Coriolus versicolor extracts, methods of isolating biologically-active compounds, and uses thereof

a technology of biologically active compounds and extracts, which is applied in the separation/purification of carboxylic acid esters, fatty-oils/fats, drug compositions, etc., can solve the problem of limited knowledge of the precise mechanism by which it exerts its pharmacological action, and achieve the effect of reducing or ameliorating the metastasis or invasiveness of tumors
US20130274333A1Inactive Publication Date: 2013-10-17PURAPHARM +1
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Patent Information

Authority / Receiving Office
US · United States
Current Assignee / Owner
PURAPHARM
Publication Date
2013-10-17
Estimated Expiration
Not applicable · inactive patent

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Abstract

The subject invention provides efficient and convenient methods of isolating 9-oxo-10E, 12E-octadecadienoic acid methyl ester (9-KODE methyl ester) from C. versicolor. In addition, the subject invention provides therapeutic uses of Coriolus versicolor extracts, biologically-active chemical substituents isolated from C. versicolor, as well as 9-KODE methyl ester and related compounds. In a preferred embodiment, the subject invention can be used to inhibit the metastatic spread of cancer cells.
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Description

[0001] This application claims the benefit of U.S. provisional application Ser. No. 61 / 622,846; filed Apr. 11, 2012, which is incorporated herein by reference in its entirety.BACKGROUND OF THE INVENTION

[0002] Coriolus versicolor, also known as Agaricus versicolor, Boletus versicolor, Polyporus versicolor, Polystictus versicolor, Poria versicolor, Trametes versicolor, Yun-Zhi (Chinese), Kawaratake (Japanese), and “turkey tail” (North America), belongs to the Basidiomycetes class and Polyporaceae family. It is widely distributed throughout the world, where more than 120 different strains have been identified in the wooded temperate zones of Asia, Europe, and North America.

[0003] The medicinal value of C. versicolor was first recorded in Compendium of Materia Medica (Compendium Medica) by Li Shi Zhen during the Ming Dynasty (1368-1644AD) in China. According to Compendium Medica, C. versicolor (Yun-Zhi), if consumed regularly, can invigorate vital energy, maintain one's optimal weight, pro...

Claims

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