Amino acid injection and preparation method thereof

Abstract

The invention discloses an amino acid injection, commonly known as propranolol, which relates to a pharmaceutical preparation containing 18 kinds of amino acids. The amino acid injection contains the following components per 1,000 milliliters: isoleucine, leucine, methionine, phenylalanine, threonine, tryptophan, valine, glycine, alanine, glutamic acid, aspartic acid, proline, serine, cystine, lysine hydrochloride or lysine acetate, arginine hydrochloride or arginine, histidine hydrochloride or histidine, tyrosine or acetyl tyrosine, and sodium bisulfite or sodium meta-bisulphite. The osmoticpressure ratio of the amino acid injection is lower than 1.8, which effectively reduces the pain for a patient in infusion; the added quantity of antioxidant is small, which can reduce the clinical adverse reactions; and an infusion bottle body is large, which is convenient to mix liquid in clinical application.

Description

【Technical field】 The invention belongs to an amino acid injection composed of 18 kinds of amino acids and an antioxidant—commonly known as proamine and a manufacturing method thereof. 【Background technique】 Proteins are the building blocks of cellular structures, act as biochemical catalysts, and are important regulators of gene expression. The basic unit of protein structure is the amino acid. The human body needs to take in a certain amount of protein every day to meet the needs of life activities. When it is unable to take in enough amount from the gastrointestinal tract for some reason, it must be supplemented by intravenous amino acid solution. Protein nutrition is of great significance to the prevention and treatment of diseases, especially after surgical trauma or postoperative, the protein decomposition or metabolism in the patient's body increases sharply, and nitrogen negative balance soon appears, which further deteriorates the condition. According to reports,...

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Problems solved by technology

For example, the compound amino acid injection (18AA), which is common in the market, has antioxidants greater than 0.5g / L, which greatly increases the adverse reactions in clinical use.

(2) Infusion pain: The currently commonly used compound amino acid injection (18AA) is not more effective in prescriptions without sodium hydroxide as a pH value regulator in the second volume six volumes of the "Ministry of Health Drug Standards" The quality of the control product, and the osmotic pressure is too high, causing pain during clinical infusion

(3) Inconvenient clinical use: In order to improve the utilization of amino acids in the body, amino acid infusions often add sorbitol or xylitol as calories in the prescription. The calories of alcohol are far lower than that of glucose and fructose. It is not enough to produce sorbitol and xylitol for severe trauma patients. At the same time, glucose and fructose cannot be sterilized with amino acids at the same time, so they need to be added in clinical use

And because, the amino acid infusion specification and the container on the market all adopt the same specification (as 250ml, adopt 250ml standard specification infusion bottle), so can't add other calorie increasers or other nutritional infusion in the inside of the medicinal liquid again

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