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Water soluble magnetic nanometer crystal with high dissolvability and method of producing the same

A magnetic nano, high solubility technology, applied in the direction of magnetic objects, magnetic materials, microsphere preparation, etc., can solve the problems that have not been reported in literature and domestic and foreign patents, and achieve the effect of simple technical route

Active Publication Date: 2011-02-09
苏州欣影生物医药技术有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

And we just use this special polymerization method, using thermal polymerization of high-boiling point monomers, to achieve in-situ modification of water-soluble polymers on the surface of magnetic nanocrystals at the same time as the formation of magnetic nanocrystals. Magnetic nanocrystals with water resistance, this preparation technology has not been reported in the literature and domestic and foreign patents

Method used

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  • Water soluble magnetic nanometer crystal with high dissolvability and method of producing the same
  • Water soluble magnetic nanometer crystal with high dissolvability and method of producing the same
  • Water soluble magnetic nanometer crystal with high dissolvability and method of producing the same

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0053] Dissolve 7.2345g of iron acetylacetonate in 500mL of N-vinylpyrrolidone to form a solution, put the above solution into a 1000mL three-neck flask, then pass in nitrogen gas to remove oxygen for 30-90 minutes, and heat at 190-210°C for 0.5-3 The reaction is carried out within hours, and at the same time as the formation of the magnetic nanocrystals, water-soluble and biocompatible poly-N-vinylpyrrolidone macromolecules are formed in situ on the surface of the nanocrystals. Then the reaction solution is cooled to room temperature, the reaction solution is precipitated with a mixed solvent of ethanol and ether, and magnetic particles with strong magnetic response are obtained by magnetic separation or centrifugation. Then, the ferroferrogen tetroxide magnetic nanocrystals with high crystallinity, narrow dispersion and strong magnetic response are obtained through multiple washings with a mixed solvent of ethanol and ether, magnetic separation and centrifugal separation. Th...

Embodiment 2

[0055] Weigh 4.9258g five-carbon base iron (Fe(CO) 5 ) was dissolved in 500mL N-vinylpyrrolidone to form a solution, the above solution was put into a 1000mL three-neck flask, and then nitrogen gas was introduced to remove oxygen for 30-90 minutes, and heated at 190-210°C for 0.5-2 hours. Simultaneously with the formation of crystals, water-soluble and biocompatible poly-N-vinylpyrrolidone macromolecules are formed in situ on the surface of the nanocrystals. Then the reaction solution was cooled to room temperature, and the reaction solution was precipitated with methanol solvent, and subjected to centrifugation or magnetic separation to obtain a black precipitate. Re-dissolving the precipitate with methanol solvent, centrifuging the precipitate, and drying to obtain ferroferric oxide magnetic nanocrystals with high crystallinity, narrow dispersion, and strong magnetic response. The magnetic nano crystal can be well dissolved in neutral water (pH=6-8), so as to obtain a neutr...

Embodiment 3

[0057] Weigh 4.8862g of anhydrous ferric chloride and dissolve it in 500mL of N-vinylpyrrolidone to form a solution, put the above solution into a 1000mL three-necked flask, then pass through nitrogen to remove oxygen for 30-90 minutes, and heat at 190-210°C In 1-4 hours, water-soluble and biocompatible poly(N-vinylpyrrolidone) macromolecules are formed on the surface of the nanocrystals at the same time as the magnetic nanocrystals are formed. Then the reaction solution was cooled to room temperature, and the treatment method was as in Example 1. The black precipitate obtained after drying is dissolved in neutral water (pH=6-8) to obtain a neutral magnetic fluid with strong magnetic response and superparamagnetism. The particle shape is a spherical magnetic nano crystal, and the particle diameter is between 10 and 14 nanometers.

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Abstract

The invention belongs to the technical fields of material chemistry, nano science and catalytic chemistry as well as medical field and in particular relates to applying a 'one pot' synthesis to prepare magnetic nano crystalline with a high solubility and a high crystallinity in neutral water and a preparation method thereof. The technique of the invention is characterized by applying solvent with a high boiling point, catalytic function, reducing function and polymerization function to carry out thermal decomposition for organometallic precursors or metal inorganic salt compound, so as to form magnetic nano crystalline, realize the modification in situ of water-soluble polymer on the surface of the nano crystalline and obtain water-soluble nano crystalline with a high solubility at the same time. The crystalline is mainly characterized in that: the crystalline can be dissolved in neutral water (PH=6-8); the formed solution keeps stability for a long time; the main inorganic elements include iron, cobalt, nickel, manganeses and oxide thereof; the crystalline is in a ball shape or in a petal shape; the shape and size control is realized by controlling the concentration and heating-up time for the precursors of the magnetic nano crystalline-the organic precursors or the inorganic salt.

Description

technical field [0001] The technical field of the invention is material chemistry, nanoscience, catalytic chemistry and medicine, and particularly relates to the preparation of high-crystallinity magnetic nanocrystals with high solubility in neutral water by a "one-pot" method and a preparation method thereof. Background technique [0002] Magnetic nanocrystals are widely used in magnetic fluids, catalysts, biology (medicine), data storage and other fields. Among them, the application in the biological field, including: magnetic resonance imaging enhancement (MRI), cell separation and labeling, DNA separation, tumor detection and treatment, targeted drug carriers, etc., has attracted great attention from scientists and high-tech companies from all over the world. [0003] At present, the production methods of magnetic nanoparticles mainly include ball milling method, biosynthesis method, sonication method, micellar (reverse micelles) method, co-precipitation method and therm...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): H01F1/00C04B35/628B01J13/14A61K49/06A61K47/00
Inventor 高明远鹿现永
Owner 苏州欣影生物医药技术有限公司
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