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Process for extracting rutin from sophora japonica

A technology of Sophora japonica and process, which is applied in the preparation of sugar derivatives, sugar derivatives, sugar derivatives, etc., to achieve the effects of high extraction rate, low pressure, and reduction of extraction times and time.

Inactive Publication Date: 2010-09-01
桂林市振达生物制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But the purity of the product obtained by this method is only about 94%

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] 1) Take 1Kg of Huai Mi and grind it to 40 mesh, put it in an extraction tank, wash it with boiling water, and then pass it into the extraction solvent for reverse osmosis extraction for 3 hours, the extraction pressure is 0.27MPa; the amount of the extraction solvent is 20 times the weight of the raw material , the temperature is 35 DEG C, and the weight ratio of saturated lime water, borax and sodium sulfite in the solvent is 1000:5:1;

[0021] 2) The reverse osmosis extraction liquid is filtered through three stages (the first stage filter is 80 mesh, the second stage filter is 200 mesh, and the third stage filter is 300 mesh), after cooling to normal temperature, add hydrochloric acid to adjust the pH value to 3.5, crystallize, and The liquid was filtered with a plate and frame filter, washed with water until neutral, and dried at a temperature below 80°C to obtain 0.218Kg of yellow crystalline powder with a yield of 21.8%, and its purity was determined to be 99.6%. ...

Embodiment 2

[0023] 1) Take 1Kg of Sophora japonica and crush it to 20 mesh, put it in an extraction tank, wash it twice with boiling water, first add an appropriate amount of extraction solvent until the liquid level is 6 cm higher than the raw material, stir evenly, soak for 30 minutes, and then add the extraction solvent for reaction Percolation extraction for 4 hours, the extraction pressure is 0.2MPa; wherein the amount of extraction solvent is 15 times the weight of raw materials, the temperature is 45 ° C, and the weight ratio of saturated lime water, borax and sodium sulfite in the solvent is 1000:4:1.5;

[0024] 2) The reverse osmosis extract is filtered through three stages (100 mesh for the first stage filter, 150 mesh for the second stage filter, and 350 mesh for the third stage filter), after cooling to normal temperature, add hydrochloric acid to adjust the pH value to 4, crystallize, pump Filter, wash the crystals with water until neutral, and dry under the condition below 80...

Embodiment 3

[0026] 1) Take 1Kg of Sophora japonica and crush it to 60 mesh, put it in an extraction tank, wash it twice with boiling water, and then pass it into the extraction solvent for reverse osmosis extraction for 6 hours, and the extraction pressure is 0.3 MPa; 20 times, the temperature is 15°C, and the weight ratio of saturated lime water, borax and sodium sulfite in the solvent is 1000:6:0.5;

[0027] 2) The reverse osmosis extract is filtered through secondary filtration (150 mesh for primary filtration, 250 mesh for secondary filtration, after cooling to room temperature, add hydrochloric acid to adjust the pH value to 3, crystallize, take out the crystals, wash the crystals with water until neutral, Drying at a temperature below 80°C gave 0.208Kg of yellow crystalline powder with a yield of 20.8%, and its purity was determined to be 97.6%.

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PUM

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Abstract

The invention discloses a process for extracting rutin from sophora japonica, which comprises the following steps of: (1) preparing and crushing sophora japonica, putting the crashed sophora japonica into an extraction tank, washing and moistening the crashed sophora japonica with boiling water, and then, introducing an extraction solvent for carrying out reverse percolation extraction, wherein the extraction solvent is a mixture of saturated lime water, borax and sodium sulfite, the proportioning by weight of the saturated lime water to the borax to the sodium sulfite is 1000:4-6:0.5-1.5, and the pressure of the reverse percolation extraction is 0.2-0.3MPa; and (2) carrying out cascade filtration on the reverse percolation extraction solution, adding hydrochloric acid after cooling to regulate the pH value to 3-4, crystallizing, taking out crystals, washing the crystals with water to the neutrality, and drying the crystals to obtain finished products. Compared with the prior art, in the invention, by using reverse percolation extraction to replace percolation extraction and combining the extraction solvent with special proportioning, the rutin in the sophora japonica can be extracted more completely, thus the extraction rate is high, and residues in the percolation solution are few and can be filtered more easily; and the invention has the advantages of simple and convenient operation and short production cycle, and the product purity can reach more than 97.5%.

Description

technical field [0001] The invention relates to a process for extracting active components from plants, in particular to a process for extracting rutin from Sophora japonica. Background technique [0002] Sophora japonica L.r. is the dried flower and flower bud of the leguminous plant Sophora japonica L.r. Sophora japonica contains more than 20.0% rutin, which is the main raw material source of rutin. Rutin is a kind of flavonoid compound, its properties are yellow crystalline powder or amorphous powder, with bitter taste, slightly soluble in water, soluble in hot water and alcohol; easy to deteriorate when exposed to light, it should be stored in a cool place. Rutin is mainly used to treat capillary fragility and osmotic bleeding, lower blood lipids and cholesterol in the human body, and is a good medicine for treating hypertension, cardiovascular disease, stomach disease, skin disease, diabetes and other diseases. In addition, it has antibacterial and anti-radiation effe...

Claims

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Application Information

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IPC IPC(8): C07H17/07C07H1/08
Inventor 唐江明孙莉莉黄素春白玭
Owner 桂林市振达生物制药有限公司
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