Method of producing hepatic targeting drug microcapsule

Abstract

The invention discloses a method for preparing a medicine with liver target taxis for slow-releasing the nanometer microcapsule. The method comprises the following steps: proceeding with enzymatic reaction of liver target taxis gene with sugar monomer of cerebrose residue and ethylated carboxylate; copolymerizing vinyl ester with glycosyl and unsaturated cationic or anion; getting liver target taxis polyelectrolyte; getting the medicinal microcapsule with liver target taxis by multilayer packaging polyelectrolyte on the surface of medicine by electrostatic action, wherein the deactivation speed of microcapsule medicine can be controlled. The polymerization method is simple, high effective and non-toxicity. The coating method has the high efficient, the simple operation and the mild technology, which can cycle several times. The preparing medicine can save for a long time, which can release step by step, can accumulate in the liver, improves the medicinal effect of disease portion, reduces the toxic effect of the other healthy organ, and has the good application prospect.

Description

technical field [0001] The invention relates to a preparation method of drug microcapsules. technical background [0002] Drugs in conventional dosage forms are distributed throughout the body after intravenous, oral or local injection, and the amount of drugs that actually reach the treatment target area is only a small part of the dose, and the distribution of most drugs in non-target areas not only has no therapeutic effect, It can also cause toxic side effects. In response to the above problems, a new type of drug dosage form - targeted drug delivery system has been developed, which can concentrate and localize the drug in diseased tissues, organs, cells or cells. Targeted preparations have the advantages of high curative effect, less drug dosage, and less toxic and side effects. An ideal targeted drug delivery system can release the drug in the target organ or the site of action, and at the same time, the systemic uptake is small, so that the curative effect can be im...

AI Technical Summary

Problems solved by technology

However, there is no report on the formation of microcapsules directly assembled layer by layer on the surface of solid drug particles, and the general layer-by-layer assembly microcapsules that have been reported so far are not grafted with targeting groups and do not have tissue (liver) targeting. Toxic and side effects similar to conventional drugs on normal tissues

The reported drug-carrying systems containing targeting groups all directly chemically couple the target group with the drug, or form a simple complex with the drug, such as the Chinese patent applications with publication numbers CN1087093A and CN1733314A, but this Although the technology enables the drug to have a certain degree of targeting, the sustained release of the drug cannot be precisely regulated, and the synthesis method is relatively complicated.

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