8 results about "Calcium-sensing receptor" patented technology

The invention belongs to the technical field of biology, and particularly relates to a calcium-sensitive receptor nano antibody with a positive allosteric regulation effect and application of the calcium-sensitive receptor nano antibody. The nano antibody can specifically recognize and bind CaSR, has good affinity with CaSR, can be used as a positive allosteric modulator of CaSR, and can be used for preparing products for diagnosing, preventing and / or treating CaSR related diseases or detecting the existence or level of CaSR in a sample.

The invention discloses an application of cyclic dipeptide in preparation of drugs for treating diseases related to damage of calcium-sensitive receptors, the dipeptide can directly activate CaSR activity of damaged organ cells in a targeted manner, and can enter the cells to promote expression of CaSR upstream genes, so that the related diseases caused by damage of CaSR are effectively reversed. Animal experiments prove that Cyclo (L-Pro-L-Trp) can effectively improve the symptoms of hypocalcemia, intestinal tract calcium absorption damage, parathyroid hormone excessive secretion, osteoporosis and the like caused by CaSR damage, and non-target organ toxicity is controllable (liver and kidney function indexes are not obviously changed). Cell experiments prove that Cyclo (L-Pro-L-Trp) can effectively activate CaSR of parathyroid gland main cells and intestinal epithelial cells and various calcium ion internal flow channels and promote proliferation of the parathyroid gland main cells and the intestinal epithelial cells.

This invention belongs to the field of functional foods and bioactive peptides, specifically relating to a chicken bone collagen peptide that promotes calcium absorption, its chelate, preparation method, and application. This invention employs a rational molecular docking screening strategy, directly screening for the high-affinity peptide DFSLPQPPQ from a chicken bone collagen peptide library by simulating the interaction between peptides and calcium-sensitive receptors. This overcomes the inefficiency of traditional "blind screening" methods, achieving targeted peptide discovery based on mechanisms. The prepared peptide-calcium chelate (DFSFLPQPPQ-Ca) exhibits excellent calcium absorption-promoting performance in the Caco-2 cell model. This invention utilizes chicken bone by-products as raw materials, achieving high-value utilization of resources and providing a precise development path for poultry processing by-products based on clearly defined bioactive peptides, possessing significant industrial promotion value and economic benefits.

The invention belongs to the technical field of chemical raw material medicines, and particularly relates to an aryl alkyl amine compound as well as a preparation method and application thereof. The structure of the aryl alkyl amine compound is shown as a formula I. Experiments prove that the allosteric agonist effect of the compound provided by the invention on a calcium-sensitive receptor is superior to or equivalent to that of Evocalpet, and the aryl alkyl amine compound has potential in preparation of drugs for treating secondary hyperparathyroidism. Formula I

The invention belongs to the technical field of vinasse functional development, and particularly relates to yellow wine vinasse polypeptide with Kokumi flavor enhancement and health promotion functions as well as a preparation method and application. The yellow wine vinasse polypeptide provided by the invention is prepared by the following steps: firstly, identifying three active peptides RFY, QMGR and AGRR which have strong binding capacity with a calcium sensitive receptor (CaSR) and glucolipid metabolism related enzymes from yellow wine vinasse by using high-throughput screening and molecular docking technologies, and synthesizing the three polypeptides through chemical synthesis methods such as a solid-phase synthesis method or a bioengineering method after obtaining amino acid sequences RFY, QMGR and AGRR. Sensory evaluation, an electronic tongue test and an in-vitro / in-vivo glycolipid metabolism related enzyme inhibition and oxidation resistance test are carried out, so that the three polypeptides are proved to be the multi-effect yellow wine vinasse polypeptides with Kokumi flavor enhancement and health promotion, and the technical problem of lack of the multi-effect yellow wine vinasse polypeptides in the prior art is solved.

Disclosed herein are therapies for the treatment of ocular disorders, such as dry eye, by targeting calcium-sensitive receptors (CaSR) that are modulators of ocular surface ion transport.

The present invention relates to labeled compounds suitable for positron emission tomography (PET) imaging and / or fluorescence imaging such as near-infrared fluorescence imaging (NIRF). The invention further relates to the use of these compounds for carrying out PET scans, imaging calcium sensing receptor (CSR)-positive organs, excising parathyroid tissue, protecting parathyroid tissue during thyroid surgery, and treating disorder(s) of a CSR- positive tissue in a subject.

The invention discloses a composition for promoting secretion of growth factors and proliferation of bone cells and a preparation method of the composition, and belongs to the technical field of biological medicines and functional foods. Each unit dose of the combination group comprises 300 to 500 mg of calcium salt, 30 to 50 mg of magnesium salt, 2 to 5 mg of zinc salt, 250 to 350 mg of bovine bone protein peptide, 40 to 60 mg of hydrolyzed yolk powder, 8 to 15 [mu] g of vitamin D3, 5 to 20 [mu] g of vitamin K2 and 200 to 300 mg of an amino acid compound. Through cooperation of calcium, magnesium and zinc with bone-derived peptide and vitamin D / K2, calcium-sensitive receptor (CaSR) and BMP / Smad signaling pathways are activated, osteoblast proliferation rate and endogenous growth factor (BMP-2 and IGF-1) secretion amount are remarkably increased, and the bone-derived peptide composition is used for promoting height increase of children or teenagers, preventing or treating osteoporosis of various people, assisting fracture repair and bone regeneration, and has a good application prospect. The method has the advantages of high-efficiency collaboration, safety and controllability.