Double-shell medicine sustained and controlled releasing carrier material and preparation method and application thereof

A technology of controlled release carrier and double shell layer, which is applied to the preparation of double shell drug sustained and controlled release carrier material, and the field of double shell drug sustained and controlled release carrier material, which can solve the problem of poor ability to control drug release and limit drug loading. and other problems, to achieve the effect of selective release, strong biocompatibility and low preparation cost

Inactive Publication Date: 2008-04-30
TECHNICAL INST OF PHYSICS & CHEMISTRY - CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

For example, liposomes and microemulsions can achieve higher drug loading, but their ability to control drug release is poor; polymer hydrogels can effectively control drug release, but their structure limits the drug loading.

Method used

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  • Double-shell medicine sustained and controlled releasing carrier material and preparation method and application thereof
  • Double-shell medicine sustained and controlled releasing carrier material and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] step 1)

[0034] Preparation cephradine aqueous solution, concentration is 15mg / ml. 0.2g of hollow silica microsphere dry powder (average particle diameter is 200nm, average shell thickness is 20nm, the shell layer has mesoporous property, and average pore diameter is 10nm) is ultrasonically dispersed in the cephradine aqueous solution, stirred at room temperature for several days, and centrifuged to obtain The drug-loaded microspheres were centrifuged and washed 3 times to remove the drug molecules adsorbed on the surface. Oven-dried to obtain drug-loaded hollow silicon dioxide microsphere dry powder.

[0035] Step 2)

[0036] Prepare polyelectrolyte solutions. Chitosan was dissolved in acetic acid solution with a mass concentration of 1% to form solution A, and the concentration of chitosan was 10 mg / ml. Polyacrylic acid was dissolved in deionized water to form solution B, and the concentration of acrylic acid was 10mg / ml.

[0037] Disperse the drug-loaded hollow...

Embodiment 2

[0042] With 0.05g average diameter is the hollow silica microsphere of 350nm (average shell thickness is 25nm, shell layer has mesoporous property, and average aperture is 13.5nm) replaces the hollow silica microsphere in embodiment 1 step 1), With 10mg / ml polyallylamine hydrochloride (poly(allylamine hydrochloride), PAH) aqueous solution replaces solution A in embodiment 1 step 2), with 10mg / ml poly 4-styrene sulfonate (poly( styrenesulfonate), the aqueous solution of PSS) replaces the solution B in the step 2) of embodiment 1, and stirs at room temperature for 30 minutes to replace the 10 minutes in the step 2 of the embodiment 1), and replaces the pH in the step 2) of the embodiment 1 with deionized water= Acetic acid / sodium acetate standard buffer solution of 3.6 and acetic acid / sodium acetate standard buffer solution of pH=3.8. Other steps 1-3 of Example 1 were repeated. Finally, four double-layer polyelectrolyte multilayer membrane-coated composite cephradine-loaded mic...

Embodiment 3

[0045] The hollow silica microspheres (average shell thickness is 15nm, and the shell has mesoporous properties, and the average pore diameter is 7nm) with an average particle diameter of 100nm replace the hollow silica microspheres in step 1) of Example 1, with 10mg The aqueous solution of polydiallyldimethylammonium chloride (poly(diallyldimethylammonium chloride), PDDA) replaces the solution A in step 2) of embodiment 1, and replaces the step 2 of embodiment 1 with 10mg / ml sodium alginate aqueous solution ), stirred at room temperature for 60 minutes instead of 10 minutes in step 2) of embodiment 1, and replaced the aqueous solution of cephradine in step 1) of embodiment 1 with 2.5 mg / ml cisplatin saline solution. Other steps 1-3 of Example 1 were repeated. Finally, four composite cisplatin-loaded microspheres coated with double-layer polyelectrolyte multilayer films were obtained.

[0046] The drug release performance evaluation method is the same as in Example 1. The res...

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Abstract

The invention relates to carrier materials of medicament sustained controlled release, a process for preparing the carrier materials and usage, in particular relating to carrier materials of double shell medicament sustained controlled release of a hollow silicon dioxde micro-balloon coated by pluralities layers f polyelectrolyte membranes, and the making method and usage of the carrier materials of double shell medicament sustained controlled release. The materials are prepared by the hollow silicon dioxde micro-balloon and the compatible polyelectrolyte. An inner shell of the carrier material of double shell medicament sustained controlled release is the hollow silicon dioxde micro-balloon, and an outer shell is composed of polarities layers of the polyelectrolyte membranes. A cavity of the hollow silicon dioxde micro-balloon can be a container for carrying medicament, and the polarities layers of the polyelectrolyte membranes of the outer shell can control the release rate of medicament molecules under different external environments. The carrier materials of double shell medicament sustained controlled release of the invention have high medicament-carrying capacity, and have certain targeting function, and environmental stimulus response of the medicament is release-controllable.

Description

technical field [0001] The present invention relates to a carrier material for sustained and controlled drug release and its preparation method and application, in particular to a double-shell drug sustained and controlled release carrier material with polyelectrolyte multilayer film-coated hollow silica hollow microspheres, and the double-shell layer The preparation method and application of drug sustained and controlled release carrier material. Background technique [0002] An important problem with traditional drug administration and drug delivery methods, such as tablets, injections, creams, and aerosols, is that the concentration of the drug in a short period of time is higher than the maximum dose required, and the drug concentration in the body is maintained for a short time , requiring multiple administrations, thereby increasing the cost of treatment and the toxic and side effects on normal tissues. Therefore, this traditional drug delivery method cannot meet the ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K47/42A61K47/36A61K47/32A61K47/04A61K45/00A61K39/395A61K31/545A61K31/337A61K33/24A61K9/16A61P31/04A61P35/00
Inventor 唐芳琼李琳琳陈东孟宪伟任俊张琳
Owner TECHNICAL INST OF PHYSICS & CHEMISTRY - CHINESE ACAD OF SCI
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