITE IR 120B Na, manufactured by Japan Organo Co., Ltd.) was loaded into the column. The used ion exchange resin is an ion exchange resin converted from sodium ion type to hydrogen ion type through hydrochloric acid treatment. Then, 20.00 g (119 mmol) of 5-aminolevulinic acid hydrochloride was dissolved in 1000 ml of ion-exchanged water, and the solution was passed through the column, and then 1000 ml of ion-exchanged water was passed through the column. Next, 1N ammonia water was slowly passed through the column, and 321 ml of yellow eluent was collected. The collected eluate was added to 50.00 g (238 mmol) of di-n-butyl phosphate, and concentrated using an evaporator. 400 ml of acetone was added to the concentrate, and stirred vigorously with a stirrer, and then the mixture was allowed to stand at -25°C for 16 hours. The precipitated solid wa...

Embodiment 3

[0117] Odor determination of 5-aminolevulinic acid phosphate

[0118] 5 subjects directly smelled the aqueous solution of 5-aminolevulinic acid phosphate prepared in Example 1 (a mixture of column eluate and phosphoric acid) and its solids, and evaluated their odors according to the following criteria. The results are shown in Table 1.

[0119] evaluation standard:

[0120] 0: No smell.

[0121] 1: Smelly but not unpleasant.

[0122] 2: Bad smell.

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Abstract

A 5-aminolevulinic acid salt which is useful in the fields of microorganisms, fermentation, animals, medical science, plants and so on; a process for producing the same; a medicinal composition containing the same; and a plant vitalizer composition containing the same.

Description

technical field [0001] The present invention relates to: 5-aminolevulinic acid salt, which can be used in the fields of microorganisms, fermentation, animals, medicines, plants, etc.; a method for preparing the salt; a pharmaceutical composition containing the salt; and a plant activator containing the salt combination. Background technique [0002] It is known that 5-aminolevulinic acid can be used in the field of microbial fermentation for VB 12 and the preparation of heme enzyme, microbial culture, porphyrin preparation, etc.; in the field of animal therapy, it can be used for the treatment of infectious diseases (see non-patent literature 1), sterilization, diagnosis of diseases caused by Haemophilus, Raw materials as derivatives, hair removal, rheumatism treatment (see Non-Patent Document 2), cancer treatment (see Non-Patent Document 3), thrombosis treatment (see Non-Patent Document 4), diagnosis in cancer surgery (see Non-Patent Document 5 ), animal cell culture, UV ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07C225/06A01N25/02A01N37/44A61K49/00C07C221/00C07C309/30C07F9/11
Inventor 立谷尚久西川诚司肥后麻衣田中彻石塚昌宏冈田秀树
Owner COSMO ALA CO LTD
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