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Method for preparing myristicin from sinkiang Ligusticum sinense

A technology of myristate and ligustum, which is applied in the field of extraction and preparation of natural product component-myristate, can solve problems such as no literature and patent reports on anti-phytopathogenic fungi activity, and achieves low cost, high yield, raw material and the like. easy-to-get effect

Inactive Publication Date: 2012-07-04
TARIM UNIV
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Problems solved by technology

The main component of Xinjiang Ligusticum is volatile oil, and the content of myristicin in Xinjiang Ligusticum volatile oil is relatively high, which is an ideal plant resource of myristicin, but the method of preparing myristicin and its anti-phytopathogenic fungal activity have not been reported in literature and patents

Method used

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  • Method for preparing myristicin from sinkiang Ligusticum sinense
  • Method for preparing myristicin from sinkiang Ligusticum sinense
  • Method for preparing myristicin from sinkiang Ligusticum sinense

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Embodiment 1

[0047] 1) steam distillation

[0048] Get Xinjiang Ligusticum edulis pulverizes, after No. 3 sieves, obtain Xinjiang Ligusticum edulis coarse powder 1.5 kilograms, according to the ratio of material-liquid ratio 1:5 (weight ratio) after Xinjiang Ligusticum edulis and water are mixed and cold-soaked for 6 hours, Then place it in a steam distillation device and distill for 6 hours until no volatile oil condenses and sinks. After the volatile oil is separated with a separatory funnel, the lower layer essential oil is combined to obtain 18.3 grams, and the yield is 1.2%. See results Figure 5 and table1;

[0049] Among them, GC-MS analysis conditions: AI / AS 3000 Trace GC 2000 DSQ gas chromatography mass spectrometer; DB-1701 capillary column (30m×0.25mm, film thickness 0.25μm); heating program: initial temperature 40°C, hold for 1 minute , 10°C / min to 200°C, hold for 10 minutes; inlet temperature 200°C, 40°C; injection volume 1μl, split ratio 100:1; ion source temperature 250°C,...

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Abstract

The invention relates to a method for preparing myristicin from Xinjiang ligusticum. The method uses the root of Xinjiang lingusticum, and the lower layer of essential oil is extracted by water vapor distillation after drying, grinding and screening; then silica gel column chromatography is carried out, and after gradient elution is carried out on petroleum ether and methylene dichloride, the stream part which is purple under an ultraviolet lamp on a GF254 silica gel plate is collected and gathered, thus obtaining the crude product, the myristicin content of which is above 90 percent; and then the crude myristicin is mixed with an organic alcohol solvent, and after refrigeration and crystallization at ultra-low temperature, white crystal can be obtained, the myristicin content of which isabove 99 percent, and at room temperature, the product is achromatic oil liquid. The compound has strong isolated fungicidal activity to plant pathogenic fungi, wheat scab fungi and the like. The method for refining the myristicin has the advantages of easily obtained materials, simple operation, high yield and high purity of myristicin, and the myristicin can be used as pure myristicin required by medicine and pesticide research and development.

Description

technical field [0001] The invention relates to a method for extracting and preparing natural product component-myristyl ether and its application, belonging to the technical field of medicine and pesticides. Background technique [0002] Myristyl ether, namely 5-allyl-1-methoxy-2,3-(methylenedioxy)benzene, molecular formula C 11 h 12 o 3 , molecular weight 192.21, CAS number: 607-91-0, with such as figure 1 The chemical structure shown, figure 2 The infrared spectra shown and image 3 The mass spectrum shown. It is the main aromatic component of the volatile oil of Myristicafragans Houtt, a plant of the genus Myristicaceae Myristicaceae, and the content of myristicin in the volatile oil of Myristica is 4-8% (Hallstroem and Thuvander, 1997). In addition, myristicin is also distributed in Apium, Anethum, Crithmum, Foeniculum, Petroselinum, anise Pimpinella, Ridolfia, Levisticum, Pastinaca, Ligusticum and Daucus, etc. (Harborne et al., 1969). [0003] The physiologica...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07D317/64A01N43/30A01P3/00
Inventor 万传星刘文杰董红强张利莉
Owner TARIM UNIV
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