Construction method of medical titanium alloy implant surface growth factor delivery system

A technology of surface growth and construction method, used in medical science, prosthesis and other directions, can solve the problems of unsatisfactory sintering strength, difficult to guarantee bonding strength, etc., achieve strong and reliable adhesion, meet strong adhesion, coating preparation simple craftsmanship

Inactive Publication Date: 2010-08-04
FOURTH MILITARY MEDICAL UNIVERSITY
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Problems solved by technology

However, on the one hand, there are still defects in the sintering process of titanium beads, and the sintering strength cannot meet the requirements. On the other hand, as a polypeptide, the bonding strength of RGD to the surface of inorganic metal materials is always difficult to guarantee.

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  • Construction method of medical titanium alloy implant surface growth factor delivery system
  • Construction method of medical titanium alloy implant surface growth factor delivery system
  • Construction method of medical titanium alloy implant surface growth factor delivery system

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Embodiment Construction

[0010] The present invention will be described in further detail below in conjunction with the accompanying drawings and embodiments. However, the present invention is not limited to the following examples.

[0011] According to previous studies, the surface of microgrooves and ridges is more suitable for the adhesion and growth of osteoblasts than the smooth surface and irregular frosted surface (see Figure 1, 2), and its preparation process is simple, the quality is easy to control, and it is more suitable for industrial production. Related research results have been published (Jun Fu, Zheng Guo, Yunyu Hu, Yongquan Zhang, Yulin Hao, Shujun Li. Effect of surface micro-topography of titanium material on the behaviors of rabbit osteoblast in vitro. Applied Surface Science. 2008; 255: 286 -289). Therefore, this application adopts the surface of micro-grooves and ridges to replace the previous sintered surface of titanium beads to overcome the problems of insufficient sintering ...

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Abstract

The invention relates to a construction method of a medical titanium alloy implant surface growth factor delivery system, which comprises the following steps that: micro-groove ridges are prepared on the surface of a medical low-elastic Beta titanium alloy; gelatin is dissolved into deionized water, and then 2-imine hydrogen chloride mercaptan is added to be dialyzed and dried, to prepare SH gelatin; the SH gelatin is dissolved in double-distilled water to be ultrasonically homogenized to prepare B liquid, emulsifier is added into liquid paraffin, and then the B liquid is dripped into the liquid paraffin which is added with the emulsifier, isopropyl alcohol and ether are cleaned, added with glutaraldehyde and cured, ether elutes, dries and sieves out the cured substance, and 60Co irradiates and sterilizes, to prepare SH gelatin microspheres; and the microspheres are soaked into rhBMP2 guanidine hydrochloride saturated solution and freeze dried under a vacuum condition, to prepare the SH gelatin microspheres loaded with growth factors. Medical low-elastic Beta titanium alloy implant material is soaked into dopamine solution, and a layer of adhered polymer thin film is generated on the surface of the titanium alloy; and the implant material which decorates the surface is put into the growth factor SH gelatin microsphere solution, vacuum is pumped, and the medical titanium alloy implant surface growth factor delivery system is prepared.

Description

technical field [0001] The invention relates to a preparation method of a medical osteoinductive metal implant material, in particular to a construction method of a growth factor slow-release system on the surface of a medical titanium alloy implant. Background technique [0002] A good bioactive surface with osteoinductive ability has always been a difficult problem for metal material implants. At present, there are many ways to modify the surface activity of metal materials, but so far, the clinical applications are limited to porous surfaces and calcium phosphate coatings, which is still far from the ideal bioactive surface. In order to make the metal implant material have a good bioactive surface, the inventors conducted a series of studies. In the early research, RGD was used to modify the microporous surface of the material, and then the method of compounding drug-loaded microspheres to RGD was used to construct a growth factor sustained-release system on the surface ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/54A61L27/06
Inventor 郭征郝玉琳吴红李小康
Owner FOURTH MILITARY MEDICAL UNIVERSITY
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