Method for preparing silicon dioxide magnetic composite microballoon with core-shell structure

A technology of magnetic composite microspheres and silicon dioxide, which is applied in the fields of magnetism of inorganic materials, manufacture of inductors/transformers/magnets, electrical components, etc., can solve problems such as difficulty in particle size control, unfavorable biological applications, rough surface of microspheres, etc., to achieve Ease of cleaning, controllable shell thickness, and narrow particle size distribution

Active Publication Date: 2010-05-12
XIAN GOLDMAG NANOBIOTECH
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  • Abstract
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Problems solved by technology

[0004] In order to solve the preparation method of silica magnetic composite microspheres with a core-shell structure described in the background technology, the operation is cumbersome, the particle size is difficult to control, the surface of the prepared microspheres is rough, and the core agglomeration phenomenon is serious, which is not conducive to downstream biological applications. Technical problem, the present invention provides a preparation of silica magnetic c

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  • Method for preparing silicon dioxide magnetic composite microballoon with core-shell structure
  • Method for preparing silicon dioxide magnetic composite microballoon with core-shell structure
  • Method for preparing silicon dioxide magnetic composite microballoon with core-shell structure

Examples

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Embodiment 1

[0027] Example 1: Preparation of silica magnetic composite microspheres with a particle diameter of 50 nm and a core-shell structure.

[0028] 15 mg of iron oxide nanoparticles with a particle diameter of 8 nm monodispersed in water were added to the mixed solution of ethanol and water with a volume ratio of 1:1, and stirred for 0.3 h at a stirring speed of 300 rpm. Add 0.02ml tetraethyl orthosilicate to the above solution, stir for 2h at a stirring speed of 400rpm, then add 0.5mL concentrated ammonia water, and continue stirring for 24h. The silica magnetic composite microspheres with a core-shell structure are separated from the solution by an external magnetic field, the supernatant is discarded, the silica magnetic composite microspheres are washed with ultrapure water and absolute ethanol, and dispersed in water. The silica magnetic composite microspheres with a core-shell structure with a particle size of 50nm were obtained, and the electron microscope characterization o...

Embodiment 2

[0029] Example 2: Preparation of silica magnetic composite microspheres with a particle diameter of 80 nm and a core-shell structure.

[0030] 15 mg of iron oxide nanoparticles with a particle size of 10 nm monodispersed in water were added to a mixed solution of isopropanol and water (volume ratio 1:5), and stirred for 0.3 h at a stirring speed of 300 rpm. Add 0.5ml tetraethyl orthosilicate to the above solution, stir for 2h at a stirring speed of 400rpm, then add 2.5mL of concentrated ammonia water, continue stirring for 12h, and use an external magnetic field to remove the silica magnetic composite microspheres with a core-shell structure from the solution The supernatant was discarded, the silica magnetic composite microspheres were washed with ultrapure water and absolute ethanol, and dispersed in water. The silica magnetic composite microspheres with a core-shell structure with a particle size of 80nm are obtained, and the electron microscope characterization of the micr...

Embodiment 3

[0031] Example 3: Preparation of silica magnetic composite microspheres with a particle diameter of 100 nm and a core-shell structure.

[0032]Add 15 mg of iron oxide nanoparticles with a particle size of 12 nm monodisperse in water to a mixed solution of ethanol and water (volume ratio 1:3), then add 0.5 g of PVP10K, stir for 0.5 h, and the stirring speed is 300 rpm . Add 1 ml of methyl orthosilicate to the above solution, stir for 2 h at a stirring speed of 600 rpm, then add 3 mL of concentrated ammonia water, and continue stirring for 4 h to prepare silica magnetic composite microspheres with a core-shell structure. The silica magnetic composite microspheres with a core-shell structure are separated from the solution by an external magnetic field, the supernatant is discarded, the silica magnetic composite microspheres are washed with ultrapure water and absolute ethanol, and dispersed in water. The electron microscope characterization of the microspheres is shown in the a...

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Abstract

The invention belongs to the field of the synthesis of magnetic nano materials, and relates to a method for preparing a silicon dioxide magnetic composite microballoon with a core-shell structure. The method comprises the following steps: adding magnetic iron oxide nano particles monodispersed in water into the mixing solution of alcohol and ultrapure water, and stirring for 0.3-2h; then adding 0.01-1ml of tetraethyl silicate in the mixture, and stirring for 0.3-2h; then adding 0.5-5ml of stronger ammonia water, continuing to stir for 2-24h, and obtaining the solution of the silicon dioxide magnetic composite microballoon with the core-shell structure; and using applied magnetic field for separating the microballon from the solution. In the invention, by proportioning the quantity of the reactant reasonably, and setting the reaction conditions reasonably, one or a plurality of the iron oxide magnetic nano particle(s) are covered in each produced silicon dioxide microballoon, and the microballoon has good balling performance and monodispersity, has controllable shell layer thickness and narrow particle size distribution, and is easy to clean, simple and convenient in operation, low in cost, less in waste, and high in productivity.

Description

technical field [0001] The invention belongs to the field of synthesis of magnetic nanometer materials, and relates to a method for preparing silicon dioxide magnetic composite microspheres with a core-shell structure. Background technique [0002] Magnetic nanoparticles have some special magnetic properties, such as: superparamagnetism, high saturation magnetization, etc., and have broad application prospects in biomedical fields such as targeted drug carriers, cell separation, nuclear magnetic resonance, immune detection, and biomolecular purification. . In recent years, core-shell composite materials with magnetic nanoparticles as the core and silica as the shell have attracted widespread attention. This is because silica has good biocompatibility and anti-decomposition ability. After the surface of nanoparticles is coated with a layer of silica, it can greatly shield the interaction of magnetic dipoles, so that the particles have good water dispersibility, chemical stab...

Claims

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Application Information

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IPC IPC(8): H01F1/03H01F41/02
Inventor 彭明丽李雅丽陈超崔亚丽王苗张彩权
Owner XIAN GOLDMAG NANOBIOTECH
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