Self-assembly short peptides constructed by D type amino acid, use for nano-biomedicine

A technology of self-assembling short peptides and amino acids, which is applied in the field of nanobiomedicine, can solve the problems of limited application range and short nanofibers, and achieve the effects of improving the success rate, obvious social benefits and economic benefits
CN101337985AInactive Publication Date: 2009-01-07成都瑞恩生物技术有限公司
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
成都瑞恩生物技术有限公司
Publication Date
2009-01-07
Estimated Expiration
Not applicable · inactive patent

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Abstract

A self-assembling peptide constituted by D-amino acid is named as d-RAD16 and has an amino acid sequence represented by SEQ ID NO.1 in a sequence list. Test shows that hydrogel formed by the self-assembling peptide can be used for preparing a moisture keeping and water locking agent, and has the function of stopping bleeding rapidly for wound, so that the hydrogel can be used for preparing a hemostatic drug suiting clinical application by adding a pharmaceutically acceptable carrier or excipient. Nanofiber scaffold formed by the self-assembling peptide supports the growth of various cells and can be used as the substrate material for 3D cell culture. The substrate material for 3D cell culture can simulate the in-vivo environment to support the 3D growth of cells in the substrate, thereby providing a cell 3D culture drug screening mode capable of simulating the in-vivo environment and improving the success rate for the development of new drugs.
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Description

technical field

[0001] The invention belongs to the field of self-assembled short peptides, in particular to a self-assembled short peptide composed of D-type amino acids and its application in nanometer biomedicine. Background technique

[0002] Since the advent of short self-assembled peptides in the 1990s, they have developed rapidly. A variety of self-assembled short peptides with different structures have been synthesized and have been successfully applied in the fields of biotechnology and nanobiotechnology, especially cell engineering and tissue engineering. , drug controlled release, regenerative medicine, membrane protein fields and energy engineering (see Zhang, S., Nature Biotechnology, 2003), but most of the self-assembled short peptides synthesized are self-assembled short peptide systems constructed from L-type amino acids (Zhang, S., US Patent, No.5,670,483,1997; No.5,955,343.1999; No.20,020,160,471,2002; No.2004020549; 2006), and the self-assembled short pept...

Claims

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