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Release oxygen type porous inorganic/organic composite stent material

A technology of composite scaffolds and scaffold materials, which is applied in the fields of medical science, microcapsule preparation, microsphere preparation, etc., can solve the problems of poor connectivity between pores and difficult to control pore size, and achieves promotion of adhesion, improvement of mechanical properties, and enhancement of biological activity. Effect

Inactive Publication Date: 2013-04-24
WUHAN UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, this method is not suitable for the preparation of large-volume scaffolds, and the connectivity between pores is poor; the porous scaffold material obtained by thermally induced phase separation has good pore connectivity, but the pore size is not easy to control

Method used

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  • Release oxygen type porous inorganic/organic composite stent material
  • Release oxygen type porous inorganic/organic composite stent material
  • Release oxygen type porous inorganic/organic composite stent material

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] Paraffin spherical particles were prepared by suspension method. Weigh 10g of block paraffin wax with a melting point of 55°C and 100mL of polyvinyl alcohol aqueous solution with a concentration of 5mg / mL. After the temperature of the alcohol solution is stable, pour the polyvinyl alcohol solution into a beaker filled with liquid paraffin, and stir at a high speed to disperse the paraffin into numerous small paraffin droplets. Then quickly pour 200mL of ice water. Accelerate the solidification of small paraffin droplets to form paraffin microspheres. Rinse the paraffin particles with distilled water 4 to 5 times to remove impurities. Classify the obtained paraffin particles through a national standard sieve to obtain spherical particles of 100-500 μm, and then dry them in a vacuum drying oven.

[0039] Weigh 2g of Pluronic F127 and add it into 100ml of 1,4-dioxane, stir at 25°C to dissolve it completely. This solution contains 0.3g CaO 2 and 0.85g CaHPO 4 Particle...

Embodiment 2

[0041] Paraffin spherical particles were prepared by suspension method. Weigh 10g of block paraffin wax with a melting point of 55°C, measure 150mL of polyvinyl alcohol aqueous solution with a concentration of 5mg / mL, put the above two items in an oven set at 80°C, and keep for 1h until the paraffin wax is completely melted, and the polyethylene After the temperature of the alcohol solution is stable, pour the polyvinyl alcohol solution into a beaker filled with liquid paraffin, and stir at a high speed to disperse the paraffin into numerous small paraffin droplets. Then quickly pour 200mL of ice water. Accelerate the solidification of small paraffin droplets to form paraffin microspheres. Rinse the paraffin particles with distilled water 4 to 5 times to remove impurities. Classify the obtained paraffin particles through a national standard sieve to obtain spherical particles of 100-500 μm, and then dry them in a vacuum drying oven.

[0042] Weigh 3g of Pluronic F127 into 1...

Embodiment 3

[0044] Paraffin spherical particles were prepared by suspension method. Weigh 10g of block paraffin wax with a melting point of 55°C, measure 200mL of polyvinyl alcohol aqueous solution with a concentration of 5mg / mL, put the above two items into an oven with a temperature set at 80°C, and keep for 1.5h until the paraffin wax is completely melted. After the temperature of the vinyl alcohol solution is stable, pour the polyvinyl alcohol solution into a beaker filled with liquid paraffin, and stir at a high speed to disperse the paraffin into countless small paraffin droplets. Then quickly pour 250mL of ice water. Accelerate the solidification of small paraffin droplets to form paraffin microspheres. Rinse the paraffin particles with distilled water 4 to 5 times to remove impurities. Classify the obtained paraffin particles through a national standard sieve to obtain spherical particles of 100-500 μm, and then dry them in a vacuum drying oven.

[0045] Weigh 4g of Pluronic F1...

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Abstract

The present invention provides a release oxygen type stephanoporate abio / organic composite stent material which is composed of abio-hyperoxide, anhydrous hydrogen phosphate and degradable polymericcompound which contains non-ionic surface active agent, wherein, hyperoxide weight is 1%-10% of degradable polymericcompound weight, molar ratio of anhydrous hydrogen phosphate to hyperoxide is 1.0-2.0:1, non-ionic surface active agent weight is 10%-40% of degradable polymericcompound weight, the porosity of the stent material is larger than 90%. A preparing method includes steps as follows: preparing a ceresin wax micro-ball firstly, preparing a symmetric suspension body composed of non-ionic surface active agent, hyperoxide, anhydrous hydrogen phosphate and degradable polymericcompound, pouringin a die equipment filled with ceresin wax micro-ball, then freezing forming, freezing dehydration and removing organic solvent, finally, removing ceresin wax micro-ball by using organic solvent andobtaining the products. The stent material has advantages of continuous oxygen releasing, favorable biocompatibility, biodegradability, biological activity and hydrophilicity which is suitable for thebiological medicine field and the organizing engineering project field.

Description

technical field [0001] The invention relates to a porous support material composed of oxygen-releasing and degradable polymers and inorganic particles and a preparation method thereof. Background technique [0002] Oxygen is an important factor for cell survival and regulation of cell metabolism. Avascular cartilage is an oxygen-deficient tissue and, therefore, all cells in the human body (including animals) are dependent on oxygen, except chondrocytes, which can survive in a hypoxic environment. After oxygen enters the alveoli, it enters the blood through the diffusion of the respiratory membrane, and is carried by the hemoglobin in the red blood cells in the blood, and is transported by the blood to the tissues of the whole body through the vascular network to meet the needs of cell metabolism. Proper vascularization is therefore essential for the tissue. [0003] Tissue engineering is to plant autologous primary cells or stem cells with relevant functions on a biocompat...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/44A61L27/56B01J13/02A61L27/02A61L27/12A61L27/18A61L27/16A61L27/20A61L27/24
Inventor 戴红莲毛恩亮李世普韩颖超张平雷军
Owner WUHAN UNIV OF TECH
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