Process for the preparation of NMDA antagonists

A technology of chitosan and antibacterial agent, which is applied in the field of preparation of antibacterial agent containing natural polymer chitosan-based guanidine salt, can solve the problems of no durability, easy loss of antibacterial activity, small molecular weight, etc., and achieve an environmentally friendly effect

Inactive Publication Date: 2008-04-09
QINGDAO UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Although chitosan or guanidine salts can be used as antibacterial agents, chitosan as an antibacterial agent is greatly affected by molecular weight and use environment. Only in suitable molecular weight and acidic environment has obvious antibacterial activity, thus limiting its purpose
In the existing technology, Chinese patent 2003101055431 discloses a "chitin and biofilm finishing agent for textiles and its preparation and application process". Ammonium salts as antimicrobials
Although guanidinium salts have strong antibacterial activity and are less affected by environmental conditions, they usually have a small molecu

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0014] Prepare 1000mL of 1% acetic acid solution, dissolve 30g of chitosan in it with stirring, heat up to 50°C for 1 hour, then slowly dissolve 70g of chitosan in it, and continue the reaction for 30 minutes to obtain an antibacterial agent containing 7% chitosan.

[0015] Applications of antimicrobial agents containing chitosan:

[0016] Dilute the above-mentioned chitosan antibacterial agent with water 10 times. The textiles are pure cotton towels, blended fabrics or non-woven napkins. The padding process is used for two dipping and two rolling at 30°C to 70°C, and the excess rate is 60% to 200% → drying 85℃~105℃→baking 150℃~190℃→antibacterial products.

[0017] Dilute the chitoguanan antibacterial agent 300 to 500 times with water, and use the spray method for antibacterial and disease prevention of crops, fruits and vegetables.

Embodiment 2

[0019] Prepare 100L of 1.5% acetic acid solution, dissolve 2Kg of chitosan in it with stirring, raise the temperature to 45°C for 2 hours, then slowly dissolve 5.5Kg of chitosan in it, continue the reaction for 1 hour, then add 5% dodecyldimethylbenzyl Hydroxyl ammonium chloride 10Kg stirs, promptly obtains the chitoguanidine antibacterial agent containing chitoguanidine 5%.

[0020] Dilute the above-mentioned chitosan antibacterial agent 10 times with water. The textiles are pure cotton towels, blended fabrics or non-woven napkins. The padding process is used. The second dipping and second rolling are at 30°C to 70°C, and the excess rate is 60% to 200%→drying Drying at 85℃~105℃→baking at 150℃~190℃→antibacterial products.

[0021] Dilute the chitoguanan antibacterial agent 300 to 500 times with water, and use the spray method for antibacterial and disease prevention of crops, fruits and vegetables.

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PUM

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Abstract

The invention provides a preparation method for crustacean guanidine containing antimicrobial. The crustacean guanidine containing antimicrobial is compounded after the reaction of crustacean guanidine, chitosan, and surfactant. The preparation method has the procedure that the chitosan is dissolved in the acid containing water, when the temperature rises to 20-60 DEG C under stirring for 0.5-5 hour reaction, then the crustacean guanidine is added for 0.1-2 hours full reaction, and finally the surfactant evenly added and stired; and then the crustacean guanidine containing antimicrobial is made. The crustacean guanidine containing antimicrobial in the textile has the application that the padding process is used to ensure that the textile possesses antibiotic, moisturizing, and skin protecting functions. The application in the agriculture is realized by diluting the crustacean guanidine containing antimicrobial proportionately into operating liquid of definite consistence, then applying the operating liquid to the crops or fruit trees in the means of spray or irrigation. The crustacean guanidine containing antimicrobial can inhibit the microorganisms, can destroy virus, can preserve moisture, and can increase the yield.

Description

Technical field: [0001] The invention relates to an antibacterial agent prepared from natural products guanidine and chitin as raw materials, in particular to a preparation method of an antibacterial agent containing natural polymer chitosan-based guanidine salt (hereinafter referred to as chitoguanidine). technical background: [0002] Guanidine exists in natural products such as proteins, nucleic acids, streptomycin, and various plants such as sugar beets, rice husks, mushrooms, and beans. Humans and animals also contain trace amounts of guanidine, but free guanidine is very unstable and easily absorbed in the air. of carbon dioxide to generate guanidine carbonate, so guanidine usually exists stably in the form of guanidine salt. Guanidine salt is an important component of guanidine compounds, which can be derived into a wide variety of guanidine derivatives, which have good antibacterial properties. [0003] Chitin is the collective name of chitin and chitosan. Chitosan ...

Claims

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Application Information

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IPC IPC(8): A01N47/44A01P1/00
Inventor 李群
Owner QINGDAO UNIV
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