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Purslane seed polysaccharide granule preparation and preparation method thereof

A technology of purslane seed and granule preparation is applied in the directions of anti-inflammatory agents, pharmaceutical formulations, non-central analgesics, etc., which can solve the problems of poor curative effect and low utilization rate of active ingredients, achieve low cost, promote wound healing, The effect of good application prospects

Inactive Publication Date: 2010-05-05
秦大伟
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The preparation has the effects of antibacterial, blood lipid lowering, muscle relaxation, anti-inflammation, and wound healing promotion, and also has strong anti-aging and anti-oxidation effects, which solves the problems of low utilization rate of active ingredients and poor curative effect of purslane traditional Chinese medicine. Has a good application prospect

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Take 2 kg of purslane coarse powder, add 18 kg of distilled water, decoct 3 times, 2 hours each time, filter, combine the extracts, concentrate, cool and centrifuge for 15 minutes, take the supernatant, and adjust the final concentration with absolute ethanol to 75%, standing overnight at 4°C to obtain a precipitate, which was reflux washed with absolute ethanol, acetone, and ether to obtain off-white purslane polysaccharide powder.

[0029] Take 100g of the above-mentioned purslane polysaccharide, 200g of hydroxypropyl methylcellulose, and 150g of microcrystalline cellulose, mix them uniformly and pass through a 100-mesh sieve, add 20g of 1-5% ethanol solution of ethylcellulose, and dry at 60°C for 5 hour, then pass through a 20-mesh sieve for granulation, add 4g of micropowder silica gel, mix evenly, and press into tablets to obtain the purslane polysaccharide granule preparation.

Embodiment 2

[0031] Take 2 kg of purslane coarse powder, add 18 kg of distilled water, decoct 3 times, 2 hours each time, filter, combine the extracts, concentrate, cool and centrifuge for 15 minutes, take the supernatant, and adjust the final concentration with absolute ethanol to 75%, standing overnight at 4°C to obtain a precipitate, which was reflux washed with absolute ethanol, acetone, and ether to obtain off-white purslane polysaccharide powder.

[0032] Take 100g of the above purslane polysaccharide, 200g of ethyl cellulose, 150g of lactose, mix well and pass through a 100 mesh sieve, add 20g of 1-5% ethanol solution of ethyl cellulose, dry at 60°C for 5 hours, then pass through 20 Mesh sieve for granulation, add 4g of magnesium stearate, mix well, and press into tablets to obtain the purslane polysaccharide granule preparation.

Embodiment 3

[0034] Take 2 kg of purslane coarse powder, add 18 kg of distilled water, decoct 3 times, 2 hours each time, filter, combine the extracts, concentrate, cool and centrifuge for 15 minutes, take the supernatant, and adjust the final concentration with absolute ethanol to 75%, standing overnight at 4°C to obtain a precipitate, which was reflux washed with absolute ethanol, acetone, and ether to obtain off-white purslane polysaccharide powder.

[0035] Take 100g of the above-mentioned purslane polysaccharide, 200g of cellulose acetate, and 150g of mannitol, mix them evenly and pass through a 100-mesh sieve, add 20g of 5-15% ethanol solution of polyvinylpyrrolidone, dry at 60°C for 5 hours, and then pass through a 20-mesh sieve Sieve the granules, add 4g of talcum powder, mix well, and press into tablets to obtain the purslane polysaccharide granule preparation.

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Abstract

The invention relates to a purslane seed polysaccharide granule preparation and a preparation method thereof. In the preparation, purslane seed polysaccharide is used an active ingredient matched with other officinal auxiliary materials which comprise slow-release material, a bulking agent, a bonding agent, a lubricant and the like. The preparation has both the functions of anti-bacteria, anti-hyperlipidemia, muscle relaxation, anti-inflammation and wound healing promotion and the functions of anti-aging and anti-oxidation, solves the problems of low utilization ratio of effective constituents of purslane seed as a traditional Chinese medicine and poor curative effect; therefore, the preparation has better application prospect.

Description

Technical field: [0001] The invention relates to a purslane polysaccharide granule preparation, which belongs to a granule preparation made from extracts of Chinese medicinal materials and pharmaceutical auxiliary materials. Background technique: [0002] Purslane (Portul aca oleracea L) belongs to Portulacaceae (Portulacaceae), an annual succulent herb, is an ancient vegetable and medicinal plant in my country, and is distributed in most parts of China, also known as longevity vegetable, five elements grass, Melon seed vegetables, hemp rope vegetables, five-color amaranth, horse food vegetables, etc. Purslane, with its rich nutrition, unique pharmacological effects, and dual-use characteristics of vegetables and medicines, has long been widely used by the people to treat diseases such as heat-toxin bloody dysentery, carbuncle, boils, snake bites, and blood in the stool, and has become increasingly popular. Research. Modern scientific research also shows that purslane conta...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/185A61K9/16A61K47/38A61K47/40A61P1/04A61P1/16A61P15/00A61P13/02A61P25/04A61P29/00A61P31/04A61K131/00
Inventor 秦大伟王利振
Owner 秦大伟
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