Tissue scaffolds for electrically excitable cells

a tissue scaffold and excitable cell technology, applied in the field of tissue scaffolds, can solve the problems of limited predictive power of human clinical trials and post-market surveillance of preclinical data acquired through the use of rodent brain slices, high animal care and labor-intensive use costs, etc., and achieves improved predictive power, reduced cost, and the effect of improving the quality of li
US20160251646A1Inactive Publication Date: 2016-09-01INNOVATIVE SURFACE TECHNOLOGIES LLC
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Patent Information

Authority / Receiving Office
US · United States
Current Assignee / Owner
INNOVATIVE SURFACE TECHNOLOGIES LLC
Publication Date
2016-09-01
Estimated Expiration
Not applicable · inactive patent

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Abstract

Inventive concepts relate generally to nanofibrous scaffolds useful for electrophysiological assays. Scaffolds include polymeric nanofibrous components and electrically excitable cells immobilized at a distinct cell seeding domains on the scaffold. Methods and kits including the scaffolds are also described.
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Description

CROSS REFERENCE TO RELATED APPLICATIONS

[0001] This application claims benefit under 35 U.S.C. §119(e) to U.S. Patent Application Ser. No. 61 / 890,193, entitled “CELL GROWTH SUBSTRATES CONTAINING OPEN FIELD ARCHITECTURES,” filed Oct. 12, 2013, the contents of which are incorporated herein in their entirety for all purposes.FIELD OF THE INVENTION

[0002] Inventive concepts relate generally to the field of drug discovery and drug development for the screening of disease treatment.BACKGROUND

[0003] The global drug discovery technologies market is projected to reach $19.9 Billion by 2017. In the primary methodology, High Throughput drug Screening process (HTS), massive libraries of chemical entities are evaluated for activity towards a target of interest, often expressed in a suitable cell line.

[0004] This identification process is then followed by hit confirmation, hit expansion, and lead optimization for drug candidates. Additionally, high-content screening utilizing fluorescence, morphologica...

Claims

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