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Oral instant quick-effective emulsion membrane and three-dimensional printing preparation method

An oral instant-dissolving and drug-film technology, which is applied in the directions of pharmaceutical formulations, medical preparations containing active ingredients, and sheet-like transportation, to achieve a high degree of automation and a flexible preparation process.

Inactive Publication Date: 2008-09-24
DONGHUA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

How to make full use of the technical advantages of 3DP, make use of the high porosity characteristics of 3DP products, and the technological performance of loading drugs in solid excipients in liquid form during the preparation process to prepare instant film preparations, there are no relevant reports at home and abroad

Method used

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  • Oral instant quick-effective emulsion membrane and three-dimensional printing preparation method
  • Oral instant quick-effective emulsion membrane and three-dimensional printing preparation method
  • Oral instant quick-effective emulsion membrane and three-dimensional printing preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Example 1: 3D printing powder formulation

[0029]Sieve lactose, polyvinylpyrrolidone, microcrystalline cellulose, and mannitol powder one by one, except for microcrystalline cellulose (12-20 μm), select powders with a particle size distribution between 75-100 μm and mix them evenly in proportion , to make a layered mixed powder, and the composition content is as follows by weight percentage:

[0030] Lactose 20 parts

[0031] Polyvinylpyrrolidone K30 20 parts

[0032] Mannitol 20 parts

[0033] Microcrystalline cellulose 40 parts

Embodiment 2

[0034] Example 2: Preparation of printing solution and selection of some process parameters

[0035] Since the polyvinylpyrrolidone K30 in the powder is easily soluble in ethanol. Mannitol and lactose are soluble in water, so the mixture of the two is selected as the solvent of the printing solution. Put a 12cm watch glass on the 1 / 10,000th electronic balance, put 2.0g of mixed powder into it, perform layering, and adjust to zero. At room temperature, use a quantitative spray bottle to spray the tested printing solution twice continuously, record the initial mass of the sprayed printing solution, and record the weight every 30s, repeat 6 times, take the average value, and compare the quality change with time drawing.

[0036] Such as image 3 As shown, water evaporates from the mixed powder at a relatively constant rate of 0.2289 mg s -1 , while ethanol and water-ethanol mixture have a linear fast volatilization stage at the beginning, and then the volatilization rate beco...

Embodiment 3

[0041] Embodiment 3: prepare quick-dissolving quick-acting drug film

[0042] The operation and preparation are directly controlled by the computer terminal output instructions. Spread a layer of mixed powder with a thickness of 100 μm, spray 2 times of 90% ethanol aqueous solution containing 5% sodium lauryl sulfate as a penetration enhancer, and form the bottom surface of the drug film, and then the piston rod drives the powder bed of the workbench to descend as a whole, Prepare a new layer of powder.

[0043] The mixed powder of the subsequent 3 to 5 layers of laying remains unchanged, and the thickness of the laying layer is 100 μm. The powder is bonded and formed in a selective area with 90% ethanol aqueous solution containing 5% of the drug ibuprofen, and each layer is sprayed twice to form a carrier. Drug area, the diameter of the drug film is 18mm. Finally, the obtained drug film is dried and powder-removed to obtain the product.

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Abstract

The invention relates to an instant and fast-effect oral medicinal film and the three-dimensional printing preparation method thereof, and consists of a drug-containing area and a penetration-promoting area respectively formed by bonding adhesive liquid containing drugs and penetration-promoting agents with layering adjuvant powders. The preparation is as follows: 3DP technology is adopted and the preparation property of layer-by-layer printing and layer-upon-layer supraposition according to the CAD model is utilized to load drugs in the carrier adjuvant extremely evenly and dispersedly while the print spraying bonds with the powder by dissolving the drugs in a print solution. As the adjuvants are reasonably selected and the prepared medicinal film has extremely high porosity, the medicinal film can dissolve rapidly to obtain fast treatment effect. The preparation method has very flexible and simple process and high degree of automation.

Description

technical field [0001] The invention belongs to the field of medical drugs, and in particular relates to a medicine film which can be rapidly dissolved in the oral cavity to obtain a rapid therapeutic effect and a three-dimensional printing preparation method thereof. Background technique [0002] In recent years, the research hotspot of sustained and controlled release preparations is shifting from the traditional first-order or zero-order drug release system to a more targeted positioning and timed release system for disease onset, in order to achieve high efficiency, low toxicity, less side effects and convenience The purpose of this medicine is to develop towards the direction of group-specific and individualized drug delivery. An example is the oral instant / rapid disintegration drug delivery system, which can quickly disintegrate, disperse or dissolve in saliva in the oral cavity, and the patient can take the drug smoothly without water or with a very small amount of wa...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/70A61K45/06
Inventor 朱利民余灯广申夏夏张晓飞
Owner DONGHUA UNIV
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