Animal stomach extract and use thereof as medicament for treating gastropathy

An extract, animal technology, applied in the direction of drug combination, medical preparations containing active ingredients, pharmaceutical formulations, etc., can solve the difficult problems of the attending doctor, and achieve the effect of eliminating chronic toxicity, promoting mucosal tissue regeneration, and better curative effect.

Inactive Publication Date: 2007-08-08
何执中
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there are many patients with coexistence of chronic gastritis and peptic ulcer clinically, which makes it difficult for the attending doctor.

Method used

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  • Animal stomach extract and use thereof as medicament for treating gastropathy

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Example 1 Preparation of "Weiwei" by adding pig pancreas to pig stomach mucosa as raw material

[0025] Take 1 kg of porcine gastric mucosa and 2 kg of porcine pancreas, and mince them separately as raw materials. 2 liters of water was added to the container, and the raw materials were added twice during stirring to make a homogenate. The pH was adjusted to 4 with salt and hydrochloric acid, and the mixture was stirred and extracted for 5 hours at a temperature of 35°C. Then adjust the pH of the feed liquid to 6-7 with caustic soda, and use a cold water bath to cool down to about 10°C under stirring. The filter residue was removed by filtration with a filter cloth, and the obtained 3 liters of filtrate was concentrated to 1.8 liters at 30° C. with a membrane concentrator. It was placed on a plate and lyophilized by a freeze dryer for 22 hours. The obtained solid was crushed and sieved to obtain 108 g of "Weiwei" powder (sample A).

example 2

[0026] Example 2 Preparation of "Weiwei" using pig stomach as raw material

[0027] Take 1 kg of piglet stomach, mince it, add 0.6 liter of water, a little salt and acetic acid to the reactor, adjust the slurry to pH 3.5, stir and extract at 38 ° C for 4 hours, adjust the feed liquid to pH 6-7 with alkali . Continue stirring and then use ice bath or water bath to cool down to 12°C. Centrifugal filtration to obtain 1.1 liter of filtrate; add 4 liters of edible alcohol to the filtrate under stirring, let it stand, and collect the precipitate by centrifugation after layering. After dehydration and pressing, it was transferred to a vacuum drying oven for drying for 10 hours to obtain a dry solid, which was pulverized and sieved to obtain 28 g of "Weiwei" off-white powder (sample B).

[0028] The above "Weiwei" sample A and sample B were qualitatively detected by ultraviolet light scanning, and the resulting spectrum was shown in the accompanying drawing. It can be seen in the f...

Embodiment 3

[0031] Example 3: The therapeutic effect test of "Weiwei" on reserpine-type gastric ulcer in mice

[0032] 60 mice were divided into the following four groups, 10 mice in each group from ① to ③, and 30 mice in group ④, which were divided into three groups with 10 mice in each group. Among them, each mouse in each group of ②~④ was administered with reserpine (at a dose of 10 mg / kg) to model gastric ulcer caused by gastric injury.

[0033] ①Blank group (10 mice): gavage with equal volume of distilled water.

[0034] ②Control group (10 mice): gavage with equal volume of distilled water.

[0035] ③ Ranitidine group (10 mice): Ranitidine 20mg / kg was given by gavage.

[0036] ④ "Weiwei" group (30 mice): Each group of 10 mice was given different doses of "Weiwei" sample A at 0.3, 0.1, and 0.03 g / kg.

[0037] One hour after the administration, the mice were sacrificed, and the stomach was removed and fixed by injecting 2 mL of 1% formaldehyde.

[0038] The gastric mucosal injury i...

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PUM

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Abstract

The invention relates to a stomach extractive of mammal, which uses the stomach or mucosa of single-stomach mammal as material, to be broken and added with pure water or physiological saline, added with acid material and conservative to adjust the Ph value to 2-5, to be mixed at 20-50Deg. C for 2-6h, and added with edible alkali material to adjust the pH value to 6-7, to be mixed and cooled to 8-12Deg. C, to be filtered to obtain the filter liquor; then depressurizes and concentrates the filter liquor, puts the concentrates material into refrigerator drier, to obtain solid after 20-36h; breaks and screens into powder. The inventive extractive contains variable biological active components, with better biocompatibility with stomach of human body, to adjust the stomach function and treat stomach diseases.

Description

technical field [0001] The present invention relates to a gastric extract of mammals, especially a gastric extract of monogastric mammals (ie, excluding mammals containing multiple stomachs), and the use of the extract as a medicine for treating gastric diseases. Background technique [0002] About 200 million people in my country suffer from chronic gastric diseases, and there are no less than dozens of commonly used Chinese and Western gastric medicines. Many "old stomach diseases" have taken countless medicines for decades and still keep getting sick. The reason is that this kind of "stomach disease" and "stomach medicine" have been interdependent for a long time, and the embarrassing situation of "peaceful coexistence" is caused by the "symptoms but not the disease" of many stomach medicines, and "treating the symptoms but not the root cause". And the recurrence rate after treatment is high, and the resurgence is very fast. There are even clinical case reports of relap...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K35/38A61P1/04
Inventor 何执中何晓瑾唐宁
Owner 何执中
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