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Step-degrdeable bioactive implanting material comprising growth promotion factor

A growth-promoting factor and biologically active technology, applied in the field of degradable implant materials, can solve problems such as difficult bonding, lack of biological activity, and inability to be used in clinical practice, and achieve the effect of accelerating growth and promoting proliferation and differentiation

Inactive Publication Date: 2008-04-16
SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, after this type of composite material is implanted in the body, due to the rapid degradation rate of the scaffold, the growth factor is released rapidly in the early stage, and it is difficult to maintain the effective concentration of growth-promoting factor in the implanted part for a long time, which in turn affects its bone-inducing effect. or bone growth-promoting properties
In addition, the rapid degradation rate of the degradable scaffold does not match the growth rate of new bone, and it cannot provide relatively stable mechanical support for the formation or growth of new bone for a long time.
In addition, this type of material lacks biological activity, and it is difficult to produce a biological bond with the biological autologous bone after implantation, which also seriously affects its clinical application effect, or even cannot be used in clinical practice.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Dissolve 5g of chitosan powder in 2wt% acetic acid solution, stir rapidly for 3 hours to prepare a 3wt% chitosan transparent solution, then add 300mg icariin therein, and continue stirring for 30min to fully dissolve it. Add 45ml of 10wt% NaOH solution to the mixture, continue to stir and react for 1 hour, then filter the precipitate, wash it with distilled water for 5 times, dry it under vacuum at 40°C, and grind it into a 120-mesh powder.

[0026] Add 5g of polyvinyl alcohol into 100ml of deionized water, stir at a constant temperature of 90°C for 5 hours to make it dissolve completely, add 150g of 4wt% nano-hydroxyapatite slurry (can be replaced by nano-carbonate-containing apatite slurry or nanometer fluorine-containing apatite slurry), after fully stirring and mixing, chitosan powder containing icariin was added therein, and stirring was continued for 30 minutes. Then, a bioactive implant material with three-dimensional penetrating pores with a pore size ranging fr...

Embodiment 2

[0028] Dissolve 5 g of glucosidan in deionized water to form a 5 wt % transparent sol, then add 300 mg of icariin therein, and continue stirring for 30 min to fully dissolve it. Afterwards, the mixed solution was poured into ethanol for precipitation, and the precipitate was filtered and baked at 50° C. for 6 hours to fully volatilize and dry the ethanol, and ground into a 120-mesh powder.

[0029] Add 5g of polyvinyl alcohol into 100ml of deionized water, stir at a constant temperature of 90°C for 5 hours to make it dissolve completely, and add 150g of 4wt% nano-hydroxyapatite slurry (can also be replaced by nano-carbonate-containing apatite slurry) or nano fluorine-containing apatite slurry), after fully stirring and mixing, add icariin-containing glucosidan powder into it, and continue stirring for 30 minutes. Then, a bioactive implant material with three-dimensional penetrating pores with a pore size ranging from ≤10 μm to 300 μm and rich in micropores on the macropore wal...

Embodiment 3

[0031] 5 g of sodium alginate was dissolved in deionized water to prepare a 5 wt % transparent solution, and then 100 mg of ground beetle extract was added thereto, and stirring was continued for 30 min to fully dissolve it. Afterwards, the mixed solution was poured into ethanol for precipitation, and the precipitate was filtered and baked at 50° C. for 6 hours to fully volatilize and dry the ethanol, and ground into a 120-mesh powder.

[0032] Add 5g of polyvinyl alcohol into 100ml of deionized water, stir at a constant temperature of 90°C for 5 hours to make it dissolve completely, and add 150g of 4wt% nano-hydroxyapatite slurry (which can be nano-carbonate-containing apatite slurry or nano Fluorine-containing apatite slurry), after fully stirring and mixing, the glucosidan powder containing the wood beetle extract was added therein, and the stirring was continued for 30 minutes. Then, a bioactive implant material with three-dimensional penetrating pores with a pore size ran...

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Abstract

The present invention relates to a bioactive implant material which can be stepwise degraded and contains somatomedin. It is basically formed from medical quick degradable high-molecular component containing somatomedin and medical slow degradable high-molecular component containing biomimetic apatite by means of blending or copolymerization mode, in which the medical quick degradable high-molecular component containing somatomedin can be quickly degraded and can release somatomedin in the implanted initial stage, and the medical slow degradable high-molecular component containing biomimetic apatite can provide relative stable active scaffold for new bone formation and growth, and can be slowly degraded after the new bone is formed and matured.

Description

technical field [0001] The invention relates to a degradable implant material used as a carrier bracket for bone defect repair. Background technique [0002] The use of materials composited with degradable carrier scaffolds and growth factors for defect repair is currently a hot spot in the research of medical implant materials. Among them, the degradable characteristics of the carrier scaffold are used to slowly release the growth factor in the body to achieve a high local concentration, so as to promote the differentiation and proliferation of osteoblasts, or promote the mitosis of cells and induce osteogenesis, thereby accelerating defect healing and improving implantation. Success rate. The degradable scaffold, as a slow-release carrier of growth factors, can provide mechanical support for cell attachment and growth at the initial stage of implantation, and then slowly degrades to provide space for the growth of new tissues. After the defect is healed, the scaffold is a...

Claims

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Application Information

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IPC IPC(8): A61L31/00A61L27/00
Inventor 李玉宝张利
Owner SICHUAN UNIV
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