The invention discloses a hardware simulation device. The device comprises a power supply module, a communication module and a plug-in module. The power supply module is used for supplying power to a simulated chip and a peripheral device, the communication module is used for being connected and communicated with a computer, and the plug-in module is used for being connected with the power supply module and the communication module and is further connected with externally-arranged hardware. The hardware simulation equipment for conducting general, immediate and low-speed simulation on embedded type processing cores, such as a microcontroller, a microprocessor and a DSP is designed, and the device is applied to the embedded type system teaching and research and development field. A complete program file does not need to be modified and compiled, time is saved, errors can be rapidly found, the system problem is solved, the correctness of the working process and the hardware design is determined, the cost of hardware in loop simulation equipment is reduced, and varieties of supported chips are more.