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Degradable and absorbable polymer nano fibrous membrane materials and preparation process and use thereof

A nanofiber membrane and biodegradation technology, which is applied in the field of polymer nanofiber membrane materials and their preparation, can solve problems such as being unsuitable for electrospinning, and achieve the effects of good uniformity, high porosity, and broad application prospects

Inactive Publication Date: 2010-01-06
INST OF CHEM CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although gelatin can be electrospun in 2,2,2-trifluoroethanol solution (Polymer, 2004, 45:5361-5368), the aqueous solution of gelatin is considered unsuitable for electrospinning (Polymer, 2004, 45 : 5361~5368; J Biol Chem, 1934, 107: 629~634)

Method used

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  • Degradable and absorbable polymer nano fibrous membrane materials and preparation process and use thereof
  • Degradable and absorbable polymer nano fibrous membrane materials and preparation process and use thereof
  • Degradable and absorbable polymer nano fibrous membrane materials and preparation process and use thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0059] 1) Prepare 5ml of HA / GE water / ethanol solution with a mass volume percentage concentration of 1.8wt / v, wherein the mass ratio of HA / GE is 5:1, and the volume ratio of water / ethanol is 90:10, and put it in the stock solution device.

[0060] 2) Install a metal plate as a collector, and the temperature of the collector is 40 degrees.

[0061] 3) Adjust the distance between the spinneret and the collecting plate to be 8cm.

[0062] 4) The ambient temperature of spinning is 50 degrees, including the temperature of the solution in the liquid storage device and the temperature of the collecting plate are both 50 degrees.

[0063] 5) Turn on the high-voltage power supply, adjust the voltage to 18KV, and the air velocity of the environment is 6m 3 / hr, the feed rate of the solution is 100ul / min, spinning, and then the polymer fiber film on the receiving plate is vacuum-dried at 40 degrees for 2 days.

[0064] 6) Place the vacuum-dried polymer fiber membrane in 20 ml of a mix...

Embodiment 2

[0066] 1) Prepare 10ml of water / ethanol solution of HA / GE with a mass volume percentage concentration of 2wt / v, wherein the mass ratio of HA / GE is 3:1, the volume ratio of water / ethanol is 90:10, and the polymer solution contains 0.02 g of growth factor, polymer solution was placed in the reservoir.

[0067] 2) Install a metal plate as a collector.

[0068] 3) Adjust the distance between the spinneret and the collecting plate to be 8cm.

[0069] 4) The ambient temperature of spinning is 50 degrees, including the temperature of the solution in the liquid storage device and the temperature of the collecting plate are both 50 degrees.

[0070] 5) Turn on the high-voltage power supply, adjust the voltage to 18KV, and the air velocity of the environment is 5m 3 / hr, the moving speed of the spinneret is 0.1m / min, the feeding speed of the solution is 120ul / min, spinning, the moving speed of the collecting plate is 0.01m / min, and then the polymer fiber film on the receiving plate is...

Embodiment 3

[0073]1) Prepare 5ml of HA / GE water / ethanol solution with a mass volume percentage concentration of 3wt / v, wherein the mass ratio of HA / GE is 1:1, and the volume ratio of water / ethanol is 90:10, and place it in the liquid storage device middle.

[0074] 2) Install a metal drum as a collector.

[0075] 3) Adjust the distance between the spinneret and the collector to be 8cm.

[0076] 4) The ambient temperature of spinning is 50 degrees, including the temperature of the solution in the liquid storage device and the temperature of the collecting plate are both 50 degrees.

[0077] 5) Turn on the high-voltage power supply, adjust the voltage to 18KV, and the air velocity of the environment is 4m 3 / hr, the feeding speed of the solution is 130ul / min, the moving speed of the spinneret is 0.5m / min, the rotating speed of the collector is 300r / min, spinning, and then the polymer fiber film on the receiving drum is at 40 Dry under vacuum for 2 days.

[0078] 6) Place the vacuum-drie...

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Abstract

The invention discloses a biological decomposable polymer nanometer fiber film material and preparing method and usage, which is characterized by the following: the material is made of several nanometer to several hundred nanometer fiber diameter nonwoven material, wherein the hyaluronic acid is more than 0 less than or equal to 100; other macromolecular material quantiy is more than 0 less than 100; the quantity of remedy medicine is 0-10 part. The invention possesses well biological compatity, biological decomposition and absorption property, which is applied in the medical tissue engineering rack material.

Description

technical field [0001] The invention belongs to the field of biodegradable and bioabsorbable polymer nanofiber membranes, in particular to a biodegradable and bioabsorbable polymer nanofiber membrane material and its preparation method and medical application. Background technique [0002] Electrospinning is a polymer jet electrostatic stretching spinning method, which is a commonly used technology for preparing polymer ultrafine fibers. This method is obviously different from the traditional spinning method. First, the polymer fluid (such as a charged polymer sub-concentrated solution or a charged polymer melt) is charged with thousands to tens of thousands of volts of high-voltage static electricity, and the charged polymer droplets are Under the action of the electric field force, the apex of the capillary cone is accelerated. When the electric field is strong enough, the polymer droplets can overcome the surface tension and form a jet stream, which falls on the grounded ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08L5/08D01D5/00A61L15/28A61L31/04
Inventor 韩志超贺爱华李军星
Owner INST OF CHEM CHINESE ACAD OF SCI
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