Thin-film material for medical purpose

A film material and plastic technology, applied in the field of making blood and blood components, can solve the problems of poor air permeability, low plasticization efficiency, brittleness, etc., and achieve the effects of reducing cost, improving quality and good elasticity

Active Publication Date: 2011-11-16
SHANDONG WEIGAO GROUP MEDICAL POLYMER
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] We also know that at present, the ordinary plastic blood bags used to store platelets in China have the following problems: poor air permeability, platelets need oxygen to breathe and emit carbon dioxide, and the oxygen permeability of ordinary plastic blood bags is far below the standard requirements; Blood bags are plasticized with a large amount of DEHP. The precipitation of DEHP will increase the pH value of the platelet concentrate, resulting in the death of some platelets, which is not conducive to the preservation of platelets; Obviously hard and brittle; it cannot be stored at -80°C
Some people also use tris (2-ethylhexyl) trimellitate (TOTM) as a plasticizer to partially replace phthalates (DEHP) plasticizers, but the plasticizing efficiency of TOTM is low, and the resulting plastic The resulting blood bag is hard, and the bag is prone to rupture when subjected to centrifugation

Method used

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  • Thin-film material for medical purpose

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042] A kind of medical film material, its used plastic main body is polyvinyl chloride (PVC) resin, concrete component and content are (weight part):

[0043] Polyvinyl chloride resin (PVC) 100

[0044]Dihexyl phthalate (DEHP) 20

[0045] Dioctyl adipate (DOA) 10

[0046] Acetyl Citrate 1

[0047] Dioctyl Epoxy Tetrahydrophthalate (EPS) 20

[0048] Epoxidized soybean oil (ESO) 3

[0049] Organic phosphite (602) 0.5

[0050] Ethylene-vinyl acetate copolymer (EVA) 4

[0051] Calcium stearate 0.5

[0052] Benzyl silicone oil 0.2

[0053] Mix the above-mentioned ingredients in proportion, and use the mature PVC plastic processing technology to perform the following steps:

[0054] (1) Kneading The materials of the above proportioning ratio are fully stirred after being pressurized and heated in a stainless steel container, and then discharged;

[0055] (2) Granulation After kneading, extrude and granulate under the set mature process parameters;

[0056] (3) Calenderin...

Embodiment 2

[0059] A kind of medical film material, its used plastic main body is polyvinyl chloride (PVC) resin, concrete component and content are (weight part):

[0060] Polyvinyl chloride resin (PVC) 100

[0061] Dihexyl phthalate (DEHP) 25

[0062] Dioctyl adipate (DOA) 14

[0063] Acetyl Citrate 3

[0064] Dioctyl Epoxy Tetrahydrophthalate (EPS) 2

[0065] Epoxy Linseed Oil (ELO) 8

[0066] Organic phosphite (CH55) 1

[0067] Ethylene-vinyl acetate copolymer (EVA) (or polyurethane) 1

[0068] Calcium Zinc Composite Stabilizer 1

[0069] Benzyl silicone oil 0.5

[0070] In this formula, CH55 is used instead of 602 in the stabilizer system, and the calcium-zinc composite stabilizer is used instead of stearate (calcium stearate, zinc and aluminum). The formula has better safety and higher thermal stability.

[0071] The above-mentioned components of the present invention are mixed, granulated and calendered to form a film material with a thickness of 0.35-0.45 mm. The obtained...

Embodiment 3

[0073] A kind of medical film material, its used plastic main body is polyvinyl chloride (PVC) resin, concrete component and content are (weight part):

[0074] Polyvinyl chloride resin (PVC) 100

[0075] Dihexyl phthalate (DEHP) 22

[0076] Dioctyl adipate (DOA) 18

[0077] Acetyl citrate 5

[0078] Dioctyl Epoxy Tetrahydrophthalate (EPS) 7

[0079] Epoxy Linseed Oil (ELO) 10

[0080] Organic phosphite (CH55) 0.6

[0081] Ethylene-vinyl acetate copolymer (EVA) 5

[0082] Stearate 0.7

[0083] Benzyl silicone oil 0.1

[0084] The raw materials used in this formula are produced according to the normal production steps after being measured, and made into pellets, which are mixed, granulated and calendered to form a film material with a thickness of 0.35-0.45mm. The obtained film material is soft and transparent, has good air permeability, good thermal stability and good low temperature resistance. The film is heat-synthesized into bags of different specifications on a h...

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Abstract

The invention relates to a medical film material. The plastic body of the invention is PVC resin, which is added an appropriate of plasticizer and other additives, wherein, the weight content of all components is: 100 portion of PVC resin, 20 to 25 portion of dihexyl phthalate, 10 to 15 portion of di-n-octyl adipate, 1 to 5 portion of acetyl acid ester, 0 to 20 portion of epozy tetrahydro di-2-ethylhexyl phthalate, 2 to 10 portion of epoxidized soybean oil, 1 to 5 portion of EVA, 0.5 to 1 portion of stearate, 0.1 to 0.5 portion of lubricant polymethylphenyl siloxane fluid. The components are mixed, granulated, compressed and shaped, and made into the film material with thickness of 0.35 to 0.45mm. The invention has the advantages of reasonable prescription, good elasticity, soft and transparent film material, good permeability, good thermal stability and good low temperature resistance. On a high-frequency hot sealing machine, the film is hot sealed into bags in different sizes for storing blood and blood components; in particular the blood platelet storing bags can store the blood platelet for 5 days at normal temperature.

Description

technical field [0001] The present invention relates to a polymer material, in particular to a [0002] Medical film material for storage bags. Background technique [0003] We know that the polyvinyl chloride (PVC) material itself is relatively hard. After adding plasticizers, PVC becomes soft and elastic, easy to shape and process, and can be made into medical products of various shapes. Therefore, it has become a widely used material for making medical products. [0004] We also know that at present, the ordinary plastic blood bags used to store platelets in China have the following problems: poor air permeability, platelets need oxygen to breathe and emit carbon dioxide, and the oxygen permeability of ordinary plastic blood bags is far below the standard requirements; Blood bags are plasticized with a large amount of DEHP. The precipitation of DEHP will increase the pH value of the platelet concentrate, resulting in the death of some platelets, which is not conducive t...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L33/06
Inventor 陈晓通李未扬赵恒坤岳锦花张娥
Owner SHANDONG WEIGAO GROUP MEDICAL POLYMER
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