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Gentamycin sulfate tablets and preparation method thereof

A technology of gentamicin sulfate and gentamicin tablets, which is applied in the direction of pharmaceutical formulations, medical preparations containing no active ingredients, medical preparations containing active ingredients, etc., can solve problems such as poor compressibility, and achieve improved release The ability of drugs, improving the solubility in the stomach, and the effect of product quality assurance

Active Publication Date: 2010-03-10
YUNNAN PHYTOPHARML
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Starch is used alone as diluent in the original recipe, which has poor compressibility

Method used

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  • Gentamycin sulfate tablets and preparation method thereof
  • Gentamycin sulfate tablets and preparation method thereof
  • Gentamycin sulfate tablets and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] The pharmaceutical formula consists of: 750g of gentamicin sulfate, 2000g of auxiliary materials, and the mass percentage of auxiliary materials is: 40% of starch, 10% of microcrystalline cellulose, 30% of calcium sulfate, 10% of PEG6000, and 10% of magnesium stearate.

[0040] Preparation:

[0041] (1) Take starch, microcrystalline cellulose, calcium sulfate, PEG6000, magnesium stearate by weighing according to formula quantity, pass through 80 mesh sieves respectively;

[0042] (2) starch, microcrystalline cellulose, calcium sulfate and gentamycin sulfate raw materials are mixed;

[0043] (3) Dissolving PEG6000 in 95% ethanol solution to prepare and use a concentration of 5% as an adhesive to make soft materials and granulate;

[0044] (4) Dry the wet granules at a temperature of 55° C., size the granules, add magnesium stearate and mix evenly, measure the moisture content of the dry granules with a rapid moisture analyzer, and control the moisture content of the dry...

Embodiment 2

[0046] The pharmaceutical formula consists of: 750g of gentamicin sulfate, 2000g of auxiliary materials, and the mass percentage of auxiliary materials is: starch 55%, microcrystalline cellulose 7%, calcium sulfate 20%, PEG6000 is 5%, silicon dioxide 8%, stearic acid Magnesium 5%.

[0047] Preparation:

[0048] (1) Weigh starch, microcrystalline cellulose, calcium sulfate, PEG6000, and silicon dioxide according to the formula, and pass through a 80-mesh sieve respectively;

[0049] (2) starch, microcrystalline cellulose, calcium sulfate and gentamycin sulfate raw materials are mixed;

[0050] (3) Dissolving PEG6000 in 85% ethanol solution to prepare and use a concentration of 10% as an adhesive to make soft materials and granulate;

[0051] (4) Dry the wet granules at a temperature of 65°C, granulate, add silicon dioxide and magnesium stearate and mix evenly, measure the moisture content of the dry granules with a rapid moisture analyzer, and control the moisture content of ...

Embodiment 3

[0053] The pharmaceutical formula consists of: 750g of gentamicin sulfate, 2000g of auxiliary materials, and the mass percentage of auxiliary materials is: 70% of starch, 1% of microcrystalline cellulose, 10% of calcium sulfate, 1% of PEG6000, and 18% of talcum powder.

[0054] Preparation:

[0055] (1) Take starch, microcrystalline cellulose, calcium sulfate, PEG6000, and talcum powder according to the formula, and pass through a 80-mesh sieve respectively;

[0056] (2) starch, microcrystalline cellulose, calcium sulfate and gentamycin sulfate raw materials are mixed;

[0057] (3) Dissolving PEG6000 in 75% ethanol solution to prepare and use a concentration of 15% as an adhesive to make soft materials and granulate;

[0058] (4) Dry the wet granules at a temperature of 80° C., size the granules, add talcum powder and mix evenly, measure the moisture content of the dry granules with a rapid moisture analyzer, and control the moisture content of the dry granules at 6.0% for ta...

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Abstract

The invention provides gentamycin sulfate tablets and a preparation method thereof. The stability of the gentamycin sulfate tablets is effectively increased by altering the auxiliary formula of the original production process and the quality problem that the gentamycin sulfate tablets are easy to crack during storage is solved. The auxiliary formula of production technology comprises the following components by weight percent: 40-70% of starch, 1-10% of microcrystalline cellulose, 10-30% of calcium sulfate and 1-10% of PEG6000. In the product, the water content of particles is reduced and controlled to 1.0-6.0%, and the drying temperature of the original process is reduced and controlled to 55-80 DEG C. The prepared gentamycin sulfate tablets of the invention have smooth surface of tablets and stable performance, the product is applicable to mass production, and the product quality meets the requirements of the China Pharmacopeia.

Description

technical field [0001] The present invention relates to a kind of preparation technology of medicine, specifically a kind of gentamicin sulfate tablet and preparation method. Background technique [0002] Gentamycin Sulfate (Gentamycin Sulfate) is an aminoglycoside broad-spectrum antibiotic, has good antibacterial effect on various Gram-negative bacteria and Gram-positive bacteria, and has good antibacterial effect on various Enterobacteriaceae bacteria such as Escherichia coli, Klebsiella It has a good antibacterial effect on the genus Burdella, Proteus, Salmonella, Shigella, Enterobacter, Serratia and Pseudomonas aeruginosa. Neisseria and Haemophilus influenzae are moderately sensitive to it. It also has certain effects on Brucella, Yersinia pestis, Acinetobacter, and Campylobacter fetus. And it has a good antibacterial effect on about 80% of methicillin-sensitive strains in Staphylococcus (including Staphylococcus aureus and coagulase-negative staphylococcus). The mecha...

Claims

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Application Information

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IPC IPC(8): A61K9/20A61K31/7036A61K47/38A61K47/36A61K47/34A61K47/02A61P31/04A61K47/10
Inventor 郭文叶亚斌李云仙宋丽
Owner YUNNAN PHYTOPHARML
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