Method for preparing self pore-forming calcium phosphate cement bracket

Abstract

The invention relates to a method for preparing a self pore-forming calcium phosphate cement bracket, which comprises the following steps of: 1) uniformly mixing calcium sulfate hemihydrate and tricalcium phosphate cement powder to obtain the mixed cement powder; 2) heating gelatin and NaH2PO4 with stirring in water at the temperature of between 45 and 50 DEG C until the gelatin and the NaH2PO4 are dissolved completely to obtain mixed solution; 3) uniformly mixing the mixed cement powder obtained by the step 1) and the solution obtained by the step 2), adding 25 to 50 percent aqueous solution of glutaraldehyde immediately, injecting the mixed cement powder slurry into a steel mould, then mixing the slurry at room temperature for 60 to 90 seconds, keeping the temperature of the slurry to be 37 DEG C after taking out, and then curing the slurry for 1 to 2 hours under the condition that the humidity is 100 percent to obtain the composite bracket. When the porosity is 71 percent, the average value of the compression strength can be increased to 8.1MPa; the bracket has high porosity and compression strength, and plays a better role in supporting in a human body, and the macropore diameter is between 100 and 300 mu m; and the self pore-forming calcium phosphate cement bracket prepared by the invention can be used as a repairing material of a human hard tissue.

Description

technical field [0001] The invention relates to a preparation method of a self-forming calcium phosphate bone cement bracket, which belongs to the technical field of preparation of biomedical materials. Background technique [0002] With the development of modern orthopedics, the degree of trauma and changes in orthopedic disease spectrum, as well as the improvement of people's requirements for postoperative functional recovery and quality of life. Clinically, bone defects caused by bone tumors, deformity and correction of limbs and spine, severe bone trauma, osteoporosis, osteonecrosis, etc., all need to be reconstructed and treated by bone grafting. However, due to the limited source of autologous bone, increased surgical trauma, and the risk of immune response and disease transmission in allogeneic bone, its clinical application is limited. Artificial bone implant materials have always been the focus of bone tissue research, hoping to replace autologous or allogeneic bon...

AI Technical Summary

Problems solved by technology

However, when calcium sulfate hemihydrate is used alone as a bone repair material, there are the following disadvantages: 1) the strength after curing is low, and it is difficult to provide the long-term mechanical strength required by the repair site; 2) it cannot form chemical bonds with the surrounding bone tissue at the initial stage of repair, Shows weak biological activity; 3) The degradation rate is too fast, and the time for calcium sulfate to be completely degraded and absorbed in the body varies depending on the implantation site, generally within 28 to 72 days

Due to the excessive concentration of local degradation products, which exceeds the decomposition and absorption of phagocytes and osteoclasts, and the degradation process is acidic, resulting in some incision complications, as a bone repair material, the physical and chemical properties of calcium sulfate hemihydrate still need to be improved

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