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Chinese medicine compound percutaneous absorption patch for treating menorrhalgia and preparation method thereof

A transdermal, compound technology, applied in the field of traditional Chinese medicine for the treatment of dysmenorrhea, to achieve the effect of high content, long drug effect, and increase skin penetration rate

Inactive Publication Date: 2008-09-24
TIANJIN ZHONGBAO PHARMACY
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

It has no direct inhibitory effect on the cerebral cortex, but it can block the ascending activation system and descending inhibitory function of the brainstem reticular structure

Method used

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  • Chinese medicine compound percutaneous absorption patch for treating menorrhalgia and preparation method thereof

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preparation example Construction

[0039] A preparation method of a traditional Chinese medicine compound transdermal absorption patch for treating dysmenorrhea, comprising the following steps:

[0040] (1) CO2 is used for the powder or coarse powder of the Chinese herbal medicine turmeric 2 Supercritical extraction device, under the condition of pressure 30MPa, temperature 50-55 ℃, extraction for 3-4 hours, respectively to obtain and turmeric extract;

[0041] (2) Using the traditional ethanol extraction method on the powder or coarse powder of Chinese medicinal materials Corydalis Corydalis, Evodia Evodia, and Dried Ginger, respectively, to obtain Corydalis Corydalis Extract, Evodia Evodia Extract, and Dried Ginger Extract;

[0042] (3) Weigh Evodia rutaecarpa extract, turmeric extract, dried ginger extract, and β-cyclodextrin inclusion compound in proportion, and disperse them strongly through a nano-microemulsion disperser to control the microemulsion particles at the nanometer level to prepare a microemuls...

Embodiment 1

[0050] formula:

[0051] Evodia Evodia Extract 6g

[0052] Turmeric CO 2 Supercritical Extraction Oil 3g

[0053] Corydalis extract 16.5g

[0054] Dried Ginger Extract 6g

[0055] Transdermal absorption enhancer Laurazone Azone 3g

[0056] β-cyclodextrin inclusion complex 10g

[0057] Medical pressure sensitive adhesive 300g

[0058] Makes 350 stickers

Embodiment 2

[0060] formula:

[0061] Evodia Evodia Extract 1.5g

[0062] Turmeric CO 2 Supercritical Extraction Oil 3g

[0063] Corydalis extract 12g

[0064] Dried Ginger Extract 1.5g

[0065] Transdermal absorption enhancer Laurazone Azone 1.5g

[0066] β-cyclodextrin inclusion complex 9g

[0067] Medical pressure sensitive adhesive 300g

[0068] Makes 350 stickers

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Abstract

The invention discloses a Chinese traditional medicine compound trans-dermal absorption plaster for treating dysmenorrhea and the preparation method thereof. The plaster is prepared with the following materials by weight ratios: 0.5-3 portions of evodia rutaecarpa extract, 0.5-3 portions of rhizoma zingiberis, 4-6 portions of fumitory extract, which is extracted from Chinese traditional medicine of fumitory by traditional extraction method, 1-3 portions of turmeric extract, which is extracted from Chinese traditional medicinal materials by carbon dioxide supercritical extraction, 0.5-2 portions of trans-dermal accelerant, and 100-150 portions of pressure-sensitive adhesive. The materials are dispersed by nano-microemulsion dispersing machine intensively, and the particle diameter of the microemulsion is limited in nano-grade. The trans-dermal absorption preparation of the invention enters into the Subcutaneous capillary through skin cell gaps, and gets to the focus along with the blood circulation; the biological availability is improved by more than 10 times higher than the equivalent products, the curative effect is improved notably, the usage is convenient, and the adaptability of the sufferer is improved.

Description

technical field [0001] The invention relates to a traditional Chinese medicine for treating dysmenorrhea, in particular to a traditional Chinese medicine compound transdermal absorption patch for treating dysmenorrhea and a preparation method thereof. Background technique [0002] Transdermal drug delivery system or percutaneous absorption patch refers to a type of preparation that is applied through the skin, and the drug is absorbed through the skin into the blood circulation of the whole body and reaches an effective blood concentration to achieve disease treatment or prevention. The characteristic of the transdermal absorption patch is that the transdermal drug delivery system can avoid the first-pass effect of the liver and the inactivation of the drug in the gastrointestinal tract. Effective blood concentration or physiological effects, avoiding the peak and valley phenomenon of blood concentration caused by oral administration. Reduce toxic and side effects, reduce a...

Claims

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Application Information

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IPC IPC(8): A61K36/9068A61K9/70A61P15/00A61P29/02
Inventor 高惠明杨吉田
Owner TIANJIN ZHONGBAO PHARMACY
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