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Application of aldehyde-modified polysaccharide containing carboxyl to preparing medicine and medical material

A technology for modifying aldehydes and polysaccharides, which is applied in the application field of aldehyde-modified polysaccharides in the preparation of medicines and medical materials, to achieve the effects of inhibiting bacterial growth, increasing biocompatibility, and inhibiting tumor cell growth

Active Publication Date: 2010-01-27
OCEAN UNIV OF CHINA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Therefore, the application of aldehyde-modified polysaccharides containing only aldehyde groups in medical materials is still insufficient.

Method used

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  • Application of aldehyde-modified polysaccharide containing carboxyl to preparing medicine and medical material
  • Application of aldehyde-modified polysaccharide containing carboxyl to preparing medicine and medical material

Examples

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Effect test

Embodiment 1

[0008] Embodiment 1 Preparation of aldehyde-modified polysaccharide containing carboxyl groups and its application in hemostasis and wound healing:

[0009] In the 2% (weight percent concentration, the same below) sodium alginate aqueous solution that is 1000ml in volume, add 5% sodium periodate aqueous solution according to the molar ratio of sodium alginate and sodium periodate as 2:1 , stirred and reacted at room temperature for 24 hours in the dark, added 5ml of ethylene glycol to terminate the oxidation reaction for 0.5 hours, precipitated the reaction product with ethanol, filtered it with suction, dehydrated it with absolute ethanol, obtained a white solid by suction filtration, and dried it in vacuum at room temperature to obtain a product containing Carboxyl aldehyde-modified sodium alginate, the molar ratio of the aldehyde group in the carboxyl-containing aldehyde-modified sodium alginate molecule to the sugar residue in sodium alginate is 0.7:1, and the sodium carbox...

Embodiment 2

[0014] Embodiment 2 contains the application of the aldehyde-modified polysaccharide of carboxyl group in antibacterial:

[0015] (1) According to the method described in the preparation (appendix 89-appendix 90) of the culture medium under the appendix XI H sterility test method of "The Pharmacopoeia of the People's Republic of China" version two (National Pharmacopoeia Commission edited), prepared in proportion 200ml of nutrient agar medium was placed in a 500ml Erlenmeyer flask with a cotton plug. According to this method again, no agar is added, other ingredients are added in proportion, 50ml of nutrient liquid medium is prepared, placed in a 250ml triangular flask with a cotton plug, marked as 1# bottle; no agar is added, 0.5g of carboxyl-containing Aldehyde-modified sodium alginate and other ingredients were added in proportion to prepare 50ml of carboxyl-containing aldehyde-modified polysaccharide nutrient liquid medium, which was placed in another 250ml triangular flas...

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Abstract

The invention relates to application of aldehyde-modified polysaccharide containing carboxyl to preparing medicines and medical materials for stanching, healing wound, inhibiting bacteria, resisting tumor, promoting tissue adhesion or wound closure. The aldehyde-modified polysaccharide molecule containing carboxyl contains aldehyde groups and carboxyl salt. The aldehyde-modified polysaccharide containing carboxyl contains the aldehyde group in the molecule, thus increasing reactivity of the polysaccharide, inhibiting growth of bacteria, inhibiting growth of tumor cells, having the effects of stanching and promoting tissue adhesion and wound closure, the polysaccharide can be used as a drug carrier material, and the aldehyde group also increases biodegradability of the aldehyde-modified polysaccharide; and the carboxyl salt in the molecule increases hydrophilicity and biocompatibility of the aldehyde-modified polysaccharide, and local acidity is not formed during degradation and absorption in human body, which can increase biocompatibility of the human body, so the aldehyde-modified polysaccharide is applicable to the body surface and the body interior.

Description

technical field [0001] The invention relates to an aldehyde-modified polysaccharide, in particular to the application of an aldehyde-modified polysaccharide containing carboxyl groups in the preparation of medicines and medical materials. Background technique [0002] Due to the advantages of non-immunogenicity, biodegradability, and good biological safety, polysaccharides have been widely reported in the field of biological and medical technology. For example, starch and cellulose are used as drug excipients, medical gauze and absorbent cotton are prepared from cellulose, and chitosan and chitosan derivatives are used to prepare tissue engineering scaffold materials. However, the types of polysaccharides are different, their water solubility is different, their biodegradability is different, and their biological functions are also different. At present, there have been many reports on the modification of polysaccharides, such as modifying chitosan to water-soluble carboxym...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/715A61K31/717A61K31/718A61K31/716A61K31/722A61K31/728A61K31/734A61L15/28A61L15/46A61L15/42A61L27/20A61L27/54A61L27/58A61P7/04A61P17/02A61P31/00A61P35/00
Inventor 韩宝芹刘万顺常菁董文
Owner OCEAN UNIV OF CHINA
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