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Degradable nano calcium phosphorous compound reinforced magnesium-zinc alloy bone fracture internal fixation material

A technology of phosphorus compounds and fixing materials, applied in medical science, prosthesis, etc., to achieve the effect of improving strength and corrosion resistance

Inactive Publication Date: 2009-04-22
TIANJIN UNIVERSITY OF TECHNOLOGY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Relevant research has not been reported at home and abroad

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] Put 4 grams of Zn and 194 grams of Mg into the graphite crucible of the melting furnace, and evacuate to 1×10 -2 Pa, pass into BF 6 with CO 2 Mixed gas as protection, heated at 750°C for 15 minutes to prepare Mg-Zn alloy melt;

[0020] Pour 2 grams of n-HA and Mg-Zn alloy melt directly into the double-helix rheological pulper, and pass it into the BF 6 with CO 2 Mixed gas as protection, at 750 ° C, after vigorous stirring for 30 minutes, deposited into the crystallizer to obtain a round rod with a diameter of 60 mm;

[0021] Extrusion and heat treatment of materials: Heat a φ60mm round rod to 425°C, keep it warm for 5 hours, and then heat-extrude it to φ8mm. Then solution treatment at 400°C for 1h, and aging heat treatment at 170°C for 10h.

[0022] The obtained biodegradable nano-calcium-phosphorus compound-reinforced magnesium-zinc alloy fracture internal fixation material has the following component weight percentages: 1% of n-HA, 2% of Zn, and 97% of Mg.

Embodiment 2

[0024] Put 4 grams of Zn and 186 grams of Mg into the graphite crucible of the melting furnace, and evacuate to 1×10 -2 Pa, pass into BF 6 with CO 2 Mixed gas as protection, heated at 750°C for 15 minutes to prepare Mg-Zn alloy melt;

[0025] Pour 10 grams of nano-HA and Mg-Zn alloy melt directly into the double-helix rheological pulper, and pass it into the BF 6 with CO 2 Mixed gas as protection, at 750 ° C, after vigorous stirring for 30 minutes, deposited into the crystallizer to obtain a round rod with a diameter of 60 mm;

[0026] Extrusion and heat treatment of materials: Heat a φ60mm round rod to 425°C, keep it warm for 5 hours, and then heat-extrude it to φ8mm. Then solution treatment at 400°C for 1h, and aging heat treatment at 170°C for 10h.

[0027] The obtained biodegradable nano-calcium-phosphorus compound-reinforced magnesium-zinc alloy fracture internal fixation material has the following component weight percentages: 5% of n-HA, 2% of Zn, and 93% of Mg.

Embodiment 3

[0029] Put 4 grams of Zn and 176 grams of Mg into the graphite crucible of the melting furnace, and evacuate to 1×10 -2 Pa, pass into BF 6 with CO 2 Mixed gas as protection, heated at 750°C for 15 minutes to prepare Mg-Zn alloy melt;

[0030] 20 grams of n-HA and Mg-Zn alloy melt (a total of 200g) was directly poured into the double-helix rheological pulper, and passed into the BF 6 with CO 2 Mixed gas as protection, at 750 ° C, after vigorous stirring for 30 minutes, deposited into the crystallizer to obtain a round rod with a diameter of 60 mm;

[0031] Extrusion and heat treatment of materials: Heat a φ60mm round rod to 425°C, keep it warm for 5 hours, and then heat-extrude it to φ8mm. Then solution treatment at 400°C for 1h, and aging heat treatment at 170°C for 10h.

[0032] The obtained biodegradable nano-calcium-phosphorus compound-reinforced magnesium-zinc alloy fracture internal fixation material has the following component weight percentages: n-HA 10%, Zn 2%, an...

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Abstract

The invention discloses a degradable nano calcium-phosphor compound reinforced magnesium-zinc alloy fracture inner fixing material. The inner fixing material comprises the following components in weight percentage: 1 to 10 percent of nano calcium-phosphor compound, 1 to 6 percent of Zn, and the balance being Mg. Nano hydroxyapatite rod-like granule or beta-calcium phosphate is used as a reinforcement to prepare a nano calcium-phosphor compound reinforced Mg-Zn composite material. Magnesium matrix is reinforced by an alloy element Zn, and refined grains of trace nano calcium-phosphor compound are added, so as to further reinforce alloy, improve alloy plasticity, and improve erosion resistance; and at the same time, the nano grains can effectively adsorb the matrix eroding product, namely hydrogen, and is induced to form a protection layer. The degrading rate of the composite material is controlled by the adding amount of the nano calcium-phosphor compound; the degraded products Mg<2+>, Zn<2+>, Ca<2+> and the like are necessary trace elements for human body. The material does not contain toxic elements, has favorable mechanical property, degrading rate and biocompatibility, can become a degradable fracture inner fixing material of new generation, avoids secondary operations, and meets clinical use requirements.

Description

technical field [0001] The invention relates to a biological bone repair material, in particular to a biodegradable nano-calcium phosphorus compound reinforced magnesium-zinc alloy fracture internal fixation material. Background technique [0002] At present, stainless steel and titanium alloys are widely used clinically for internal fixation of fractures, but their stress shielding effect and harmful ion dissolution often lead to implant failure. In particular, the implanted alloy does not degrade, and the injured bone must be taken out by a second operation after healing, which greatly increases the economic and psychological burden and physical pain of the patient. Therefore, in bone injury surgery, more and more attention has been paid to replacing traditional metal materials with absorbable materials. Degradable polymers represented by polylactic acid and its composites have been clinically applied recently. However, the mechanical properties of this type of material ...

Claims

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Application Information

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IPC IPC(8): A61L27/12A61L27/04
Inventor 陈民芳叶新羽刘德宝由臣
Owner TIANJIN UNIVERSITY OF TECHNOLOGY
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