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Finger nail coating agent of antifungal agent and its preparing method

A technology of film coating agent and antifungal drug, applied in the field of antifungal nail coating agent, can solve the problems of affecting appearance, easy recurrence, unsightly nails, etc., and achieves the effects of convenient drug use, simple preparation process and easy cleaning.

Active Publication Date: 2010-12-08
CHONGQING HUAPONT PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] In the prior art, the external medicines for the treatment of onychomycosis are mostly dosage forms such as cream, ointment, cream, liniment, tincture, emulsion, etc. There are two disadvantages in these dosage forms: one is that the medicine is easy to fall off after coating, making the medicine The adhesion time on the nail surface is short, and the drug cannot directly reach the lesion, so the curative effect is not ideal, and it is easy to relapse; second, it affects the appearance, the nail is ugly after application, and the user's acceptance is poor.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] Formula (based on 1000g):

[0034] Naftifine 10g

[0035] Ketoconazole 2.5g

[0036] Propylene glycol 100g

[0037] Acetone 200g

[0038] Ethanol 500g

[0039] Azone 5g

[0040] Polyvinyl alcohol 100g

[0041] Urea 50g

[0042] Vitamin E 5g

[0043] Add water to 1000g

[0044] Made into 1000g

[0045] Preparation Process:

[0046] 1. Weigh 10g of naftifine, 2.5g of ketoconazole and 5g of vitamin E into 100g of propylene glycol, heat up to 60°C, stir and dissolve completely, and obtain the main drug solution;

[0047] 2. Weigh 100g of polyvinyl alcohol, 5g of azone, and 50g of urea and dissolve them in a mixed solvent of 200g of acetone and 500g of ethanol to obtain a matrix solution;

[0048] 3. Add the cooled main drug solution into the matrix solution and mix well under stirring, add distilled water to 1000g;

[0049] 4. Subpackage after testing.

Embodiment 2

[0051] Formula (based on 1000g):

[0052] Naftifine 10g

[0053] Miconazole 2.5g

[0054] Propylene glycol 100g

[0055] Dichloromethane 100g

[0056] Ethanol 600g

[0057] Azone 5g

[0058] Acrylic resin (trade name: Eudragit E100) 200g

[0059] Urea 50g

[0060] Tert-Butyl p-Hydroxyanisole (BHA) 0.2g

[0061]Add water to 1000g

[0062] Preparation Process:

[0063] 1. Weigh 10g of naftifine, 2.5g of miconazole and 0.2g of BHA into 100g of propylene glycol, heat up to 60°C, stir and dissolve completely, and obtain the main drug solution;

[0064] 2. Weigh 200g of Eudragit E100, 5g of azone, and 50g of urea and dissolve them in a mixed solvent of 100g of dichloromethane and 600g of ethanol to obtain a matrix solution;

[0065] All the other preparation steps are the same as in Example 1.

Embodiment 3

[0067] Formula (based on 1000g)

[0068] Butenafine 10g

[0069] Ketoconazole 5g

[0070] Propylene glycol 80g

[0071] Ethyl acetate 100g

[0072] Ethanol 500g

[0073] Dimethylsulfoxide 2g

[0074] Polyvinyl alcohol 150g

[0075] Urea 45g

[0076] Vitamin C 7g

[0077] Add water to 1000g

[0078] Preparation Process:

[0079] 1. Weigh 10g of terbinafine, 5g of ketoconazole and 7g of vitamin C into 100g of propylene glycol, heat up to 60°C, stir and dissolve completely, and obtain the main drug solution;

[0080] 2. Weigh 150g polyvinyl alcohol, 2g dimethyl sulfoxide, and 45g urea and dissolve them in a mixed solvent of 100g ethyl acetate and 500g ethanol to obtain a matrix solution

[0081] All the other preparation steps are the same as in Example 1.

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PUM

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Abstract

An antifungal filming agent for finger nail contains antifungal imidazole medicine, antifungal acrylamine medicine, and a filing material chosen from PVC, ethylcellulose, carfopol resin, chitosan, acryl resin and polylactic acid. Its preparing process is also disclosed.

Description

Technical field: [0001] The invention relates to an antifungal nail coating agent, in particular to a coating agent containing film-forming materials, imidazoles and allylamine antifungal drugs. The invention also relates to a preparation method of the antifungal nail coating agent. Background technique: [0002] Onychomycosis has another name called onychomycosis, is the fungal infection of the nail plate and subungual tissue that is caused by dermatophyte, yeast and fungus, is a kind of common disease, frequently-occurring disease. After being ill, the diseased nail becomes thicker, turbid, gray and faded, and powdery desquamation can be seen at the nail end. The nail plate is often separated from the nail bed, which not only hinders the appearance, but also can be transmitted to each other if disinfection is not taken care of. [0003] Imidazole and allylamine antifungal drugs are new, efficient, safe and low-toxic antifungal drugs commonly used in recent years. It is k...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/70A61K45/06A61K31/4164A61P31/10A61P17/00
Inventor 刘均胜张壹饶中树李娟
Owner CHONGQING HUAPONT PHARMA