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Biomedical material with silver-ion-bearing hydroxyapatite coating and preparation method thereof

A technology of biomedical materials and hydroxyapatite, which is applied in the field of surface modification of biomedical materials, can solve the problems of unfavorable release of antibacterial materials and uneven distribution of antibacterial materials, so as to achieve good antibacterial effect, reduce costs, and achieve good results. The effect of uniformity

Inactive Publication Date: 2010-08-11
SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The technical problem to be solved by the present invention is that the bacteriostatic material cannot be evenly distributed in the existing antibacterial hydroxyapatite bioactive coating material due to the density difference between the bacteriostatic material and the solid powder raw material, and the existing powder The high temperature of plasma spraying leads to the pyrolysis of antibacterial materials and the surface of hydroxyapatite sprayed by powder plasma is very dense, which is not conducive to the release of antibacterial materials.

Method used

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  • Biomedical material with silver-ion-bearing hydroxyapatite coating and preparation method thereof
  • Biomedical material with silver-ion-bearing hydroxyapatite coating and preparation method thereof
  • Biomedical material with silver-ion-bearing hydroxyapatite coating and preparation method thereof

Examples

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preparation example Construction

[0039] (1) Preparation of hydroxyapatite suspension

[0040] According to the calcium-phosphorus molar ratio of 1.67, prepare an aqueous solution of calcium nitrate with a molar concentration of 0.5-2.5 mol / L and an aqueous solution of diammonium hydrogen phosphate with a molar concentration of 0.5-3 mol / L; The aqueous solution is added dropwise to the calcium nitrate aqueous solution at a rate of 5-15ml / min for reaction, and then ammonia water with a percentage concentration of 10%-30% is added dropwise to the reaction solution at a rate of 1-10ml / min, and the pH of the reaction solution is controlled to be 9-12, keep the reaction temperature at 30-90°C, after the complete reaction, let stand for 5-15 minutes, and then age for 24-48 hours to prepare the hydroxyapatite suspension for use;

[0041] (2) Loading of antibacterial materials

[0042] A certain amount of antibacterial material is added to the hydroxyapatite suspension under constant stirring, and the mass ratio of t...

Embodiment 1

[0047] Example 1 Preparation of Hydroxyapatite Bioactive Coating by Powder Plasma Spraying

[0048] In this example, hydroxyapatite powder is used as the raw material for spraying. Use atmospheric plasma spraying equipment (Sulzer Metco MNspray system and AR2000 robot arm) to spray a layer of HA coating on the surface of the substrate, the coating thickness is 100 microns, the spraying power is 24 kW, the spraying distance is 100 mm, and the hydroxyapatite powder is directly injected In the central area of ​​the plasma flame, a coating is finally formed on the titanium alloy substrate. The surface morphology of the coating is observed with a scanning electron microscope. The scanning electron microscope photo is shown in figure 1 (a). For the antibacterial properties of its coating, see figure 2 .

Embodiment 2

[0049] Embodiment two liquid phase ion spraying hydroxyapatite bioactive coating

[0050] First, prepare the hydroxyapatite suspension as the raw material for spraying. According to the molar ratio of calcium to phosphorus of 1.67, configure an aqueous solution of calcium nitrate with a molar concentration of 1.6mol / L and an aqueous solution of diammonium hydrogen phosphate with a molar concentration of 2.5mol / L; under continuous and sufficient stirring , the above-mentioned configured diammonium hydrogen phosphate aqueous solution and ammonia water with a percentage concentration of 30% are added dropwise to the configured calcium nitrate aqueous solution at a rate of 5ml / min for reaction, and the pH value of the reaction solution is kept at 10. The temperature is 40°C. After the reaction is complete, it is left to stand for 5 minutes, and finally aged for 24 hours to prepare a suspension of hydroxyapatite as a raw material for spraying.

[0051] In this example, the B702 ele...

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Abstract

The invention relates to a biomedical material with a silver-ion-bearing hydroxyapatite coating, belonging to the field of the surface modification of biomedical materials. The biomedical material with the silver-ion-bearing hydroxyapatite coating solves the technical problems that the coating of the traditional bacteriostatic materials and solid powder raw materials is uneven because of density difference, the problem that the bacteriostatic materials are decomposed at high temperature because the plasma spraying temperature of the traditional powder is higher, as well as the defect that the structure of the of the traditional powder is compact, which is not beneficial for releasing bacteriostatic components. The invention provides the biomedical material for solving the technical problems. In the biomedical material, the silver-ion-bearing hydroxyapatite coating is prepared on at least one surface of a substrate material and is sprayed on the substrate material by liquid-phase plasma. The biomedical material effectively overcomes the defects of the traditional product, and the preparation method is simple and easy and has low cost.

Description

technical field [0001] The invention belongs to the field of surface modification of biomedical materials, and in particular relates to a biomedical material with silver ion-containing hydroxyapatite coating and a preparation method thereof. Background technique [0002] Biomedical materials are new high-tech materials used to repair or replace diseased tissues and organs of living organisms or enhance their functions. They generally refer to biomedical material implants that repair and replace teeth and bones. With the increase in the use of biomedical materials, the infection rate centered on biomedical materials has also increased significantly. Clinical applications have shown that inflammation around biomedical material implants has become an important reason for the decline in implant preservation rates. The hydroxyapatite coating provides a convenient place for bacteria to attach, and the trauma during the operation can easily cause microbial invasion and eventually l...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/32A61L27/10A61L27/04A61L27/06
Inventor 宋磊吴方甘露黄毅田志立肖严峰刘晓光吴尧
Owner SICHUAN UNIV
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