Pharmaceutical plaster substrate, preparation method and applications thereof

Abstract

The invention discloses a pharmaceutical plaster substrate, a preparation method and applications thereof. The pharmaceutical plaster substrate comprises the following components by weight parts: 15 to 65 parts of natural rubber, 5 to 45 parts of viscosifier, 0 to 20 parts of softener and 15 to 70 parts of filling agent. The invention overcomes the defects that the traditional natural rubber plaster has little adhesion, large difference, low smoothness and the like, solves the technical difficulty that the existing preparation technology has poor controllability and instability, has the advantages of smooth production processing, good coating effect, good smoothness of plaster surface (fineness and no blank spot), excellent pasting performance, good stability, proper peeling, strong permeation force, long maintaining time of drug efficacy and drug effect, large drug loading quantity and safe use and the like.

Description

technical field [0001] The invention relates to a medicinal plaster matrix and a preparation method thereof, and also relates to the application of the medicinal plaster matrix in preparing medicinal plasters, which belongs to the field of traditional Chinese medicine preparations. Background technique [0002] Plaster is one of the five traditional dosage forms in my country. This type of preparation avoids the liver first-pass effect that may occur after oral administration and improves bioavailability; it can produce long-lasting, constant and controllable blood drug concentration, which enhances the therapeutic effect. As a result, the side effects of gastrointestinal administration are reduced; the action time can be prolonged, and the frequency and dose of medication can be reduced; patients can use the medicine by themselves, which is convenient to use and can avoid pain during injection. In recent years, the applicable population and applicable diseases of plasters ha...

AI Technical Summary

Problems solved by technology

Traditional Chinese medicine rubber plaster overcomes the shortcomings of traditional black plasters such as inconvenient use and easy contamination of clothes

However, the production of rubber paste generally adopts the solvent method, and a large amount of solvent—gasoline is used in the production process, which is flammable and explosive, has poor safety, high production cost, and the residue of gasoline causes skin allergies, and the production process needs to be dried for a long time. , recovery of gasoline, resulting in loss of volatile components

The hot pressing method overcomes the shortcomings of the solvent method rubber paste, does not need gasoline, is safe in production, meets environmental protection requirements, has low production costs, and has a lower skin allergy rate than the solvent method. The properties and smoothness are not as good as those of the solvent method. Therefore, in order to solve the technical problems in the large-scale production and preparation of rubber-based traditional Chinese medicine plasters, it is necessary to develop a medicinal plaster matrix that can be produced by hot pressing. The prepared product has excellent properties. Adhesive properties, uniformity and good smoothness

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