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Similar bone biology medical material for slow releasing bioactivity factor as well as its preparing method

A technology of biologically active factors and biomedical materials, applied in medical science, prostheses, coatings, etc., can solve problems such as poor effect, long healing period, and limited biological activity, and achieve simple and easy preparation process conditions, speed up Healing process, good effect of biological activity

Inactive Publication Date: 2008-04-09
ZHEJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the temperature of the plasma spraying process reaches more than 1,000 degrees, and it is impossible to introduce bioactive factors with limited stability into the coating.
However, the pure hydroxyapatite coating has limited biological activity and cannot stimulate the proliferation and differentiation of osteoblasts, thereby promoting osteogenesis.
This makes the implant slow to integrate with the bone tissue in the body, resulting in a long healing period and poor results

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Ca(NO 3 ) 2 ·6H 2 O and NH 4 h 2 PO 4 Dissolve in distilled water, and prepare A solution with a calcium concentration of 4.5mM and a phosphorus concentration of 9mM. Dissolve collagen in hydrochloric acid solution and mix it with solution A to form solution B, so that the concentration of collagen in solution B is 0.2 g / L. Add bone morphoprotein-2 to solution B to make the concentration of bone morphoprotein-2 in the solution 0.01 g / L, and adjust the pH value of the solution to 5.0 with ammonia water to serve as an electrolyte solution. The medical titanium alloy implant is used as the cathode, the platinum is the anode, and the saturated calomel electrode is the reference electrode. Immerse in the electrolyte solution. The temperature of the electrolyte solution is 37°C. The working distance between the positive and negative electrodes is 2cm. 15mA, after 1 hour of deposition, the medical metal graft was taken out for cleaning, and after drying, a bone-like bioa...

Embodiment 2

[0024] Ca(NO 3 ) 2 ·6H 2 O and KH 2 PO 4 Dissolve in distilled water, and prepare A solution with a calcium concentration of 42mM and a phosphorus concentration of 25mM. Dissolve the collagen in the acetic acid solution and mix it with the A solution to form the B solution, so that the collagen concentration in the B solution is 0.5 g / L. BMP-4 was added to solution B so that the concentration of BMP-4 in the solution was 0.2 g / L, and the pH value of the solution was adjusted to 3.5 with Tris buffer solution as an electrolyte solution. The medical stainless steel implant is used as the cathode, the platinum is used as the anode, and the silver chloride electrode is used as the reference electrode. Immerse in the electrolyte solution. The temperature of the electrolyte solution is 18°C. The working distance between the positive and negative electrodes is 20cm, and the constant voltage mode is used to maintain the voltage at 30V. , After 0.5h of deposition, the medical stain...

Embodiment 3

[0026] CaCl 2 and NaH 2 PO 4 Dissolve in distilled water, and prepare A solution with calcium concentration of 2mM and phosphorus concentration of 1mM. Dissolve collagen in hydrochloric acid solution and mix it with solution A to form solution B, so that the concentration of collagen in solution B is 5 g / L. Add bone morphoprotein-7 to B solution, so that the concentration of bone morphoprotein-7 in the solution is 5g / L, and adjust the pH value of the solution to 5.0 with ammonia water, as the electrolyte solution. The medical cobalt-chromium-molybdenum alloy implant is used as the cathode, the platinum is used as the anode, and the saturated calomel electrode is used as the reference electrode. The electric current is 10mA, and the medical cobalt-chromium-molybdenum alloy graft is taken out after 24 hours of deposition, cleaned, and dried to obtain a bone-like bioactive coating medical material that can release bioactive factors slowly.

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Abstract

The invention discloses bone-like bio-medical material of a slow-release bioactive factor, the bone-like bio-medical material consists of a medical metal transplant body and the bone-like bioactive coating of the slow-release bioactive factor, and the bone-like bioactive coating is coated on the surface of the medical metal transplant body. The invention adopts an electrolytic deposition method to prepare, electrolyte solution contains calcium, a phosphorous compound, bone matrix collagen and the bioactive factor, the medical metal transplant body is taken as a working electrode, platinum is taken as a reference electrode, through the electrode reaction, the bone-like bioactive coating of the slow-release bioactive factor is deposited on the surface of the medical metal transplant body. Compared with the pure inorganic coating, through the adoption of the invention method, the bioactive coating acquired on the surface of the metal transplant body is similar to a natural bone in the component and the structure, and can control the slow-release bioactive factor, adjust, control and promote the growth of bones. The disadvantages that the biological activity of the business use hydroxyapatite coating is limited, the growth of bones cannot be promoted, the required curing time is long, etc. are solved. The preparation process of the invention is simple, highly effective and easy to be industrialized.

Description

technical field [0001] The invention relates to a bone-like biomedical material capable of slow-releasing bioactive factors used for hard tissue repair or replacement and a preparation method thereof. Background technique [0002] Hydroxyapatite coating has excellent biocompatibility and osteoconductivity. The use of plasma spraying technology to prepare hydroxyapatite coating on the surface of medical metal implants to treat bone diseases and restore the physiological functions of patients has been widely used in clinical practice. For example, the Chinese patent CN1064610 adopts a plasma spraying process to prepare a hydroxyapatite coating on the dental metal surface, and the Chinese patent CN1316274 adopts an electrolytic deposition method to prepare a hydroxyapatite coating, etc. However, the temperature of the plasma spraying process reaches more than 1,000 degrees, and it is impossible to introduce bioactive factors with limited stability into the coating. However, p...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/54A61L27/28A61L27/04
Inventor 翁文剑苗顺东程逵宋晨路杜丕一沈鸽赵高凌张溪文徐刚汪建勋韩高荣
Owner ZHEJIANG UNIV
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