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Preparation technology for microspheric embolization agent

A preparation process and technology for embolic agents, which are applied in the field of preparation technology of microsphere-type embolic agents, can solve the problems of non-biocompatibility of the embolic agents, different particle sizes of the embolic agents, difficult identification and manipulation, and the like. Biocompatibility and stability, uniform and controllable particle size, and easy manipulation

Active Publication Date: 2012-05-23
SUZHOU HENGRUI CALLISYN BIOLOGICAL MEDICINE TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The preparation process is relatively simple, but the prepared embolic agent has different particle sizes and is difficult to separate. At the same time, the above-mentioned embolic agent is not biocompatible and has a hard texture, which is difficult to identify and manipulate in vivo and in vitro, and may cause incomplete embolism.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] Weigh the molecular weight 2×10 4 -5×10 4 Add 100g of polyvinyl alcohol into 500g of water, heat to 90°C, and stir at a speed of 190r / min for 2 hours. After the polyvinyl alcohol is fully dissolved, cool the solution to room temperature, then add 1.2g of sodium acrylate, and stir at a speed of 190r / min. Stir at a high speed for 6 hours to fully react the above-mentioned reactants. After the reaction is completed, the reaction product is vacuum-dried to obtain a gel-like functionalized macromolecular intermediate, which can be stored below room temperature.

[0036] Weigh 1.63g of 2-acrylamide-2-methylpropanesulfonic acid, 1.034g of potassium persulfate and 17.3g of water and stir and mix evenly. After the potassium persulfate is fully dissolved, add 40g of the above-mentioned functionalized macromolecular intermediate, and stir. To obtain a polymer monomer solution; take another 240mL of butyl acetate, add 4.55g of cellulose acetate, fully stir at a stirring speed of 2...

Embodiment 2

[0039] Weigh molecular weight 3×10 4 ~4×10 4 Add 200g of polyethylene glycol to 500g of water, heat to 80°C, and stir at a speed of 100r / min for 2.5h at the same time, after the polyethylene glycol is fully dissolved, cool the solution to room temperature, add 2.0g of butyl acrylate, Stir for 4 hours at a speed of 1 / min to fully react. After the reaction is completed, the reaction product is vacuum-dried to obtain a gel-like functionalized macromolecular intermediate, which can be stored below room temperature.

[0040] Weigh 1.73g of 2-acrylamide-2-methylpropanesulfonic acid, 1.044g of potassium persulfate and 18.8g of water and stir and mix evenly. After the potassium persulfate is fully dissolved, add 45g of the above-mentioned functionalized macromolecular intermediate, and stir. Obtain polymer monomer solution; take another 270mL of butyl acetate, add 4.60g of cellulose acetate, fully stir at a stirring speed of 300r / min for 10min, and then pass N 2 10min, heat at the s...

Embodiment 3

[0043] Weigh the molecular weight 4×10 4 ~5×10 4 Add 100g of amylose to 500g of water, heat to 90°C, and stir at a speed of 190r / min for 3 hours. After the amylose is fully dissolved, cool the solution to room temperature, add 1.2g of sodium acrylate, and stir at a speed of 190r / min. Stir for 6 hours to make it fully react. After the reaction is completed, the reaction product is vacuum-dried to obtain a gel-like functionalized macromolecular intermediate, which can be stored below room temperature;

[0044] Weigh 1.83g of 2-acrylamide-2-methylpropanesulfonic acid, 1.054g of potassium persulfate and 20.3g of water and stir and mix evenly. After the potassium persulfate is fully dissolved, add 40g of the above-mentioned functionalized macromolecular intermediate, stir and mix homogeneously, to obtain a polymer monomer solution; another 300mL of butyl acetate was added, 4.65g of cellulose acetate was added, fully stirred at a stirring speed of 360r / min for 10min, and then passe...

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Abstract

The invention relates to a preparation technology for a microspheric embolization agent. The preparation technology is used for preparing elastic microspheres cross-linked and polymerized by functionalized macromolecules with biocompatibility, wherein the grain range of the microspheres is 1-1500mu m. The preparation technology comprises the following steps that: a cross-linkable micromolecule with a crylic acid structure is connected on a polyvinyl alcohol, polyethylene glycol or polyose macromolecule in form of a covalent bond to form a functionalized macromolecule; and reversed phase suspension polymerization is conducted to the functionalized macromolecule and a 2-acrylamide-2-methylpropanesulfonic acid monomer to prepare cross-linked and polymerized microspheric embolization agent. The embolization agent has the advantages that the flexibility and the elasticity are high, the grain is even and is controllable, the dispersity is good, the raw materials are nontoxic and the biocompatibility and the stability are good. The preparation technology is a pure chemical synthesis technology, no virus pollution is caused to the raw materials and the preparation process, the requirements on international embolization agents are satisfied, and the embolization agent can substitute for all kinds of imported or domestic expensive embolization agent products and can be widely used in surgeries in the field of interventional therapy.

Description

technical field [0001] The invention relates to a preparation process of an embolic agent in the technical field of medical materials, in particular to a preparation process of a microsphere-type embolic agent used for interventional therapy to treat tumor diseases. Background technique [0002] With the maturity of interventional therapy, it is being more and more widely used in the field of medical technology. The principle of interventional therapy is to use a high-definition medical imaging device to guide a catheter into the tumor site in the human body through a small incision, and then infuse anti-tumor drugs through the blood supply artery or block the blood supply of the tumor tissue, so that the tumor can be cured in a short time. Necrosis, atrophy, to achieve the purpose of treatment. The key technology of interventional therapy is to choose the appropriate particle embolization agent for blocking the blood supply of tumor tissue. Mixed particles of paraffin and...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/16A61K47/32A61K47/36A61K47/38A61P35/00
Inventor 姚飞孙小薇
Owner SUZHOU HENGRUI CALLISYN BIOLOGICAL MEDICINE TECH CO LTD
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