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The calcium-sensing receptor (CaSR) is a Class C G-protein coupled receptor which senses extracellular levels of calcium ion. It is primarily expressed in the parathyroid gland and the renal tubules of the kidney. In the parathyroid gland, the calcium-sensing receptor controls calcium homeostasis by regulating the release of parathyroid hormone (PTH). In the kidney it has an inhibitory effect on the reabsorption of calcium, potassium, sodium, and water depending on which segment of the tubule is being activated.
A chicken bone collagen polypeptide that promotes calcium absorption, its chelate, preparation method and application
This invention belongs to the field of functional foods and bioactive peptides, specifically relating to a chicken bone collagen peptide that promotes calcium absorption, its chelate, preparation method, and application. This invention employs a rational molecular docking screening strategy, directly screening for the high-affinity peptide DFSLPQPPQ from a chicken bone collagen peptide library by simulating the interaction between peptides and calcium-sensitive receptors. This overcomes the inefficiency of traditional "blind screening" methods, achieving targeted peptide discovery based on mechanisms. The prepared peptide-calcium chelate (DFSFLPQPPQ-Ca) exhibits excellent calcium absorption-promoting performance in the Caco-2 cell model. This invention utilizes chicken bone by-products as raw materials, achieving high-value utilization of resources and providing a precise development path for poultry processing by-products based on clearly defined bioactive peptides, possessing significant industrial promotion value and economic benefits.
Owner:衢州市浙工大生态工业创新研究院