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Pufa covered implants

a technology of metal implants and spherical layers, applied in the field of metal implants, can solve the problems of variation in the bond strength between the coating and the metallic substaret, affecting the success of the implant, and non-uniform layer thickness, so as to facilitate the control of hard and/or mineralized tissue adhesion, improve the adhesion of hard and/or mineralized tissue, and improve the effect of bone addition to the implant surfa

Inactive Publication Date: 2011-07-07
NUMAT BIOMEDICAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

[0016]The present invention for the first time describes a metal implant to be used as medical and / or dental implant, which actively facilitates control of hard and / or mineralized tissue adhesion to the implant, such as bone, cartilage or dentin addition to the implant surface.
[0017]A typical implant of the present invention either actively facilitates improved hard and / or mineralized tissue adhesion to the implant, improved bone addition to the implant surface, improved bone remodeling and / or biocompatibility of the implant, or it actively inhibits and / or reduces hard and / or mineralized tissue adhesion to the implant, such as inhibits and / or reduces bone attachment to the implant. The effect of the implant on mineralized and / or hard tissue adhesion being directly attributable to at least part of its surface being coated with a low, or with a high concentration layer of polyunsaturated fatty acids (PUFA).
[0020]The invention consequently relates to a novel and simple surface modification method to chemically bind PUFA molecules to a surface comprising Ti or a titaniumoxide by utilizing UV irradiation. A method is thus presented for manufacturing a metal implant which facilitates improved hard and / or mineralized tissue adhesion, improved bone addition, improved effect on bone remodeling and / or biocompatibility, wherein the implant is coated with PUFA at a specific concentration and irradiated with UV light, before and / or after the coating.

Problems solved by technology

However, it has also been reported that bone response to implant surfaces was dependent on the chemical and physical properties of Ti surfaces, thereby affecting implant success.
Especially plasma spraying has been employed frequently, however with numerous problems, including variation in bond strength between the coating and the metallic substaret, non-uniformity in the layer thickness, and poor adhesion between the coating and the metal surface (Satsangi et al., 2004).
Such binding has often been proposed carried out using for example chemical reactants having two reactive functionalities such as formalin or glutaraldehyde, but the reactive nature of these agents often leads to the biomolecules becoming biologically inactive and / or with enhanced immunoreactivity, which is of course undesirable.
Still, the coatings mentioned above all struggle from several draw-backs, due to unresolved technical difficulties.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

example 1

Rough Surface Implant

Matrix:

[0132]

TypeConcentrationof coinof EPATreatmentNo of coinsPolished 0 mMirradiated with UV lightin vitro 6 · 5 = 3010 mMno irradiationchar. 6 · 3 = 1850 mMGrit- 0 mMirradiated with UV lightin vitro 6 · 5 = 30blasted10 mMno irradiationchar. 6 · 3 = 1850 mMTotal number of coins96

Cleaning

[0133]1. Coins rinsed with pure water

2. Coins washed with ethanol

3. Ultrasonication of coins in water for 5 min

4. Again coins rinsed with pure water

5. Coins allowed to dry on sterile bench

6. Autoclaving of coins

Surface Modification

[0134]1. Work in sterile bench

2. EPA solution is filtered (0.2 μm pore size) to sterilise it

3. 10 μl of respective solution of EPA in methanol is given on the surface of the coins

4. Coin is allowed to dry on sterile bench

5. Part of the coins are irradiated with UV light after the solvent evaporated

→Fluo.link, λ=312 nm

→Time of irradiation: 30 min (first test showed that the contact angle is increasing up to

10 min irradiation and decreases subsequently)...

example 2

Smooth Surface Implant

[0136]The aim of this study was to investigate the effect of EPA coating on Ti surface on osteoblast cell response in vitro. Methods to either physically adsorb or chemically bind the layer with EPA were compared, the latter one being produced by UV irradiation of TiO2 surfaces and EPA. Those surface coatings were detected and characterized by physical and chemical analytical methods. In vitro experiments were carried out to test cytotoxicity and ability of EPA-modified Ti surfaces to promote cell attachment and osteogenic differentiation of MC3T3-E1 cells.

Materials and Methods

Chemicals

[0137]EPA was purchased from Sigma (St. Louis, Mo., USA), radioactive labelled [14C]-EPA was obtained from American Radiolabeled Chemicals, Inc. (St. Louis, Mo., USA).

Titanium Implants and Treatments

[0138]Cp Ti implants with a diameter of 6.25 mm and a height of 2 mm were machined from cp Ti rods and subsequently grinded and polished (Phoenix 4000, Buehler GmbH, Düsseldorf, Germa...

example 3

[0176]Experiments performed in vivo with titanium implants containing a high dosage of physical adsorbed EPA and a low dosage of chemically-bound EPA.

Materials and Methods

Titanium Coins

[0177]Commercially pure (cp) machined titanium implants with a diameter of 6.25 mm and a height of 1.95 mm were cleaned and sterilized before use. Briefly, implants were washed together in a glass beaker with deionised water for 30 s, then with 70% ethanol for 30 s, and then with ultrasonic bath at 40° C. for 5 min in deionised water. The implants were subsequently placed in 40% NaOH solution in a water bath of 40° C. for 10 min, sonicated in deionised water for 5 min, and then washed with deionised water until the pH reached 6. Afterwards the implants were sonicated in deionised water at 50° C. for 5 min, placed in 50% HNO3 solution at 50° C. for 10 min, and sonicated in deionised water for another 5 min. The implants were washed with deionised water until reached pH=6 and were stored in 70% ethanol....

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Abstract

A medical or dental implant which contains a metal material selected from the group consisting of titanium or an alloy thereof, wherein at least part of the surface of the metal material is coated with a layer of a polyunsaturated fatty acids (PUFA). In a preferred embodiment, the implant has been exposed to UV radiation for at least 30 seconds before, simultaneously with and / or after the coating with PUFA. Depending on the concentration of polyunsaturated fatty acids on the surface, at least parts of the implant exhibits improved effect on adhesion of mineralized and / or hard tissue, such as on bone remodeling and / or improved biocompatibility, or alternatively inhibits adhesion of mineralized and / or hard tissue to the implant. The metal material is preferably titanium, the polyunsaturated fatty acid is preferably EPA.

Description

FIELD OF THE INVENTION[0001]The present invention relates to a metal implant to be used as medical and / or dental implant, which actively facilitates controlled adhesion of hard and / or mineralized tissue to the implant, e.g. which actively induces adhesion of hard and / or mineralized tissue to the implant and / or exhibits improved effect on bone remodeling and / or biocompatibility of the implant due to at least part of its surface being coated with a low concentration layer of polyunsaturated fatty acids (PUFA). The present invention at the same time relates to a metal implant to be used as medical and / or dental implant, which actively inhibits hard and / or mineralized tissue adhesion to the implant, such as bone attachment, due to at least part of its surface being coated with a layer of polyunsaturated fatty acids (PUFA) in a high concentration. The invention further relates to a method for manufacturing said metal implant with either inducing or inhibiting effect on hard and / or minera...

Claims

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Application Information

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IPC IPC(8): A61F2/28A61L33/06
CPCA61L27/06A61L27/28A61L27/50A61L2430/02A61L31/08A61L31/14A61L31/022A61L27/54A61L31/16A61K31/593A61L2300/412A61L2300/428A61P19/08
Inventor LYNGSTADAAS, STALE PETTERMONJO, MARTAPETZOLD, CHRISTIANEELLINGSEN, JAN ERIK
Owner NUMAT BIOMEDICAL
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