Human cytokine and use thereof

A technology of cytokines and host cells, applied in the field of small interfering RNA and polypeptide preparation, can solve problems such as unsatisfactory curative effect, large toxic and side effects, and impact on clinical application
CN101190944AInactive Publication Date: 2008-06-04SINOGENOMAX +1
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
SINOGENOMAX
Publication Date
2008-06-04
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention discloses a new secretive cytokine NS128 of human beings, which relates to a coding amino acid sequence of the cytokine or the polynucleotide of the cytokine fragment, containing a genetic engineering carrier and a host cell of the polynucleotide. The invention also relates to a production method of the amino acid sequence of the cytokine or the polypeptide of the cytokine fragment and the production method of the polypeptide as well as a small interference RNA, which suppresses the expression of the cytokine. The invention also relates to a salt which contains the polynucleotide or the salt of acceptable drugs, or a medical composition of the polypeptide or the salt of acceptable drugs. The invention further relates to applications of the polynucleotide of the cytokine, the polypeptide or the small interference RNA in preparation of prevention and / or treatment medicines for tumor, infection, hematopoietic disorder and autoimmune disease, etc., in particular having clinical implications for tumor, inflammation and nervous system disease and so on related to MAPK signal pathway. The invention also relates to a method of in vitro testing whether the expression of the polynucleotide or the polypeptide changes. The invention also relates to a monoclonal or polyclonal antibody which is specifically bound with the polypeptide or an active fragment of the polypeptide.
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Description

technical field

[0001] The invention relates to the fields of molecular biology, genetic engineering, oncology and cell biology. Specifically, the present invention relates to a novel cytokine polynucleotide and polypeptide, a vector or host cell containing the polynucleotide, and a preparation method and use of the polypeptide. The invention also relates to a small interfering RNA that inhibits the expression of the cytokine. The present invention also relates to the application of the cytokine or small interfering RNA in the preparation of drugs for the prevention and / or treatment of tumors, infections, hematopoietic dysfunction, autoimmune diseases, etc., especially the tumors, inflammations and nervous system diseases related to the MAPK signaling pathway Wait. Background technique

[0002] Cytokines are small molecule polypeptide factors synthesized and secreted by immune cells and non-immune cells of the body, and they regulate various cellular physiological function...

Claims

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