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Absorbable magnesium alloy stent of anticorrosion and drug release composite coating and preparation method thereof

A magnesium alloy stent and composite coating technology, which is applied in the directions of drug devices, stents, coatings, etc., can solve the problems of fast degradation and no drug-carrying coating, and improve corrosion resistance and surface biocompatibility. The effect of improving the anti-corrosion effect

Inactive Publication Date: 2010-06-09
TIANJIN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

But the stent degrades too quickly in the body and has no drug-loaded coating

Method used

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  • Absorbable magnesium alloy stent of anticorrosion and drug release composite coating and preparation method thereof
  • Absorbable magnesium alloy stent of anticorrosion and drug release composite coating and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Magnesium alloy WE42 was engraved into a stent with a laser, and then placed in a solution containing 7% HCl and 8% FeCl 2 In the pickling solution, the power is 500W ultrasonic treatment for 30 minutes, and then it is placed in a vacuum furnace for annealing treatment, the temperature is raised to 1100°C at a rate of 3°C / min, and after being kept for 30 minutes, it is then heated at a rate of 4°C / min After the speed was lowered to 20°C, the ultrasonic cleaner with a power of 500W was used to ultrasonically clean in deionized water for 15 minutes and then dried. The magnesium alloy organic-inorganic composite coating on the surface of the cell experiment had good biocompatibility, and the degradation products were non-toxic.

[0025]An inorganic anti-corrosion coating was prepared on the dried scaffold. The micro-arc oxidation method is adopted, and the electrolyte composition is NaOH 1-200g / L, NaOH 2 SiO 3 1-200g / L, the oxidation time is 10-200min (such as 10, 20, 4...

Embodiment 2

[0031] The experimental conditions and operating process are the same as in Example 1, except that the oxidation current is changed to 0.01-2A / cm in the process of preparing the micro-arc oxidation inorganic coating 2 , Cell experiments show that the magnesium alloy organic-inorganic composite coating has good biocompatibility, the degradation products are non-toxic, and the film thickness is 10-60 μm.

[0032] The prepared stent was tested in Hank's artificial simulated body fluid at 37°C, and the results showed that the corrosion resistance of the magnesium alloy stent after the micro-arc oxidation film was sealed by the cross-linked gelatin / PLGA drug-loaded nanosphere composite film was much higher than that of the unsealed Corrosion resistance of magnesium alloy stents treated with inorganic coatings, changing the current parameters can change the corrosion resistance of magnesium alloys, the corrosion resistance of the micro-arc oxidation current density is 30 times the co...

Embodiment 3

[0034] The experimental conditions and operation process are similar to those of Examples 1 and 2, except that the cross-linked gelatin cross-linking method is changed in the process of preparing the magnesium alloy stent after the cross-linked gelatin / PLGA drug-loaded nano-microsphere composite film is sealed with the micro-arc oxidation film. The magnesium alloy organic-inorganic composite coating on the surface of the cell experiment has good biocompatibility, the degradation products are non-toxic, and the thickness of the film layer is 20-30 μm.

[0035] The prepared stents were tested in artificial simulated body fluid at 37°C. The results showed that the degradation cycles of the magnesium alloy stents after the micro-arc oxidation film was sealed by the cross-linked gelatin / PLGA drug-loaded nanosphere composite film with different degrees of gelatin cross-linking were different. The polymer coating degrades within 100-150 days, and the metal stent degrades within 240-42...

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Abstract

The invention relates to an absorbable magnesium alloy stent of anticorrosion and drug release composite coating and a preparation method thereof. The absorbable magnesium alloy stent comprises a magnesium alloy stent skeleton and composite coating, wherein the surface layer of the magnesium alloy stent skeleton is an inorganic anti-corrosion coating, the outside of the inorganic anti-corrosion coating is provided with organic sealing and drug release composite coating; and the inorganic anti-corrosion coating is dense coating with metallurgical structure composed of MgSiO3, MgO and SiO2 with zeolite structure. The inorganic anti-corrosion coating is prepared on the surface of a matrix through microarc oxidation, and the sealing and drug release composite coating composed of crosslinked gelatin / PLGA medicine-carried nanospheres blend film is prepared outside the anti-corrosion coating. The absorbable magnesium alloy stent of the invention effectively controls the corrosivity of the magnesium alloy stent, the organic coating has double functions, the use of the sealing inorganic coating increases the corrosion resistance, controls the drug to release, and reduces the burst effect of the drug to ensure that the drug is released in a certain concentration continuously and slowly. Meanwhile, each coating can be biodegraded and the degradation product is non-toxic, thus effectively improving the biocompatibility and blood compatibility of the magnesium alloy surface.

Description

technical field [0001] The invention relates to an absorbable magnesium alloy stent with an anti-corrosion and drug slow-release composite coating and a preparation method. Background technique [0002] In 1964, Dotter et al proposed the concept of percutaneous transluminal angioplasty, and proposed to use silicone rubber or plastic to support the blood vessel to keep the blood flow in the blood vessel smooth [4] , in 1969, they used metal rings to make vascular stents in animals for the first time [5] . Sigwart successfully implemented the first coronary stent in 1987. Afterwards, cardiovascular stents were widely accepted as the second milestone in the history of interventional therapy for coronary heart disease. By the beginning of the 21st century, the clinical application of drug-eluting stents represented by Cypher and TAXUS was hailed as the third milestone. [0003] Intracoronary stent implantation has significantly reduced the restenosis rate from 30% to 60% in ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61F2/82A61L27/32A61L27/34A61L27/54A61L27/04A61M31/00
Inventor 许鑫华逯平
Owner TIANJIN UNIV
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