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Preparation method of double-network hydrogel

A technology of hydrogel and double network, applied in the field of preparation of hydrogel, can solve the problems of poor tensile properties of double network hydrogel, cumbersome polyethylene glycol steps, low water content of hydrogel, etc. The effect of mechanical properties, high water absorption, and simple preparation process

Inactive Publication Date: 2009-12-23
ZHEJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0008] For method (1), a longer synthesis time is required, including two steps of ultraviolet radiation, which takes 20 hours, and swelling equilibrium takes 24 hours, a total of 44 hours, and the tensile properties of the final double network hydrogel are relatively poor.
For method (2), the preparation of polyethylene glycol with double bonds at both ends in the early stage is cumbersome, requires two-step recrystallization, and also requires a long preparation time, and the conversion rate of the final reaction is low, so it is necessary to remove unreacted components
For method (3), it is necessary to prepare macromolecular microspheres by emulsion polymerization, the reaction time is long, the subsequent processing is cumbersome, and γ-ray radiation is required, which is dangerous and the equipment cost is high
For method (4), the water content of the hydrogel is low, and low-temperature freezing equipment is required, and a large amount of polyvinyl alcohol and polyethylene glycol are used, and the cost is higher
At present, there is no report on the preparation of high water absorption and high strength double network hydrogel by this method.

Method used

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  • Preparation method of double-network hydrogel
  • Preparation method of double-network hydrogel
  • Preparation method of double-network hydrogel

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042] Weigh 1.04g of 2-acrylamide-2-methylpropanesulfonic acid, cross-linking agent N, N'-methylenebisacrylamide 0.03g, initiator α-ketoglutarate 0.009g, polyethylene glycol ( Molecular weight 20000) 1.0g, then add 5mL deionized water, dissolve evenly, pour this solution into a silicone sheet mold, 2000 watts of strong ultraviolet radiation for 30s, to obtain a single network gel. Weigh 21.4g of acrylamide, 0.04g of cross-linking agent N,N'-methylenebisacrylamide, 0.1g of initiator α-ketoglutaric acid, add 150mL of deionized water, and mix evenly. In this solution, until the swelling is balanced, take it out, and irradiate it with weak ultraviolet light at 15 watts for 12 hours to obtain a high-strength double-network hydrogel. The hydrogel can absorb water 12 times its own weight, has a tensile strength of 0.45MPa, a breaking elongation of 260%, a compressive strength of 15MPa, and a compressive deformation rate of over 99%.

Embodiment 2

[0046] Weigh 0.01g of 2-methacrylamide-2-methylpropanesulfonic acid, cross-linking agent N, N'-methylenebismethacrylamide 0.075g, initiator 2,4,6 (trimethylbenzene Formyl)diphenylphosphine oxide 0.025g, ammonium sulfate 0.05g, and then add 5mL of deionized water to dissolve evenly, pour this solution into a silica gel sheet mold, and irradiate with 4000 watts of strong ultraviolet light for 3s to obtain a single network gel. Weigh 0.4g of acrylic acid, 0.008g of crosslinking agent N,N'-methylenebismethacrylamide, 0.36g of initiator 2,4,6(trimethylbenzoyl)diphenylphosphine oxide, add 40mL Deionized water, mixed evenly, put the single-network gel in this solution until the swelling is balanced, take it out, and irradiate it with 100 watts of weak ultraviolet light for 0.5h to obtain a high-strength double-network hydrogel. The hydrogel can absorb water 15 times its own weight, has a tensile strength of 0.35 MPa, a breaking elongation of 230%, a compressive strength of 10 MPa, an...

Embodiment 3

[0048] Take by weighing 2.5g of 2-acrylamide-2-methylpropanesulfonic acid, crosslinking agent N, N'-methylenebisacrylamide 0.001g, initiator α-ketoglutaric acid 0.0025g, polyoxyethylene (molecular weight 500000) 0.25g, then add 5mL deionized water, dissolve evenly, pour this solution into a silicone sheet mold, and irradiate with 2000 watts of strong ultraviolet light for 300s to obtain a single network gel. Weigh 2.5g of acrylamide, 0.35g of cross-linking agent N,N'-methylenebisacrylamide, 0.0045g of initiator α-ketoglutaric acid, add 50mL of deionized water, and mix evenly. In this solution, until the swelling is balanced, take it out, and irradiate it with weak ultraviolet light at 100 watts for 5 hours to obtain a high-strength double-network hydrogel. The hydrogel can absorb water 10 times its own weight, has a tensile strength of 0.35 MPa, a breaking elongation of 200%, a compressive strength of 12 MPa, and a compressive deformation rate of over 95%.

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Abstract

The invention relates to a preparation method of hydrogel and aims at providing a preparation method of novel double-network hydrogel with high water absorption and high strength. The preparation method comprises the following steps: firstly, a first network monomer, a cross-linking agent, a dispersion medium and an initiator are dissolved in water, and a solution is poured into a silica gel sheet mould, irradiated under strong ultraviolet radiation, stood and cooled; gel is taken out of the mould, put into a water solution containing a second network monomer, a cross-linking agent and an initiator, swollen until balancing, and then taken out to carry out weak ultraviolet radiation so as to obtain the double-network hydrogel with high water absorption and high strength. The invention has simple preparation process and can quickly obtain the double-network hydrogel with superior performance and high water absorptivity. The hydrogel has very good water absorbing capacity and superior mechanical property and can bear external force well. The hydrogel can be widely applied to the field of biomedicine comprising medicine wrapping, medicine slow-controlled release, artificial eye cornea, burn protective films and articular cartilage restoration and replacement and also has potential application value in the field of the light industry.

Description

technical field [0001] The invention relates to a preparation method of a hydrogel, in particular to a preparation method of a novel high water-absorbing, high-strength double-network hydrogel. Background technique [0002] Due to its good biocompatibility and environmental friendliness, hydrogel can be widely used in the field of biomedicine, including drug packaging, drug slow (controlled) release, artificial cornea, burn protective film, and articular cartilage. Recently, a hydrogel with a bilayer network structure has attracted extensive attention due to its favorable mechanical properties, coefficient of friction, and elastic modulus. The double network hydrogel is a hydrogel combined with two independent hydrophilic polymer cross-linked networks. [0003] For the preparation of double-network hydrogels, many methods have been reported in patents and literature, including the following: [0004] (1) With 2-acrylamide-2-methylpropanesulfonic acid as the first monomer, ...

Claims

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Application Information

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IPC IPC(8): C08F220/58C08F220/56C08F220/06C08F220/34C08F220/36C08F2/48A61K47/32A61L27/26A61L27/52A61L27/56A61L31/04A61L31/14
Inventor 单国荣田帅王露一
Owner ZHEJIANG UNIV
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