Scutellarein derivative as well as preparation method and application thereof

A technology of scutellarin aglycone and scutellarin aglycon, which is applied in the field of medicinal chemistry research, can solve the problems of low adverse reactions and high bioavailability, and achieve the effects of low adverse reactions, high bioavailability, and improved bioavailability
CN101891728AInactive Publication Date: 2010-11-24NANJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
NANJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE
Publication Date
2010-11-24
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention relates to the research field of medicinal chemistry, in particular to a novel scutellarein-6-site derivative (I), as well as a preparation method and an application thereof to medicines for preventing and treating thrombus. Pharmacological test results show that compared with scutellarin and scutellarein, the compound has better function of inhibiting platelet aggregation. The scutellarein-6-site derivative (I) provided by the invention can be used for treating a series of diseases caused by the thrombus, such as myocardial infarction, ischemia injury and so on.
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Description

technical field

[0001] The invention relates to the field of medicinal chemistry research, in particular to a novel scutellarin aglycon-6-position derivative (I), its preparation method and its application in antithrombotic drugs. Background technique

[0002] Scutellarin aglycon is a flavonoid compound in breviscapus breviscapus, a plant of the family Asteraceae. Erigeron breviscapus is cold in nature, slightly bitter, sweet and warm, and has the effects of dispelling cold and relieving the exterior, expelling wind and dampness, promoting blood circulation and removing blood stasis, dredging meridian and activating collaterals, reducing inflammation and relieving pain. Breviscapine is a flavonoid active ingredient extracted from the natural plant breviscapine, including a mixture of scutellarin and scutellarin, mainly scutellarin (the content is more than 95%) (Chen Yiyue, Wang Shengtao, Zeng Wenshan, Zhu Yinghong, Fu Yongmei, Jiang Tao. Relaxation effect of breviscapine o...

Claims

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